What Do I Need to Know About Long-Covid-related Fatigue, Brain Fog, and Mental Health Changes?

Gross, Monika; Lansang, Noemi Maureen; Gopaul, Urvashy; Ogawa, Elisa; Heyn, Patricia; Santos, Flávia Heloísa; Gardner-Sood, Poonam; Zanwar, Preeti; Schwertfeger, Julie; Faieta, Julie

doi:10.1016/j.apmr.2022.11.021

Cited by 10 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Current care recommendations include multidisciplinary rehabilitation, self-management and self-pacing ( 42–44 ). Self-management approaches include appropriate rest, practicing good sleep hygiene, energy pacing methods, diet control, and distraction ( 41 , 42 , 45 ). Pacing strategies are aimed at coping with inconsistent and decreased energy levels by adapting or adjusting efforts to different activities ( 43 ).…”

Section: Managementmentioning

confidence: 99%

“…The most common neuropsychiatric symptoms in long COVID include depression, anxiety, sleep disturbances, parosmia, and cognitive impairment ( 58 , 59 ). “Brain fog” is a term used by patients to describe their cognitive impairment experience and may include any of the following: concentration difficulty, feelings of confusion, cognitive slowing, mental fuzziness, forgetfulness, word finding, mental fatigue ( 45 , 59 ).…”

Section: Managementmentioning

confidence: 99%

See 1 more Smart Citation

Long COVID management: a mini review of current recommendations and underutilized modalities

Dietz,

Brondstater

2024

Front. Med.

View full text Add to dashboard Cite

Long COVID is a condition that develops in a subset of patients after COVID-19 infection comprising of symptoms of varying severity encompassing multiple organ systems. Currently, long COVID is without consensus on a formal definition, identifiable biomarkers, and validated treatment. Long COVID is expected to be a long-term chronic condition for a subset of patients and is associated with suffering and incapacity. There is an urgent need for clear management guidelines for the primary care provider, who is essential in bridging the gap with more specialized care to improve quality of life and functionality in their patients living with long COVID. The purpose of this mini review is to provide primary care providers with the latest highlights from existing literature regarding the most common long COVID symptoms and current management recommendations. This review also highlights the underutilized interventions of stellate ganglion blocks and low-dose naltrexone, both with well-established safety profiles demonstrated to improve quality of life and functionality for patients suffering with some symptoms of long COVID, and encourages prompt referral to interventional pain management.

show abstract

Section: Managementmentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

Long COVID management: a mini review of current recommendations and underutilized modalities

Dietz,

Brondstater

2024

Front. Med.

View full text Add to dashboard Cite

show abstract

“…1 Cognitive impairment and fatigue are relevant to the health-related quality of life (HRQOL) and functioning of individuals with PCC; however, the extent of contribution from each domain is under-studied. 1,7,8 Understanding their respective contributions to HRQOL holds implications for early interventions, the discovery and development of treatments, clinical care planning, and the characterization of mechanistic models in PCC. In this post-hoc study of a randomized controlled trial, we sought to determine the respective impacts of objective cognitive function (e.g., motor speed, attention, and visuoperceptual functions) and fatigue on measures of HRQOL in individuals with PCC.…”

Section: Introductionmentioning

confidence: 99%

Greater Role of Cognitive Impairment Over Fatigue in Post-COVID-19 Quality of Life: A Post-Hoc Analysis of a Randomized Controlled Trial

Kwan,

Lakhani,

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Post COVID-19 Condition (PCC) is a common and debilitating condition with significant reports of fatigue and psychosocial impairment globally. The extent to which cognitive symptoms and fatigue contribute to reduced quality of life in affected individuals remains clear. Methods This is a post-hoc analysis of a randomized, double-blind, placebo-controlled clinical trial that evaluated the effect of vortioxetine on cognitive function in adults with PCC. The post-hoc analysis herein aimed to determine the overall effect of baseline cognitive function [as measured by the Digit Symbol Substitution Test (DSST)] and baseline fatigue severity [as measured by the Fatigue Severity Scale (FSS)] on baseline health-related quality of life (HRQoL) [as measured by the 5-item World Health Organisation Well-Being Index (WHO-5)]. Results A total of 200 participants were enrolled in the primary trial. Due to missing baseline data, our statistical analysis included baseline measures of 147 individuals. Our generalized linear model analysis revealed a significant positive correlation between DSST-measured objective cognitive function and self-reported WHO-5-measured HRQoL (beta; = 0.069, 95% CI [0.006, 0.131], p = 0.032). In contrast, our analysis revealed a significant negative correlation between FSS and WHO-5 scores (beta; = -0.016, 95% CI [-0.021, -0.011], p < 0.001). The beta-coefficient ratio (beta;DSST / beta;FSS = 0.069 / 0.016) is calculated as 4.313. Conclusions Overall, we observed that increased cognitive function was associated with increased HRQoL at baseline in adults with PCC. Moreover, we observed that increased severity of fatigue symptoms was associated with decreased HRQoL at baseline in adults with PCC. Furthermore, we observed that an improvement in cognitive function would have a four-fold greater impact on HRQoL than the effect generated by improvement in fatigue.

show abstract

ACRM Long Covid Information Forgot the “RM” Part?

Haig

2023

Archives of Physical Medicine and Rehabilitation

View full text Add to dashboard Cite

What Do I Need to Know About Long-Covid-related Fatigue, Brain Fog, and Mental Health Changes?

Cited by 10 publications

References 22 publications

Long COVID management: a mini review of current recommendations and underutilized modalities

Long COVID management: a mini review of current recommendations and underutilized modalities

Greater Role of Cognitive Impairment Over Fatigue in Post-COVID-19 Quality of Life: A Post-Hoc Analysis of a Randomized Controlled Trial

ACRM Long Covid Information Forgot the “RM” Part?

Contact Info

Product

Resources

About