The article is devoted to modern directions for improving of the medical care for women with artificial interruption of pregnancy, in particular, the use of non-surgical methods of abortion. One of the most important tasks of an obstetrician-gynecologist is to reduce possible early and late postoperative complications during surgical abortion, and to preserve the reproductive function of a woman. The term “medical abortion” refers to the interruption of a pregnancy with medication, which is an alternative to surgery because it avoids the risks which are associated with surgery and anesthesia. The idea of using drugs to terminate pregnancy has existed for many centuries, but real and safe recommendations for the use of regimens, methods and conditions are constantly being improved and are now based on scientific evidence.A large number of studies all over the world indicate a significant need for the use of misoprostol and mifepristone in obstetrics and gynecology, as well as the search for optimal doses of these drugs to reduce the incidence of side effects and determine long-term effects in medical abortion. The article describes the most effective regimen, which involves the use of drugs mifepristone and misoprostol for abortion. The indications, contraindications and conditions necessary for the successful and safe performance of non-surgical abortion are presented. The mechanisms of action of drugs, their effectiveness, as well as possible side effects and complications are presented. The advantages of medical abortion, including high efficiency, low risk of complications, no risk associated with anesthesia, the possibility of avoiding surgery, the possibility of outpatient use, are demonstrated.