This research aims to determine the opinions of high school students about the Physics and Chemistry courses during the distance education due to the Covid-19 pandemic. 88 students who study in two public schools in Bursa were included in the research by determining through purposive sampling. In the research, we used a special case research design, one of the qualitative research methods, and semi-structured documents containing six open-ended questions we created as a data collection tool. When evaluating the data obtained using content analysis, we found that most participants stated they had difficulties in the problem-solving process in physics and chemistry and could not conduct an experiment. In addition, students talked about the advantages of taking these courses with distance education, such as listening comfortably in a quiet home environment, getting individual education, time to review the lesson, discipline, health, and economy. They also mentioned the disadvantages as not being able to focus on the lesson, not understanding the courses, experiencing internet and technical problems, and not socializing.