What causes cryptogenic fibrosing alveolitis? A case-control study of environmental exposure to dust.

Scott, John; Johnston, I. D. A.; Britton, John

doi:10.1136/bmj.301.6759.1015

Cited by 211 publications

(157 citation statements)

References 11 publications

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“…In a small case control study, patients with cryptogenic fibrosing alveolitis were determined to be more likely to live in a house heated by a wood fire (33). Several studies have described lung fibrosis which resembles pneumoconiosis including cases with progressive massive fibrosis among subjects exposed to wood smoke.…”

Section: Iap Has Been Considered a Risk Factor For Copd By The Globalmentioning

confidence: 99%

Biomass smoke exposure as a serious health hazard for women

Babalik

Bakırcı²,

Taylan³

et al. 2013

Tuberk Toraks

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Section: Iap Has Been Considered a Risk Factor For Copd By The Globalmentioning

confidence: 99%

Biomass smoke exposure as a serious health hazard for women

Babalik

Bakırcı²,

Taylan³

et al. 2013

Tuberk Toraks

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“…There are many ILDs with different etiologies and histological manifestations, and histological manifestation does not correspond to etiology according to a one-to-one relation (Scott et al 1990;Baumgartner 2000;Miyake 2005). In addition, HP cases indistinguishable from IIPs have recently been recognized (Chiba et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Increased Prevalence of High Anti-<i>Cladosporium</i> Antibody Titers in Interstitial Lung Diseases

Watanuki

Okada

Chiba

et al. 2012

Tohoku J. Exp. Med.

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Interstitial lung diseases (ILDs) represent a large group of different diseases, with a large part comprising idiopathic interstitial pneumonias. Differentiating hypersensitivity pneumonitis (HP), especially its chronic form and other ILDs, is difficult because of similarities in radiological manifestation and clinical course, and the difficulty of identifying causative antigens. We recently experienced a patient with Cladosporiuminduced chronic HP that developed in a household environment, but the cause had been misdiagnosed as idiopathic interstitial pneumonia for several years. This case highlighted the need for measures differentiating HP from idiopathic interstitial pneumonia. In this study, we examined fungal exposure in ILDs using an antibody titer in serum to identify possible fungus-related HP. We measured the antibody titer to Cladosporium spp. in 34 patients with various ILDs, 17 patients with bronchial asthma, and 21 control subjects using an immunofluorescence assay. ILDs included HP (5 patients), idiopathic interstitial pneumonias (21 patients), and ILDs with collagen vascular diseases (8 patients). Results showed a significantly higher tendency for high anti-Cladosporium antibody titers in ILD groups (12 patients out of 34 patients), compared to patients with bronchial asthma (0/17) or control subjects (0/21). This increase in antibody titers was observed not only in patients with HP, but also in those with idiopathic interstitial pneumonias and those exhibiting collagen vascular diseases with ILDs. This report highlights the pathogenic role of fungal antigens in various ILDs. In conclusion, fungi commonly observed in our living environment such as Cladosporium could be involved in the development of ILDs.

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“…Schematic of particle-and fiber-associated interstitial fibrosis. While pneumoconiosis and hypersensitivity pneumonitides are widely recognized to follow dust exposures, some relationship also exists between particles and fibers and idiopathic pulmonary fibrosis, diffuse interstitial pneumonitis, sacrcoidosis, eosinophilic granuloma, and pulmonary alveolar proteinosis regions of England were examined [8]. Patients with IPF were documented to have basal crackles, restrictive pulmonary function, and an absence of exposure to known fibrogenic agents in the past.…”

Section: Idiopathic Pulmonary Fibrosismentioning

confidence: 99%

“…According to the current definition, IPF is a distinctive type of chronic fibrosing interstitial pneumonia of unknown cause limited to the lungs and associated with a surgical lung biopsy showing a histologic pattern of usual interstitial pneumonia (UIP) [7]. A diagnosis of idiopathic pulmonary fibrosis is made in an estimated 5 out of every 100.000 patients [8]. A more recent population-based study for all interstitial lung diseases in the county population of Bernalillo, New Mexico revealed a prevalence of 20.2 cases per 100.000 for males and 13.2 cases per 100.000 for females with IPF [3].…”

Section: Idiopathic Pulmonary Fibrosismentioning

confidence: 99%

Expanding the Spectrum of Particle-and Fiber-Associated Interstitial Lung Diseases

Ghio¹

2014

Tur Toraks Der

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While interstitial lung disease (ILD) is common, less than five percent of diagnoses appear to be related to occupational and environmental exposures to particles and fibers; these injuries are most frequently recognized as pneumoconioses and hypersensitivity pneumonitides. As a result of this small contribution to recognized ILD, the association of particles and fibers with this group of diseases is frequently deemed of little consequence. However, it has been proposed that some portion of ILD without a recognized cause (i.e. idiopathic disease) can also be related to exposures to particles and fibers. Many of these diagnoses are determined without benefit of microscopic examination of lung tissue. Even when tissue is available, the conventional examination for the presence of particles and fibers is used. This approach employing optical microscopy is insensitive and leads to misdiagnosis. A review of previous investigation demonstrates associations of idiopathic pulmonary fibrosis, desquamative interstitial pneumonia, pulmonary alveolar proteinosis, sarcoidosis, and eosinophilic granuloma with particle and fiber exposures. It is recommended that scanning electron microscopy in combination with the use of electron dispersive X-ray analysis be employed whenever the question of a possible relationship between ILD and particle and fiber exposure arises.

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What causes cryptogenic fibrosing alveolitis? A case-control study of environmental exposure to dust.

Cited by 211 publications

References 11 publications

Biomass smoke exposure as a serious health hazard for women

Biomass smoke exposure as a serious health hazard for women

Increased Prevalence of High Anti-<i>Cladosporium</i> Antibody Titers in Interstitial Lung Diseases

Expanding the Spectrum of Particle-and Fiber-Associated Interstitial Lung Diseases

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