What are the Benefits of Exercise for Alzheimer’s Disease? A Systematic Review of the Past 10 Years

Hernández, Salma Stéphany Soleman; Sandreschi, Paula Fabrício; Silva, Franciele C. da; Arancibia, Beatriz Angélica Valdivia; Silva, Rudney da; Gutierres, Paulo J.B.; Andrade, Alexandro

doi:10.1123/japa.2014-0180

Cited by 83 publications

(74 citation statements)

References 11 publications

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“…Dal Bello-Haas et al 2014;Bowes et al 2013;Lamotte et al 2017;Hernández et al 2015;Wei-Wei et al 2016;Duggan et al, 2008;Pitkälä et al 2010;World Health Organization, 2010 Mental wellbeing Cognitive stimulation with the aim to improve or sustain ability to communicate and interact with each other. Woods et al 2012;van Nes, 2013;Genoe & Dupuis, 2014;Hill et al 2017;Mondini et al 2016;Spector et al, 2017 Individual activities Individual activities as a source to gain strength and to nurture social relationships.…”

Section: Methodsmentioning

confidence: 99%

Living Life and Doing Things Together: Collaborative Research With Couples Where One Partner Has a Diagnosis of Dementia

et al. 2018

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The aim of this study is to identify relevant content for a self-management guide by using the outcomes of previous research in combination with knowledge and experiences from couples where one partner has a diagnosis of dementia. The study was carried out in three phases: 1) Literature search of previous research related to wellbeing and couplehood in dementia; 2) Interviews with couples with dementia based on the findings of the literature search; 3) Further authentication of the findings within expert groups of people with dementia and carers. For analysis of data we used a hybrid approach of thematic analysis with combined deductive and inductive approaches. The findings of this study indicated that the four main themes "Home and Neighborhood", "Meaningful activities and Relationships", "Approach and Empowerment" and "Couplehood" with related sub themes could be appropriate targets for a self-management guide for couples where one partner has a diagnosis of dementia.

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Section: Methodsmentioning

confidence: 99%

Living Life and Doing Things Together: Collaborative Research With Couples Where One Partner Has a Diagnosis of Dementia

et al. 2018

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“…Although advancing age is clearly considered the main risk factor for developing AD [21–23], nutritional factors [24], low levels of physical activity [25, 26], reduced cognitive stimulation [27], socioeconomic status and educational attainment [28–30] are all directly related to AD risk. Furthermore, poor sleep quality [31–33] which is known to positively correlate to early Aβ deposition [34, 35], air pollution [36], smoking [37], intake of metals [38–40], pesticides and insecticides [41, 42] as well as metabolic-related dysfunctions [43, 44] have all been described as possible risk factors.…”

Section: The Ad Research Paradigm Is Failing: Main Facts Supporting Tmentioning

confidence: 99%

“…These trials have proven to be the most effective strategies to reduce AD symptoms [20, 25, 26, 54–59]. …”

Section: Addressing Human Relevance In Ad Research With the Use Of Almentioning

confidence: 99%

Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities

et al. 2016

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Much of Alzheimer disease (AD) research has been traditionally based on the use of animals, which have been extensively applied in an effort to both improve our understanding of the pathophysiological mechanisms of the disease and to test novel therapeutic approaches. However, decades of such research have not effectively translated into substantial therapeutic success for human patients. Here we critically discuss these issues in order to determine how existing human-based methods can be applied to study AD pathology and develop novel therapeutics. These methods, which include patient-derived cells, computational analysis and models, together with large-scale epidemiological studies represent novel and exciting tools to enhance and forward AD research. In particular, these methods are helping advance AD research by contributing multifactorial and multidimensional perspectives, especially considering the crucial role played by lifestyle risk factors in the determination of AD risk. In addition to research techniques, we also consider related pitfalls and flaws in the current research funding system. Conversely, we identify encouraging new trends in research and government policy. In light of these new research directions, we provide recommendations regarding prioritization of research funding. The goal of this document is to stimulate scientific and public discussion on the need to explore new avenues in AD research, considering outcome and ethics as core principles to reliably judge traditional research efforts and eventually undertake new research strategies.

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“…Redefining the strategy by which current and future NIH research budget is allocated is of particular relevance, especially considering the major role played by lifestyle factors, such as nutrition, physical activity, and level of cognitive training in the determination of AD risk [27][28][29][30][35][36][37] as well as the proven efficacy of intervention strategies aimed at preventing dementiarelated symptoms [88][89][90].…”

Section: Discussionmentioning

confidence: 99%

“…The primary risk factors for AD include advancing age [27][28][29], nutritional patterns characterized by low intake of plant-derived foods [30], together with metabolic syndrome-related dysfunctions (e.g., cardiovascular disease and diabetes) [8,31], low socioeconomic status and a low level of educational attainment [32][33][34], low level of daily physical activity [35,36], and low cognitive training [37]. Additionally, sleep disorders [38][39][40], known to positively correlate to early A␤ deposition [41,42], exposure to air pollution [43], smoking [44], and the intake of metals (e.g.…”

Section: The Population and Individual Levels: Epidemiological Studiementioning

confidence: 99%

A Human-Based Integrated Framework forAlzheimer’s Disease Research

Pistollato

Cavanaugh

Chandrasekera

2015

JAD

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Abstract. Animal models of Alzheimer's disease (AD) have been extensively utilized for decades in an effort to elucidate the pathophysiological mechanisms of this disease and to test novel therapeutic approaches. However, research success has not effectively translated into therapeutic success for human patients. This translational failure is partially due to the overuse of animal models that cannot accurately recapitulate human AD etiopathogenesis or drug responses and the inadequate use of human-relevant research methods. Here, we propose how to mitigate this translational barrier by employing human-based methods to elucidate disease processes occurring at multiple levels of complexity, accounting for gene and protein expression and the impact of disease at the cellular, tissue/organ, individual, and population levels. In particular, novel human-based cellular and computational models, together with epidemiological and clinical studies, represent the ideal tools to facilitate human-relevant data acquisition, in the effort to better elucidate AD pathogenesis in a human-based setting and design more effective treatments and preventive strategies. Our analysis indicates that a paradigm shift toward human-based, rather than animal-based research is required in the face of the ever-increasing prevalence of AD in the 21st century.

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What are the Benefits of Exercise for Alzheimer’s Disease? A Systematic Review of the Past 10 Years

Cited by 83 publications

References 11 publications

Living Life and Doing Things Together: Collaborative Research With Couples Where One Partner Has a Diagnosis of Dementia

Living Life and Doing Things Together: Collaborative Research With Couples Where One Partner Has a Diagnosis of Dementia

Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities

A Human-Based Integrated Framework forAlzheimer’s Disease Research

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