What does the HAMD mean?

Leucht, Stefan; Fennema, Hein; Engel, Rolf R.; Kaspers-Janssen, Marion; Lepping, Peter; Szegedi, Armin

doi:10.1016/j.jad.2012.12.001

Cited by 174 publications

(138 citation statements)

References 21 publications

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“…Widely used and well validated instruments, HAMD-17 and CGI-S (Leucht et al, 2013) were used to assess depression and overall clinical severity in our study. Another well-established and widely used generic instrument, the EQ-5D (Herdman et al, 2011) was used to assess QOL.…”

Section: Discussionmentioning

confidence: 99%

Impact of painful physical symptoms on depression outcomes in elderly Asian patients

Novick

Montgomery²,

Bertsch

et al. 2014

Int. Psychogeriatr.

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Background: Painful physical symptoms (PPS) are prevalent among elderly patients with depression. We describe the impact of PPS on depression outcomes and quality of life (QOL) of elderly Asian patients with major depressive disorder (MDD). Methods: This post hoc analysis of data from a three-month prospective observational study of East Asian MDD in- or out-patients focused on elderly patients aged ≥60 years. Depression severity was evaluated using the Hamilton depression (HAMD-17) and clinical global impression of severity (CGI-S) scales, while QOL was measured using EuroQOL (EQ-5D and EQ-VAS) instruments. PPS were rated using the modified somatic symptom inventory (SSI). Results: At baseline, depression was moderate to severe and 49% of the 146 elderly patients were painful physical symptom positive (PPS+). Bivariate analysis showed significant correlations between PPS and depression severity and QOL at baseline. Linear regression models showed the baseline factor most significantly associated with depression severity at three months was baseline PPS status. PPS+ patients had a mean increase of 2.87 points in their HAMD-17 rating and 0.77 points in their CGI-S score. Response and remission were significantly lower in PPS+ patients; response was 60% and remission was 40% in PPS+ patients while 82% and 66% in painful physical symptom negative (PPS-) patients. QOL at endpoint was lower in PPS+ patients. Conclusions: PPS are common in elderly Asian patients with MDD and negatively influence depression outcomes and QOL. Patients with PPS had lower QOL at baseline, lower response and remission rates, higher severity of depression, and lower QOL after three months of treatment.

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Section: Discussionmentioning

confidence: 99%

Impact of painful physical symptoms on depression outcomes in elderly Asian patients

Novick

Montgomery²,

Bertsch

et al. 2014

Int. Psychogeriatr.

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“…22 We included women with HAM-D-17 scores of 8 or more to include non-euthymic women in the sample and capture a range of symptom severity. 26 For women who completed symptom assessments at multiple points in the postpartum period, we used data for the most severe episode.…”

Section: Methodsmentioning

confidence: 99%

Heterogeneity of postpartum depression: a latent class analysis

2015

The Lancet Psychiatry

220

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Summary Background Maternal depression in the postpartum period confers substantial morbidity and mortality, but the definition of postpartum depression remains controversial. We investigated the heterogeneity of symptoms with the aim of identifying clinical subtypes of postpartum depression. Methods Data were aggregated from the international perinatal psychiatry consortium Postpartum Depression: Action Towards Causes and Treatment, which represents 19 institutions in seven countries. 17 912 unique subject records with phenotypic data were submitted. We applied latent class analyses in a two-tiered approach to assess the validity of empirically defined subtypes of postpartum depression. Tier one assessed heterogeneity in women with complete data on the Edinburgh postnatal depression scale (EPDS) and tier two in those with postpartum depression case status. Findings 6556 individuals were assessed in tier one and 4245 in tier two. A final model with three latent classes was optimum for both tiers. The most striking characteristics associated with postpartum depression were severity, timing of onset, comorbid anxiety, and suicidal ideation. Women in class 1 had the least severe symptoms (mean EPDS score 10·5), followed by those in class 2 (mean EPDS score 14·8) and those in class 3 (mean EPDS score 20·1). The most severe symptoms of postpartum depression were significantly associated with poor mood (mean EPDS score 20·1), increased anxiety, onset of symptoms during pregnancy, obstetric complications, and suicidal ideation. In class 2, most women (62%) reported symptom onset within 4 weeks postpartum and had more pregnancy complications than in other two classes (69% vs 67% in class 1 and 29% in class 3). Interpretation PPD seems to have several distinct phenotypes. Further assessment of PPD heterogeneity to identify more precise phenotypes will be important for future biological and genetic investigations. Funding Sources of funding are listed at the end of the article.

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“…5 Ask your doctor whether he or she receives money or other benefits from the industry, has shares in a company or is visited by drug salespeople, or is being "educated" at industry sponsored events, and if so, find yourself another doctor. 6 Withdraw your membership if your patient organization accepts industry favors. 7 Remind yourself constantly that we cannot believe a word of what drug companies tell us, neither in their research nor in their marketing or information to patients.…”

Section: Resultsmentioning

confidence: 99%

Our prescription drugs kill us in large numbers

Gøtzsche¹

2014

Polish Archives of Internal Medicine

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What does the HAMD mean?

Cited by 174 publications

References 21 publications

Impact of painful physical symptoms on depression outcomes in elderly Asian patients

Impact of painful physical symptoms on depression outcomes in elderly Asian patients

Heterogeneity of postpartum depression: a latent class analysis

Our prescription drugs kill us in large numbers

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