What Causes Death in Esophageal Cancer Patients Other Than the Cancer Itself: A Large Population-Based Analysis

Zheng, Xueer; Zhang, Anlai; Xiao, Yao; Guo, Kaibo; Sun, Leitao; Ruan, Shanming; Fang, Fang

doi:10.7150/jca.78004

Cited by 5 publications

(6 citation statements)

References 47 publications

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“…As mentioned above, the higher risk of severe complications in lung cancer may be explained by the etiology and treatment regimen. Higher risks of infection have also been suggested in esophageal cancer (Kawasaki et al 2021;Zheng et al 2022). Higher chances of radiotherapy may also increase the risk of infection and ARF in esophageal cancer (Terrones-Campos et al 2022).…”

Section: Discussionmentioning

confidence: 99%

Characteristics and outcomes of cancer patients admitted to intensive care units in cancer specialized hospitals in China

Liu,

Zhou,

Zhang

et al. 2024

J Cancer Res Clin Oncol

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Purpose Standard intensive care unit (ICU) admission policies and treatment strategies for patients with cancer are still lacking. To depict the current status of admission, characteristics, and outcomes of patients with cancer in the ICU. Methods A multicenter cross-sectional study was performed from May 10, 2021 to July 10, 2021, in the ICU departments of 37 cancer-specialized hospitals in China. Clinical records of all admitted patients aged ≥ 14 years and ICU duration > 24 h with complete data were included. Demographic information, clinical history, severity score at admission, ICU critical condition diagnosis and treatment, ICU and in-hospital outcomes and 90 days survival were also collected. A total of 1455 patients were admitted and stayed for longer than 24 h. The most common primary cancer diagnoses included lung, colorectal, esophageal, and gastric cancer. Results Patients with lung cancer were admitted more often because of worsening complications that occurred in the clinical ward. However, other cancer patients may be more likely to be admitted to the ICU because of postoperative care. ICU-admitted patients with lung or esophageal cancer tended to have more ICU complications. Patients with lung cancer had a poor overall survival prognosis, whereas patients with colorectal cancer appeared to benefit the most according to 90 days mortality rates. Conclusion Patients with lung cancer require more ICU care due to critical complications and the overall survival prognosis is poor. Colorectal cancer may benefit more from ICU management. This information may be considered in ICU admission and treatment strategies.

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Section: Discussionmentioning

confidence: 99%

Characteristics and outcomes of cancer patients admitted to intensive care units in cancer specialized hospitals in China

Liu,

Zhou,

Zhang

et al. 2024

J Cancer Res Clin Oncol

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“…A large number of studies on COD and survival of cancer patients have been carried out, most of which focusing on only 1 malignancies. [13][14][15][16][17][18][19] Our study is unique as it explored specific COD and prognosis of 4 malignancies in hepota-biliary-pancreatic system using newest large-cohort from SEER database.…”

Section: Discussionmentioning

confidence: 99%

“…Same phenomenon occurred in other cancer patients, such as prostate cancer, esophageal cancer, laryngeal cancer and endometrial cancer. [13][14][15][16][17] There have been many studies on cancer complicated with cardiovascular disease (CVD, in SEER 17 registries including diseases of heart, cerebrovascular disease, atherosclerosis, hypertension without heart disease, other diseases of arteries, arterioles, capillaries, and aortic aneurysm and dissection). Cancer and CVD have become the major causes of death in the past 30 years all over the world.…”

Section: Discussionmentioning

confidence: 99%

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Causes of death and nomogram for patients with oncologic hepato-biliary-pancreatic disorders: A large-cohort study

Xu,

Huang,

Yan

et al. 2024

Medicine

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The improvement of digestive cancer survival results in increased morbidity of noncancerous comorbidities. This study aimed at clarifying causes of death (COD) and predicting overall survival (OS) in patients diagnosed with liver cancer, gallbladder cancer, cholangiocarcinoma, and pancreatic cancer. We used the Surveillance, Epidemic, and End Results database to extract information. Nomograms of multivariate Cox regression was used to predict OS of cancer patients. The models were evaluated using the concordance indexes (C-indexes), the receiver operating characteristic curves and calibration curves. Respectively 58,895, 15,324, 30,708, and 109,995 cases with cancer of liver, gallbladder, bile duct or pancreas were retrieved between 2000 and 2020. Approximately 80% deaths occurred within 1 years after cancer diagnosis. Sequence in noncancerous COD proportion was diverse, while diseases of heart always accounted for a great part. Risks of death from most noncancerous COD were significantly higher than that of the cancer-free population. Nomograms were developed by predictors of interest such as age, therapy and TNM stage. The concordance indexes of nomograms were 0.756, 0.729, 0.763, and 0.760 respectively, well-calibrating to the reality. The 0.5-, 1-, and 2-year areas under the receiver operating characteristic curve were about 0.800, indicating good reliability and accuracy. Noncancerous COD accounted for larger part in gallbladder cancer and cholangiocarcinoma. Noncancerous COD showed an upward trend as follow-up time extended and the majorities were diseases of heart, cerebrovascular disease, chronic liver disease and cirrhosis. The novel OS-nomograms can provide personalized prognosis information with satisfactory accuracy.

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“…An SMR value ( P < .05, 2-sided) greater than one indicates an increased risk of dying from this specific COD. [7]…”

Section: Methodsmentioning

confidence: 99%

Cause of death among gastric cancer survivors in the United States from 2000 to 2020

Liao,

Xu,

Huang

et al. 2024

Medicine

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A number of studies have been conducted to explore the survival of gastric cancer (GC) patients, while studies about non-cancer causes of death in patients with GC are not well-conducted. The aim of this study was to deeply investigate the causes of death (COD) in GC patients, especially non-cancer ones. The Surveillance, Epidemiology and End Results (SEER) database was used to extract information including demographics, tumor characteristics and causes of death of GC patients meeting the inclusion criteria. The patients were stratified by demographic and clinical parameters. Standardized mortality ratios (SMRs) were calculated for all causes of death at different follow-up periods. A total of 116,437 patients with GC diagnosed between 2000 and 2020 were retrieved from the SEER database. Of these, 85,827 deaths occurred during the follow-up period, most of which occurred within 1 year after GC diagnosis. GC (n = 49,746; 58%) was the leading COD, followed by other cancer (n = 21,135; 25%) and non-cancer causes (n = 14,946; 17%). Diseases of heart were the most common non-cancer cause of death, accounting for 30%, followed by cerebrovascular diseases (n = 917; 6%) and chronic obstructive pulmonary disease (n = 900; 6%). Although gastric cancer remains the most common cause of death in gastric cancer patients, it should not be ignored that the risk of non-cancer causes tends to increase with the length of the latency period. These findings may provide important insights into the healthcare management of gastric cancer patients at various follow-up intervals.

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What Causes Death in Esophageal Cancer Patients Other Than the Cancer Itself: A Large Population-Based Analysis

Cited by 5 publications

References 47 publications

Characteristics and outcomes of cancer patients admitted to intensive care units in cancer specialized hospitals in China

Characteristics and outcomes of cancer patients admitted to intensive care units in cancer specialized hospitals in China

Causes of death and nomogram for patients with oncologic hepato-biliary-pancreatic disorders: A large-cohort study

Cause of death among gastric cancer survivors in the United States from 2000 to 2020

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