2018
DOI: 10.1111/ajad.12783
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What do we know about the pharmacotheraputic management of insomnia in cannabis withdrawal: A systematic review

Abstract: Background and Objectives Sleep disturbance is one of the hallmarks of cannabis withdrawal. Studies have indicated that treatment of this key symptom may facilitate abstinence. In the present paper we aim to provide a systematic review of the extant literature on pharmacological management of sleep disturbance associated with cannabis withdrawal. Method We conducted a systematic literature search across five electronic databases including PubMed, Psycinfo, MEDLINE, Cochrane review and Embase. Human studies usi… Show more

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Cited by 12 publications
(4 citation statements)
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“…Sleep disturbances are a hallmark symptom of cannabis withdrawal. 31 Sleep difficulty during attempts to discontinue use of cannabis is reported by 67% to 73% of adults. 5 , 32 , 33 Furthermore, sleep difficulty has been consistently rated as one of the most severe symptoms of cannabis withdrawal.…”
Section: Discussionmentioning
confidence: 99%
“…Sleep disturbances are a hallmark symptom of cannabis withdrawal. 31 Sleep difficulty during attempts to discontinue use of cannabis is reported by 67% to 73% of adults. 5 , 32 , 33 Furthermore, sleep difficulty has been consistently rated as one of the most severe symptoms of cannabis withdrawal.…”
Section: Discussionmentioning
confidence: 99%
“…The latter authors note that THC preparations qualitatively seemed to diminish withdrawal symptoms [113][114][115][116], a finding supported by another systematic review on cannabinoid agonist replacement therapy [117]. A final systematic review on the accompanying sleep disturbance associated with cannabis withdrawal that may support abstinence also found insufficient evidence of a pharmacological treatment option [118].…”
Section: Cannabis Withdrawalmentioning
confidence: 98%
“…Although the multivariate analyses clearly indicated that the trend level for “any relapse” was driven by confounders, this is an intriguing result in the opposite direction of what one may have expected. One could speculate whether discontinuing cannabis use may trigger (hypo)mania through e.g., neuroadaptive effects or indirectly through withdrawal symptoms such as insomnia ( 25 ). The current findings of no significant differences in relapse rates between the cannabis misuse groups are in contrast to our previous finding of a relationship between continued cannabis use and higher levels of manic symptoms at follow-up ( 12 ).…”
Section: Discussionmentioning
confidence: 99%