What factors are related to delayed treatment in individuals at high risk for psychosis?

Chung, Young‐Chul; Jung, Hee-Yeon; Kim, Sung‐Wan; Lee, Seung Hwan; Shin, Sang-Eun; Shin, Yunmi; Park, Jong-Ik; An, Suk Kyoon; Kim, Young-Hoon

doi:10.1111/j.1751-7893.2010.00170.x

Cited by 24 publications

(21 citation statements)

References 36 publications

(49 reference statements)

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“…Based on these or similar criteria, studies with followup times ranging from 1 to 9.6 years report a transition rate to full psychotic syndromes of 9 -54% (Amminger et al, 2006;Olsen and Rosenbaum, 2006;Chung et al, 2010). A 2-year follow-up study of 292 help-seeking individuals found a transition rate of 16%, which is considerably lower than the rates reported in earlier studies (over 40%) (Yung et al, 2008).…”

Section: Transition From Health To Psychosis: the Ultra-high-risk Statementioning

confidence: 86%

N-acetylcysteine as a potentially useful medication to prevent conversion to schizophrenia in at-risk individuals

Asevedo

Cunha

Zugman

et al. 2012

Reviews in the Neurosciences

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Schizophrenia is a chronic and often severe psychotic disorder. Its causes include imbalances in mediators involved in neuroplasticity, apoptosis, cell resilience and dendritic arborization. Among these mediators, oxidative species are particularly relevant for the pathophysiology of the disease, and this is the rationale for experimental use of antioxidant medications, such as N-acetylcysteine (NAC). Onset of schizophrenia is usually preceded by a period of subtle and unspecific symptoms, the prodrome, in which preventive interventions could delay or even stop the progression to full-blown psychosis. In this article, we propose that NAC could be a useful medication to prevent evolution of schizophrenia in individuals at risk for psychosis.

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Section: Transition From Health To Psychosis: the Ultra-high-risk Statementioning

confidence: 86%

N-acetylcysteine as a potentially useful medication to prevent conversion to schizophrenia in at-risk individuals

Asevedo

Cunha

Zugman

et al. 2012

Reviews in the Neurosciences

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“…Global functioning did not significantly differ between patients with long (N1 year) and short (b1 year) durations of untreated attenuated psychotic symptoms (Chung et al, 2010). However, a longer duration of prodromal symptoms was associated with increased impairment on the 'Interpersonal behaviour' and 'Prosocial activities' subscales of the Social Functioning Scale (Shim et al, 2008a).…”

Section: Duration Of Symptomsmentioning

confidence: 97%

What drives poor functioning in the at-risk mental state? A systematic review

Cotter

Drake

Bucci

et al. 2014

Schizophrenia Research

104

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“…Specifically, the risk for psychosis onset rises dramatically following age 13, and increases with each year of age through adolescence (de Girolamo et al, 2012; Thorup at al., 2007). In clinical high risk (CHR) samples, the prodromal syndrome shows a similar trend, and appears to predate psychosis onset by about a year (Chung et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

The relations of age and pubertal development with cortisol and daily stress in youth at clinical risk for psychosis

Moskow

Addington

Bearden

et al. 2016

Schizophrenia Research

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BACKGROUND Prodromal syndromes often begin in adolescence – a period of neurodevelopmental changes and heightened stress sensitivity. Research has shown elevated stress and cortisol in individuals at clinical high risk (CHR) for psychosis. This cross-sectional study examined relations of age and pubertal status with cortisol and self-reported stress in healthy controls (HCs) and CHR adolescents. It was hypothesized that the relations of age and pubertal stage with cortisol and stress would be more pronounced in CHR youth. METHODS Participants were 93 HCs and 348 CHR adolescents from the North American Prodrome Longitudinal Study (NAPLS). At baseline, measures of stress (Daily Stress Inventory – DSI), Tanner stage (TS), and salivary cortisol were obtained. RESULTS ANCOVA revealed increased DSI scores with age for both groups, and higher DSI scores in CHR adolescents than HCs, with a more pronounced difference for females. Contrary to prediction, with age controlled, HCs showed greater TS-related DSI increases. Analysis of cortisol showed no significant interactions, but a main effect of age and a trend toward higher cortisol in the CHR group. Correlations of cortisol with TS were higher in HC than CHR group. CONCLUSIONS Stress measures increased with age in HC and CHR adolescents, and DSI scores also increased with TS in HCs. The results do not support a more pronounced age or TS increase in stress measures in CHR adolescents, but instead suggest that stress indices tend to be elevated earlier in adolescence in the CHR group. Potential determinants of findings and future directions are discussed.

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What factors are related to delayed treatment in individuals at high risk for psychosis?

Abstract: These findings suggest that high-risk subjects frequently received delayed treatment despite symptomatic distress and functional impairment. No direct evidence supporting the delayed effect of the DUAPS on baseline psychopathology was found.

Cited by 24 publications

References 36 publications

N-acetylcysteine as a potentially useful medication to prevent conversion to schizophrenia in at-risk individuals

N-acetylcysteine as a potentially useful medication to prevent conversion to schizophrenia in at-risk individuals

What drives poor functioning in the at-risk mental state? A systematic review

The relations of age and pubertal development with cortisol and daily stress in youth at clinical risk for psychosis

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