What do we know about metabolic syndrome in adolescents with PCOS?

Cırık, Derya Akdağ; Dilbaz, Berna

doi:10.5152/jtgga.2014.95776

Cited by 31 publications

(24 citation statements)

References 57 publications

(43 reference statements)

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“…The treatment of hirsutism consists of management of expectations, destruction of terminal hair growth through cosmetic actions and prevention of terminal hair growth (70). As we previously discussed, obese adolescents with PCOS who achieved a modest weight loss through a lifestyle intervention (diet, exercise and behaviour modifications) restores menstrual cycles with the reductions in free androgen index levels and increases in SHBG concentrations (75)(76)(77)(78)(79)(80)86). Besides non-pharmacological therapy (weight loss through dietary or lifestyle modification and mechanical/ physical hair removal), OCPs remain the first-line treatment for hirsutism (87).…”

Section: Hirsutismmentioning

confidence: 99%

Adolescence and polycystic ovary syndrome: current concepts on diagnosis and treatment

Spritzer

Motta

2015

Int J Clin Pract

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Section: Hirsutismmentioning

confidence: 99%

Adolescence and polycystic ovary syndrome: current concepts on diagnosis and treatment

Spritzer

Motta

2015

Int J Clin Pract

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“…Polycystic ovary syndrome consists of a set of criteria including hyperandrogenism (clinical or biochemical), ovulatory dysfunction, and polycystic ovaries (Anderson, Solorzano, & McCartney, 2014;Cirik & Dilbaz, 2014). "Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age and is increasingly recognized as a disorder manifesting in the peripubertal and adolescent period" (Hardy & Norman, 2013, p. 751).…”

Section: Polycystic Ovary Syndromementioning

confidence: 99%

“…Youth with PCOS are at a higher risk for development of co-morbidities associated with obesity such as impaired glucose metabolism and cardiovascular disease (Legro et al, 2013). Women with PCOS exhibiting central adiposity are at higher risk for development of metabolic syndrome (Cirik & Dilbaz, 2014). All adolescents diagnosed with PCOS should have a BMI and waist circumference monitored at each visit (Legro et al, 2013).…”

Section: Polycystic Ovary Syndromementioning

confidence: 99%

Insulin Resistance, Metabolic Syndrome, and Polycystic Ovary Syndrome in Obese Youth

Platt

2015

NASN School Nurse

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School nurses are well aware of the childhood obesity epidemic in the United States, as one in three youth are overweight or obese. Co-morbidities found in overweight or obese adults were not commonly found in youth three decades ago but are now increasingly "normal" as the obesity epidemic continues to evolve. This article is the second of six related articles discussing the co-morbidities of childhood obesity and discusses the complex association between obesity and insulin resistance, metabolic syndrome, and polycystic ovary syndrome. Insulin resistance increases up to 50% during puberty, which may help to explain why youth are more likely to develop co-morbidities as teens. Treatment of these disorders is focused on changing lifestyle habits, as a child cannot change his or her pubertal progression, ethnicity, or family history. School nurses and other personnel can assist youth with insulin resistance, metabolic syndrome, and polycystic ovary syndrome by supporting their efforts to make changes, reinforcing that insulin resistance is not necessarily type 2 diabetes even if the child is taking medication, and intervening with negative peer pressure.

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“…Clinical observations have indicated a solid association between obesity and infertility in females (1). Obese women suffer from insulin and leptin resistance, inducing hyperandrogenemia, modulation of steroidogenesis and polycystic ovaries syndrome (PCOS) (2)(3)(4)(5). Obesity increases systemic inflammation and disturbs the reproductive functions via negative effects on the ovaries (2).…”

Section: Introductionmentioning

confidence: 99%

Evening Primrose Oil Ameliorates Hyperleptinemia and Reproductive Hormone Disturbances in Obese Female Rats: Impact on Estrus Cyclicity

et al. 2020

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Obesity is a public health burden disturbing all body functions and reproductive hormones. As obesity increases among females, there will be a rising challenge to physicians in care from fertility problems. Evening primrose oil (EPR oil) contains essential fatty acids including omega-6 linoleic acid with strong anti-inflammatory activity.Since EPR oil has utility in alleviating dysmenorrhea, this study aimed to ascertain its modulatory effect on systemic inflammation, reproductive hormones and estrus cycle irregularity in female obese rats. Thirty-two female rats were distributed to 4 groups: (i) normal, (ii) dietary obese-control female rats, and (iii and iv) dietary obese female rats treated with EPR oil (5 or 10 g/kg). Rats were examined for estrus regularity by taking vaginal smears daily during the last 2 weeks of the experiment. Serum level of insulin, leptin, adiponectin, and inflammatory cytokines was measured. In addition, serum lipid profile, and liver enzyme activities were estimated. Adipose tissues were taken for histopathologic examination as well as determination of gene expression for leptin, leptin receptors, adiponectin, and visfatin. Obese rats exhibited significant weight gain (90.69 ± 8.9), irregular prolonged estrus cycles (83.33%), increased serum levels of insulin, leptin, prolactin and testosterone and decreased gonadotropin levels. EPR oil exhibited a curative effect on obesity-related irregularity in estrus cycle and ovarian pathology. The underlying molecular mechanism may be related to reduction of systemic inflammation, alleviating insulin resistance and modulation of adipokine expression. EPR oil may be considered as a promising therapeutic intervention against obesity-related female hormonal disturbances and estrus irregularity.

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What do we know about metabolic syndrome in adolescents with PCOS?

Cited by 31 publications

References 57 publications

Adolescence and polycystic ovary syndrome: current concepts on diagnosis and treatment

Adolescence and polycystic ovary syndrome: current concepts on diagnosis and treatment

Insulin Resistance, Metabolic Syndrome, and Polycystic Ovary Syndrome in Obese Youth

Evening Primrose Oil Ameliorates Hyperleptinemia and Reproductive Hormone Disturbances in Obese Female Rats: Impact on Estrus Cyclicity

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