What are the Main Risk Factors Associated with Erectile Dysfunction in the Elderly? A Cross-Sectional Study of 2436 Brazilian Elderly Men

Pitta, Rafael Mathias; Queiroga, Luana de Lima; Louzada, Andressa Cristina Sposato; Ritti‐Dias, Raphael Mendes; Kaufmann, Oskar Grau; Wolosker, Nelson

doi:10.2147/cia.s405121

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…In terms of age, erectile function declines with men's age, a finding confirmed in recent studies ( 21 , 22 ), and the mechanism may be related to the decline in testosterone levels and the large deposition of collagen fibers in the penile corpus cavernosum ( 23 ); with age, vascular endothelial growth factor (VEGF) becomes markedly under-signaled, leading to a decline in vascular endothelial function, an obvious trigger for coronary heart disease ( 24 , 25 ). VEGF plays a role in the development of vasogenic erectile dysfunction, and patients with the presence of VEGF disorders have a significant decrease in erectile function compared to the normal population ( 26 , 27 ).…”

Section: Discussionsupporting

confidence: 79%

Does erectile dysfunction predict cardiovascular risk? A cross-sectional study of clinical characteristics in patients with erectile dysfunction combined with coronary heart disease

Li,

Zhang,

et al. 2024

Front. Cardiovasc. Med.

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BackgroundErectile Dysfunction (ED) is a common sexual dysfunction in men who are unable to consistently obtain and maintain sufficient penile erection to accomplish a satisfactory sexual life. ED is currently considered to be a predictor of cardiovascular disease (CVD), but few studies have observed the association between ED and clinical features of coronary heart disease (CHD). An investigation of the association between ED and clinical characteristics of CHD was carried out using a cross-sectional study design.MethodsThis cross-sectional single-center study was conducted in the Department of Cardiology and included 248 patients. Associations between patients' general information, underlying disease information, coronary heart disease information, and ED severity were statistically and analytically analyzed using SPSS 26.0 software. Patients with comparable clinical characteristics were grouped together using K-means clustering. Finally, ordered logistic regression analysis was performed for general and underlying disease information.ResultsIn the comparison of general data, age, education, and weekly exercise were associated with the distribution of ED severity. In the comparison of underlying disease information, the number of underlying diseases, hypertension, diabetes, hyperlipidemia, anxiety state, and depressive state were associated with the distribution of ED severity. In the comparison of CHD information, the degree of ED severity was associated with CHD subtypes, lesion sites, number of stenoses, degree of stenosis, and interventional interventions. The time from ED to CHD onset was associated with the subtypes of CHD and the number of stenoses. We clustered the main characteristics of low-risk and high-risk patients and ordered logistic regression analysis found that BMI, smoking, alcoholism, number of underlying diseases, diabetes, anxiety state, and depression state were all risk factors for CHD severity (P < 0.05); the higher the value of the above factors, the more severe the degree of CHD. Age was a protective factor for CHD severity; the younger the patient, the lower the likelihood of myocardial infarction.ConclusionED severity and the time from ED to CHD onset may be predictive of coronary heart disease severity. Reducing smoking and alcohol consumption, maintaining a healthy body weight, and regular physical activity are important in preventing CVD in ED patients.

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Section: Discussionsupporting

confidence: 79%

Does erectile dysfunction predict cardiovascular risk? A cross-sectional study of clinical characteristics in patients with erectile dysfunction combined with coronary heart disease

Li,

Zhang,

et al. 2024

Front. Cardiovasc. Med.

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Risk factors for erectile dysfunction in diabetes mellitus: a systematic review and meta-analysis

Dilixiati,

Waili,

Tuerxunmaimaiti

et al. 2024

Front. Endocrinol.

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BackgroundPrevious studies have established that diabetes mellitus (DM) markedly raises the risk of developing erectile dysfunction (ED). Despite extensive investigations, the risk factors associated with ED in diabetic men have yet to be unequivocally determined, owing to incongruent and inconclusive results reported in various studies.ObjectiveThe objective of this systematic review and meta-analysis was to assess the risk factors for ED in men with DM.MethodsA comprehensive systematic review was conducted, encompassing studies published in the PubMed, Scopus and Embase databases up to August 24th, 2023. All studies examining the risk factors of ED in patients with DM were included in the analysis. To identify significant variations among the risk factors, odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were employed. The risk of bias was evaluated using the Newcastle-Ottawa Scale(NOS) for longitudinal studies and the Agency for Healthcare Research and Quality Scale(AHRQ) for cross-sectional studies.ResultsA total of 58 studies, including a substantial participant pool of 66,925 individuals diagnosed with DM, both with or without ED, were included in the meta-analysis. Mean age (OR: 1.31, 95% CI=1.24-1.37), smoking status (OR: 1.32, 95% CI=1.18-1.47), HbA1C (OR: 1.44, 95% CI=1.28-1.62), duration of DM (OR: 1.39, 95% CI=1.29-1.50), diabetic neuropathy (OR: 3.47, 95% CI=2.16-5.56), diabetic retinopathy (OR: 3.01, 95% CI=2.02-4.48), diabetic foot (OR: 3.96, 95% CI=2.87-5.47), cardiovascular disease (OR: 1.92, 95% CI=1.71-2.16), hypertension (OR: 1.74, 95% CI=1.52-2.00), microvascular disease (OR: 2.14, 95% CI=1.61-2.85), vascular disease (OR: 2.75, 95% CI=2.35-3.21), nephropathy (OR: 2.67, 95% CI=2.06-3.46), depression (OR: 1.82, 95% CI=1.04-3.20), metabolic syndrome (OR: 2.22, 95% CI=1.98-2.49), and diuretic treatment (OR: 2.42, 95% CI=1.38-4.22) were associated with increased risk factors of ED in men with DM.ConclusionOur study indicates that in men with DM, several risk factors for ED have been identified, including mean age, HbA1C, duration of DM, diabetic neuropathy, diabetic retinopathy, diabetic foot, cardiovascular disease, hypertension, microvascular disease, vascular disease, nephropathy, depression, metabolic syndrome, and diuretic treatment. By clarifying the connection between these risk factors and ED, clinicians and scientific experts can intervene and address these risk factors, ultimately reducing the occurrence of ED and improving patient management.

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Sexual dysfunction, depression, and marital adjustment in diabetic male patients

Rathod,

Sawant,

Bandgar

2024

Indian Journal of Psychiatry

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Background: Type 2 diabetes affects 10.5% of adults globally, with sexual dysfunction being one of the complications, of which erectile dysfunction is the most commonly reported one with the prevalence ranging from 35% to 90%. There are a few studies exploring links between sexual dysfunction, depressive symptoms, and marital satisfaction, which is the reason we undertook the study. Aim: To study the prevalence of sexual dysfunction, depressive symptoms, and marital satisfaction in male patients with diabetes and correlation between the three parameters. Methods: A total of 120 male patients with type 2 diabetes were assessed for sexual dysfunction using ICD-10 criteria and International Index of Erectile Function, depressive symptoms using Beck Depression Inventory, and marital satisfaction using Dyadic Adjustment Scale (DAS). Results: The mean age of patients at diagnosis of diabetes was 42.32 ± 7.48 years, and the mean duration of diabetes was 7.35 ± 3.76 years. Mean HbA1c was 9.05 ± 2.25% with only 22 patients having good glycemic control. Eight-eight patients reported sexual dysfunction with lack of genital response, premature ejaculation, and orgasmic dysfunction being common. Thirty-two patients had depressive symptoms, with borderline clinical depressive symptoms and moderate depressive symptoms in 14 patients each. Marital satisfaction was affected with the total mean DAS score being 93.95 ± 18.34. There was a negative correlation seen between sexual function and depressive symptoms and also between sexual function and increasing age, with a positive correlation seen between sexual function and marital satisfaction. Poor glycemic control was significantly associated with clinically diagnosed erectile and orgasmic dysfunction. Conclusions: Sexual dysfunctions, depressive symptoms, and marital distress are highly prevalent in patients with type 2 diabetes, warranting timely detection and management. The three parameters are significantly correlated with each other, and poor glycemic control is significantly associated with sexual dysfunction. Psychiatric liaison would improve outcomes.

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What are the Main Risk Factors Associated with Erectile Dysfunction in the Elderly? A Cross-Sectional Study of 2436 Brazilian Elderly Men

Cited by 3 publications

References 35 publications

Does erectile dysfunction predict cardiovascular risk? A cross-sectional study of clinical characteristics in patients with erectile dysfunction combined with coronary heart disease

Does erectile dysfunction predict cardiovascular risk? A cross-sectional study of clinical characteristics in patients with erectile dysfunction combined with coronary heart disease

Risk factors for erectile dysfunction in diabetes mellitus: a systematic review and meta-analysis

Sexual dysfunction, depression, and marital adjustment in diabetic male patients

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