What are Neurotransmitter Release Sites and Do They Interact?

Ge, Daochuan; Noakes, Peter G.; Lavidis, Nickolas A.

doi:10.1016/j.neuroscience.2019.11.017

Cited by 5 publications

(2 citation statements)

References 186 publications

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“…In the nervous system, changes in synaptic potentials and nerve impulses of neurons are the basic conditions for nerve function [8]. Complexin is an important neurotransmitter release regulator protein in the presynaptic structure [9,10].…”

Section: Introductionmentioning

confidence: 99%

Expression of CPLX1 in Different Degrees of Spinal Cord Injury in Subacute Stage

Xi¹,

Ji²,

Bao³

et al. 2020

IJN

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This study is to explore the expression of CPLX1 (Complexin 1) in spinal cord tissues with different degrees of injury in the subacute phase of spinal cord injury. Twenty-four SD rats were randomly divided into three experimental groups (light, medium and severe injury) and a sham-operated control group. The experimental group made acute spinal cord injury models according to the lisa method, and the spinal cord tissue were collected 72 hours after injury. The tissues of rats were taken for transcriptome high-throughput sequencing and proteomic analysis experiments to observe the expression of CPLX1 in the different degrees during the subacute phase of spinal cord injury. The mRNA and protein of CPLX1 were detect in rat spinal cord tissue, and they were expressed high in the sham operation group. The protein expression in the light injury group began to decrease, and with the increase of the degree of injury, the transcription level of CPLX1 and the amount of protein expression also gradually decreased. The change trend of mRNA transcription level and protein expression level was basically the same. When the spinal cord injury heavier, the less CPLX1 was expressed, the two showed a significant negative correlation. In the subacute stage of spinal cord injury, the translation and protein levels of CPLX1 decreased significantly. The more severe the injury, the lower the transcription level and protein expression level. CPLX1 may be used as a marker gene for the severity of spinal injury.

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Section: Introductionmentioning

confidence: 99%

Expression of CPLX1 in Different Degrees of Spinal Cord Injury in Subacute Stage

Xi¹,

Ji²,

Bao³

et al. 2020

IJN

View full text Add to dashboard Cite

show abstract

“…Much later, in 1973, Timothy Vivian Pelham Bliss and Terje Lømo discovered a similar phenomenon in the central nervous system (Bliss & Lømo, 1973 ). Even as late as 2020, Feng’s article published in Chinese Physiology Journal ( English edition ) in 1940 was still cited in a paper related to synaptic plasticity research (Ge, Noakes, & Lavidis, 2020 ). These two examples demonstrate the great enduring significance of Feng’s pioneering work in the field of synaptic plasticity.…”

mentioning

confidence: 99%