The process of prescribing changes as children move into adulthood. For some medicines, such as psychotropic drugs, safety and efficacy are less well understood in adolescents. As adolescents mature they attain the capacity to consent to their own medical treatment. An assessment of their competency will need to take into account the nature of the treatment being proposed. Parental involvement is usually beneficial particularly for adolescents with chronic or complex conditions, but increasing adolescent autonomy needs to be respected. Adherence to treatment can be supported by understanding adolescent development and involving adolescents in management plans. For antidepressants, current evidence shows a modest benefit for only one drug in this age group (fluoxetine). 6 There are also concerns about the risk of harm. Mild to moderate depression should be treated with non-pharmacological therapy. Decision making regarding psychotropic drugs requires careful consideration. A thorough assessment of mental health symptoms, a comprehensive biopsychosocial assessment, 7 and a risk and safety assessment are warranted. Drug therapy is more likely to be indicated