Strengthening families through crisis management in high-risk situations can prevent a catastrophe and save lives. This chapter defines a crisis and high-risk behaviors such as self-harm, suicidality, and harm against others that affect children's safety and disrupt the family system. It discusses the important role that medical professionals play in managing crises in children, youth, and their families. This chapter discusses some of the risk factors that increase the risk of a crisis and protective factors that mitigate and increase resiliency in children and adolescents. Communication strategies and other recommendations for supporting high-risk children and family systems are provided to help support the family system.