What do we know about resistance to colistin in Enterobacteriaceae in avian and pig production in Europe?

Kempf, Isabelle; Fleury, Mickaël; Drider, Djamel; Bruneau, Mireille; Sandérs, Pascal; Chauvin, Claire; Madec, Jean‐Yves; Jouy, Éric

doi:10.1016/j.ijantimicag.2013.06.012

Cited by 135 publications

(105 citation statements)

References 27 publications

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“…Finally, the full susceptibility to colistin observed in E. coli is valuable both for poultry and human concerns, since this agent is widely used in poultry production and represents a last-resort treatment in human medicine (Livermore, 2004). In accordance with our results, colistin resistance seems to be extremely rare (<1%) in healthy animals, including poultry, in Europe (Kempf et al, 2013b). The resistance to the majority of antimicrobials tested in this study is known to be conferred by the acquisition of foreign resistance genes through horizontal transfer, which usually emerges in the presence of antimicrobial selective pressure and involves not only pathogenic but also commensal bacteria (Schwarz et al, 2006;van Hoek et al, 2011).…”

Section: Discussionsupporting

confidence: 88%

Antimicrobial resistance and class 1 and 2 integrons inEscherichia colifrom meat turkeys in Northern Italy

Piccirillo¹,

Giovanardi²,

Dotto³

et al. 2014

Avian Pathology

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This study is aimed at determining the antimicrobial resistance (AMR) and the presence of class 1 and 2 integrons in 48 avian pathogenic Escherichia coli (APEC) strains isolated from meat turkeys during three sequential production cycles. Thirty avian faecal E. coli (AFEC) strains from the first cycle were also analysed. Strains were tested for AMR against 25 antimicrobials by disk diffusion test and were screened for the presence of integrons and associated gene cassettes by polymerase chain reaction followed by sequencing. Genetic relatedness of isolates was established by pulsed-field gel electrophoresis. High levels of resistance were detected to tetracyclines, penicillins and sulphonamides in APEC and AFEC. Resistance to aminoglycosides, fluoroquinolones, cephalosporins and phenicols was variable, based on the antimicrobial drug and the isolate (APEC vs. AFEC). Full susceptibility to colistin was detected. Multidrug resistance of up to seven antimicrobial classes was exhibited by APEC (93.8%) and AFEC (100%). Nearly 44% of strains tested positive for class 1 and/or class 2 integrons containing the dfrA, aadA and sat2 genes, alone or in combination, coding for streptomycin/spectinomycin, trimethoprim and streptothricin resistance, respectively. The estX and orfF genes of unknown function were also detected. A significant association was found between the presence of integrons and the resistance to aminoglycosides and potentiated sulphonamides. The results of this study showed that AMR, multidrug resistance and class 1 and 2 integrons are widespread among pathogenic and commensal E. coli from Italian turkeys. More attention should be addressed to limit the use of antimicrobials in turkeys and the AMR of turkey E. coli.

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Section: Discussionsupporting

confidence: 88%

Antimicrobial resistance and class 1 and 2 integrons inEscherichia colifrom meat turkeys in Northern Italy

Piccirillo¹,

Giovanardi²,

Dotto³

et al. 2014

Avian Pathology

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“…Despite this extensive use in veterinary medicine, the resistance rate to colistin in E. coli strains recovered from healthy animals remains Ͻ1% in many European countries (62). However, resistance to colistin has increasingly been reported (10%) among porcine-pathogenic E. coli strains in Belgium (63), and the emergence of resistance has been described for cattle (64).…”

Section: Use In Veterinary Medicinementioning

confidence: 99%

Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes

2017

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SUMMARY Polymyxins are well-established antibiotics that have recently regained significant interest as a consequence of the increasing incidence of infections due to multidrug-resistant Gram-negative bacteria. Colistin and polymyxin B are being seriously reconsidered as last-resort antibiotics in many areas where multidrug resistance is observed in clinical medicine. In parallel, the heavy use of polymyxins in veterinary medicine is currently being reconsidered due to increased reports of polymyxin-resistant bacteria. Susceptibility testing is challenging with polymyxins, and currently available techniques are presented here. Genotypic and phenotypic methods that provide relevant information for diagnostic laboratories are presented. This review also presents recent works in relation to recently identified mechanisms of polymyxin resistance, including chromosomally encoded resistance traits as well as the recently identified plasmid-encoded polymyxin resistance determinant MCR-1. Epidemiological features summarizing the current knowledge in that field are presented.

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“…Field studies have shown that it is used primarily for pigs including group treatments and prevention of diarrhoea caused by Escherichia coli and Salmonella spp., as first-choice treatments for neonatal diarrhoea caused by E. coli in piglets [51,52] and veal calves [53] as well as for the therapy of mild colibacillosis in poultry [54]. Studies conducted in Belgium describe how colistin has been used for indications other than those for which it is authorised, e.g., respiratory disease, peritonitis [53] and streptococcal infections [52].…”

Section: Veterinary Medicinementioning

confidence: 99%

Use of colistin-containing products within the European Union and European Economic Area (EU/EEA): development of resistance in animals and possible impact on human and animal health

Catry

Cavaleri²,

Baptiste

et al. 2015

International Journal of Antimicrobial Agents

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207

153

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What do we know about resistance to colistin in Enterobacteriaceae in avian and pig production in Europe?

Cited by 135 publications

References 27 publications

Antimicrobial resistance and class 1 and 2 integrons inEscherichia colifrom meat turkeys in Northern Italy

Antimicrobial resistance and class 1 and 2 integrons inEscherichia colifrom meat turkeys in Northern Italy

Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes

Use of colistin-containing products within the European Union and European Economic Area (EU/EEA): development of resistance in animals and possible impact on human and animal health

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