What are the Endoscopic and Pathological Characteristics of Colorectal Polyps?

Abstract

Background: Colon polyps need to be excised upon detection during colonoscopy due to the risk of malignancy irrespective of their size. In our study, we retrospectively evaluated the clinicopathological characteristics of polyps detected during colonoscopy. Materials and Methods: We assessed 379 patients with polyps detected during colonoscopy between January 2010 and May 2012. The demographics, complaints, colonoscopy findings (shape, place and size of the polyp) and histopathological findings were recorded. We carried out statistical analysis using PASW 18.0 for Windows. Results: There were 227 males (59.9%) and 152 females (40.1%) in the trial. The mean age was 53.8 years (32-90). The most common complaint was rectal bleeding (36.1%), followed by abdominal pain (35.4%). Polyps were detected most commonly in the rectosigmoid region (43.8%), followed by the descending colon (17.4%). Some 239 patients had a single polyp (63.1%) while 140 were found to have multiple polyps (36.9%). While tubular adenoma was the most common pathological type, occurring in 181 patients (47.8%), tubulovillous adenoma (14.2%) and hyperplastic polyp (12.7%) followed, occurring in 54 and 48 patients respectively. While 313 patients (82.6%) did not feature dysplasia, 37 patients (9.7%) exhibited lowgrade dysplasia, 28 (7.7%) had high-grade dysplasia and 4 had cancer (1.1%). The rates of villous components and dysplasia were detected to be high among pedunculated polyps and polyps larger than 1 cm (p<0.001). Conclusions: Due to the fact that large-diameter polyps with malignant potential are commonly located in the left colon and have a high prevalence among the middle-aged individuals, it would be appropriate to screen this population at regular intervals via rectosigmoidoscopy.

Risk Factors for High-Risk Adenoma on the First Lifetime Colonoscopy Using Decision Tree Method: A Cross-Sectional Study in 6,047 Asymptomatic Koreans

“…The 0-Isp or 0-Ip type polyps were more likely to be adenomatous or AN than 0-Is polyps or flat lesions. It seems that pedunculated polyps are more likely to be adenomas or ANs than sessile polyps which is consistent with a previous study ( 33 ).…”

“…In the model of the study, size is an important step in determining histologic grade in rectosigmoid polyps. Most previous studies have shown a marked increase in histologic grade at 1 cm cut off ( 33 , 34 , 36 ) which is one of the criteria for AN ( 37 , 38 ). However, the model shows a cutoff of 5 mm was significant for differentiating each node.…”

“…It is already known that a larger polyp size is related to AN (29,(31)(32)(33)(34)(35)(36). In the model of the study, size is an important step in determining histologic grade in rectosigmoid polyps.…”

Effects of Jianpi Lishi Jiedu Granules on Colorectal Adenoma Patients after Endoscopic Treatment: Study Protocol for a Randomized Controlled Trial

“…[5,6]. Currently, the conventional treatment methods for CRA include high-frequency electrocoagulation and electroexcision, biopsy forceps polypectomy, cauterization by laser and microwave and other ensdoscopic interventions [7]. Although these interventions generally entail less trauma incurred by the patients, quick postoperative recovery, and simplicity of operation, surgeons also face some clinical di culties related to these interventions; for example, the symptoms experienced by patients cannot be completely improved after endoscopic resection, and microscopic resection cannot reduce the recurrence rate.…”

MicroRNAs as non-invasive screening biomarkers of colorectal cancer

“…Giraldez et al [ 20 ] also found out a panel of 6 miRNAs (miRNA-18a, miRNA-19a, miRNA-19b, miRNA-15b, miRNA-29a and miRNA-335) to be up-regulated in CRC patients, and discovered miRNA-18a to be notably up-regulated in patients with advanced adenomas. Although adenomas are benign tumors, part of them may transform into malignant tumors [ 21 , 22 ]. Some miRNAs involved in tumorigenesis present aberrant expression even since the adenoma stage.…”