1972
DOI: 10.1001/jama.1972.03200230028006
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What is a "Safe" Interval Between Halothane Exposures?

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Cited by 8 publications
(2 citation statements)
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“…This might be avoided by allowing an interval between administrations for synthesis and replacement of new hepatic protein and phospholipid. Studies in animals indicate that this interval should be approximately 4 weeks (Bruce, 1972). In people, the degree of liver dysfunction induced by halothane as evidenced by increased AsA and AlA activity is comparable with that induced by ether and cyclopropane (Little, Barbour & Given, 1958;Collins & Fabian, 1964).…”
Section: H a L O T H A N E -A S S O C I A T E D H E P A T I T I Smentioning
confidence: 99%
“…This might be avoided by allowing an interval between administrations for synthesis and replacement of new hepatic protein and phospholipid. Studies in animals indicate that this interval should be approximately 4 weeks (Bruce, 1972). In people, the degree of liver dysfunction induced by halothane as evidenced by increased AsA and AlA activity is comparable with that induced by ether and cyclopropane (Little, Barbour & Given, 1958;Collins & Fabian, 1964).…”
Section: H a L O T H A N E -A S S O C I A T E D H E P A T I T I Smentioning
confidence: 99%
“…Linde and Bruce reported peak concentrations of 50 ppm halothane around the anesthesiologist (19), while Askrog and Peterson indicated that up to 85 ppm halothane was detected near the anesthesiologist when a nonrebreathing system was used (23). In modern, well ventilated operating rooms, 5-15 ppm halothane could still be detected in the ambient air of the operating room (21)(22)(23)(24)(25). Increased concern was generated in the effects of chronic exposure to low levels of anesthetics, in particular, halothane (13,18,19,21,(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35).…”
mentioning
confidence: 99%