The Organization for Security and Co-operation in Europe (OSCE), while primarily a security organisation, has always included economic and human baskets or dimensions. Currently, the Office of the Co-ordinator of OSCE Economic and Environmental Activities operates in four main areas: (1) good governance and anti-corruption, (2) money laundering and financing of terrorism, (3) transport, trade and border-crossing facilitation, and (4) labour migration. This chapter addresses developments in Central Asia since the dissolution of the Soviet Union that are relevant to the third area of OSCE operations. The chapter’s focus is on the potential for the landlocked Central Asian countries to become land-linked, using improved transport connections between East Asia and Europe to promote economic development through export diversification and growth. Rail services across Central Asia improved considerably during the 2010s. They have been resilient, despite strained political relations between Russia and the EU since 2014, and rail traffic between Europe and China continued to increase in 2020 despite the shock of COVID-19. Further infrastructure improvements are promised under China’s Belt and Road Initiative. However, the expanded network has been little used by Central Asian producers to create new international trade, and the improved infrastructure represents a potential opportunity rather than a past benefit. If the Central Asian economies are successful in taking advantage of the opportunity, it will stimulate their trade across the Eurasian region and help economic diversification. The main determinant of success will be national policies and national economic development. The chapter concludes with a discussion of the role of multilateral institutions and, in particular, the prospects for OSCE collaboration with existing fora to promote cooperation and economic development in Central Asia.