What can food-image tasks teach us about anorexia nervosa? A systematic review

Lloyd, Eva; Steinglass, Joanna E.

doi:10.1186/s40337-018-0217-z

Cited by 48 publications

(44 citation statements)

References 100 publications

(181 reference statements)

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“…Holsen 5 also noted that earlier studies show less consistent results, possibly due to methodological differences. Our study only assessed neural response to taste, but other studies suggest altered mid-insula and striatal responses to other interoceptive stimuli 30,31 , reward prediction error 25,34 , and food images 35 . We previously showed reduced ventral striatal response to monetary rewards when hungry 16 , suggesting that a dysfunction of homeostatic influences on neural processing of salient stimuli or reward is not restricted to food in AN but may generalize to secondary reinforcers (e.g., money) as well.…”

Section: Discussionmentioning

confidence: 99%

Neural Insensitivity to the Effects of Hunger in Women Remitted From Anorexia Nervosa

Kaye

Wierenga

Bischoff‐Grethe

et al. 2020

AJP

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Objective: Anorexia nervosa (AN) has the highest mortality rate of any psychiatric condition, yet the pathophysiology of this disorder and its primary symptom-extreme dietary restrictionremains poorly understood. In states of hunger relative to satiety, the rewarding value of food stimuli normally increases to promote eating, yet individuals with AN avoid food despite emaciation. This study aimed to examine potential neural insensitivity to these effects of hunger in AN. Method: At two counterbalanced visits, one after a 16-hour fast and one after a standardized meal, 26 women remitted from AN (RAN; to avoid the confounding effects of malnutrition) and 22 matched control women (CW) received tastes of sucrose and water while functional MRI data were acquired. Within a network-of-interest responsible for food valuation and transforming taste signals into motivation to eat, we compared groups across conditions on blood-oxygen-leveldependent (BOLD) signal and task-based functional connectivity. Results: Subjects had similar BOLD responses to sucrose and water tastants. A Group x Condition interaction in the ventral caudal putamen indicated that hunger had opposite effects on tastant response in CW and RAN participants: CW showed an increase, and RAN showed a decrease, in BOLD response when hungry. Hunger had a similar opposite effect on insula-toventral caudal putamen functional connectivity in RAN compared with CW. Exploratory analyses indicated that lower caudate response to tastants when hungry was associated with higher harm avoidance among RAN participants.

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Section: Discussionmentioning

confidence: 99%

Neural Insensitivity to the Effects of Hunger in Women Remitted From Anorexia Nervosa

Kaye

Wierenga

Bischoff‐Grethe

et al. 2020

AJP

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“…Systematic reviews suggest that individuals with anorexia nervosa (AN) or bulimia nervosa (BN), compared to healthy controls (HCs), rate food pictures as less pleasurable (Giel et al, 2011; Lloyd & Steinglass, 2018). However, there is also evidence that individuals with binge‐eating disorder (BED) and BN rate high‐calorie food images as more pleasurable (Leehr et al, 2016), have greater reward responsivity to these stimuli in neuroimaging protocols (Schienle, Schaefer, Hermann, & Vaitl, 2009), and report greater urges to binge after food exposure (Meule et al, 2018; Staiger, Dawe, & McCarthy, 2000), and behavioural tasks (Svaldi et al, 2014).…”

Section: Introduction and Aimsmentioning

confidence: 99%

Multi‐method assessment of palatable food exposure in women with and without eating disorders

Christensen

French

Chen

2020

Euro Eating Disorders Rev

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Objective Eating disorders (EDs) are characterized by dysregulated responses to palatable food. Using a multi‐method approach, this study examined responses to palatable food exposure and subsequent ad libitum eating in women with binge‐eating disorder (BED: n = 64), anorexia nervosa (AN: n = 16), and bulimia nervosa (BN: n = 35) and 26 healthy controls (HCs). Method Participants were exposed to palatable food followed by an ad libitum eating opportunity. Affective and psychophysiological responses were measured before and during the task. Results Participants with EDs reported greater negative affect, particularly fear, following the food cue exposure, whereas HCs reported no change. BN and BED groups reported greater urge to binge after the food cue exposure, whereas AN and HC groups reported no change. Respiratory sinus arrhythmia levels, skin conductance and tonic skin conductance levels increased during food exposure for all groups. Across baseline and during the food exposure, the BED group had lower respiratory sinus arrhythmia levels relative to the BN and HC groups. The BED group consumed significantly more palatable food than the AN group. Conclusions ‘Palatable’ food stimuli elicited more negative affect, particularly fear, in individuals with EDs; and this, rather than psychophysiological responses, distinguishes individuals with EDs from those without.

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“…The majority of neuroimaging studies in the field of ED have investigated the neurobiological correlates of body shape, reward and food stimuli [15,16], while the number of studies focusing on emotion/empathy is still scarce and almost limited to the functional magnetic imaging (fMRI) correlates of implicit and/or explicit face emotion processing in patients affected by AN [17–22]. In BN much less is known regarding the neural circuits underlying emotion processing [16] and hardly any neuroimaging study adopted a transdiagnostic approach by including both AN and BN.…”

Section: Introductionmentioning

confidence: 99%

Emotional responsiveness task in emotional distress: correlated of functional neuroimaging in anorexia and bulimia

D’Agata

Caroppo

Spalatro

et al. 2020

Preprint

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30Aim: The present study aims to extend the knowledge of the neural correlates of emotion 31 processing in first episode subjects affected by anorexia nervosa (AN) or bulimia nervosa 32 (BN). We applied an emotional distress paradigm targeting negative emotions thought to 33 be relevant for interpersonal difficulties and therapeutic resistance mechanisms. 34 Methods: The current study applied a neuroimaging paradigm eliciting affective responses 35 to 44 female participants with newly diagnosed AN or BN and 20 matched controls. The 36 measurements also included an extensive assessment comprised of clinical scales, 37 neuropsychological tests, measures of emotion processing and empathy. 38 Results: AN and BN did not differ from controls in terms of emotional response, emotion 39 matching, self-reported empathy and cognitive performance. However, scores of eating 40 disorder and psychopathological clinical scores, as well alexithymia levels, were increased 41 in AN and BN. On a neural level, no significant group differences emerged, even when 42 focusing on a region of interest selected a priori: the amygdala.43 Conclusions: Our data are against the hypothesis that participants with AN or BN display a 44 reduced emotional responsiveness. This supports the hypothesis that relational difficulties, 45 as well as therapeutic resistance, are not secondary to simple difficulty in feeling and 46 identifying basic negative emotions in AN and BN participants. Negative emotions fMRI in AN and BN 65 diagnostic criteria of ED (DSM-5 and ICD-10), emerging evidence points to deficits in 66 socioemotional functioning [9]. Consequently, several modern therapeutic models 67 incorporate the role of emotional difficulties, social anxiety and poor social support in the 68 maintenance of the disorder [8].69Empathy represents a core function for social coherence and building relationships [10]. 70Based on the abovementioned socio-emotional difficulties and related problems in ED, one 71 may assume that empathy is systematically altered in ED and its impairment potentially 72 represents a relevant risk factor. Several studies applied self-reported empathy measures Negative emotions fMRI in AN and BN 4 73 or assessed emotion recognition performance but reported mixed results [11][12][13][14]. Thus, it 74 is unclear how much emotion processing, empathy and social competencies are affected 75 in ED and what mechanisms mediate the insurgence of relational difficulties. 76The majority of neuroimaging studies in the field of ED have investigated the 77 neurobiological correlates of body shape, reward and food stimuli [15,16], while the 78 number of studies focusing on emotion/empathy is still scarce and almost limited to the 79 functional magnetic imaging (fMRI) correlates of implicit and/or explicit face emotion 80 processing in patients affected by [17][18][19][20][21][22]. In BN much less is known regarding the 81 neural circuits underlying emotion processing [16] and hardly any neuroimaging study 82 adopted a transdiagnostic approach b...

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What can food-image tasks teach us about anorexia nervosa? A systematic review

Cited by 48 publications

References 100 publications

Neural Insensitivity to the Effects of Hunger in Women Remitted From Anorexia Nervosa

Neural Insensitivity to the Effects of Hunger in Women Remitted From Anorexia Nervosa

Multi‐method assessment of palatable food exposure in women with and without eating disorders

Emotional responsiveness task in emotional distress: correlated of functional neuroimaging in anorexia and bulimia

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