Although misophonia may be a diagnosable disorder, misophonic reactions are common in the general population, and they may shed light on everyday emotional reactions to multi-modal stimuli. We performed an online study of a non-clinical sample to understand the extent to which adults who have misophonic reactions are generally reactive to a range of audio-visual emotion-inducing stimuli. We also hypothesized that musicality might be predictive of one’s emotional reactions to these stimuli because music is an activity that involves strong connections between sensory processing and meaningful emotional experiences. Participants completed self-report scales of misophonia and musicality, and watched videos meant to induce misophonia, autonomous sensory meridian response (ASMR), and musical chills, and responded by clicking a button when they had any sort of emotional reaction. At the end of each video, they rated the emotional valence and arousal of the video. Reactions to misophonia videos were predicted by reactions to ASMR and chills videos, which could indicate that the frequency with which individuals experience emotional responses varies similarly across both negative and positive emotional contexts. Musicality scores did not correlate with measures of misophonia. These findings could reflect a general phenotype of stronger emotional reactivity to meaningful sensory inputs.