What is irritable bowel syndrome?

Whorwell, Peter J.

doi:10.1177/1756283x12461061

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Irritable bowel syndrome (IBS) is a chronic condition consisting of a characteristic set of symptoms relating to abnormal bowel function and sensation in the absence of underlying structural abnormality. These symptoms comprise abdominal discomfort or pain with co‐occurring abnormalities in bowel habit, varying from diarrhea to constipation . Traditionally, these variations in bowel habit are classified into diarrhea‐predominant IBS (IBS‐D), constipation‐predominant IBS (IBS‐C), and mixed IBS (IBS‐M), as defined by the Rome III criteria .…”

Section: Introductionmentioning

confidence: 99%

Irritable bowel syndrome: A comparison of subtypes

Castro

Miller

Carruthers

et al. 2015

J of Gastro and Hepatol

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Section: Introductionmentioning

confidence: 99%

Irritable bowel syndrome: A comparison of subtypes

Castro

Miller

Carruthers

et al. 2015

J of Gastro and Hepatol

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“…The severity of IBS strongly varies and limits the quality of life [3]. Often, a variety of symptoms occur, consisting of abdominal pain, bloating, nausea, an irregular but more frequent urge to defecate, and an altered stool consistency (sometimes switching between softer and harder stool forms) [2,4,5]. After a bowel movement, IBS sufferers lack the feeling of complete emptying [4].…”

Section: Introductionmentioning

confidence: 99%

Potential Causes and Present Pharmacotherapy of Irritable Bowel Syndrome: An Overview

Bokic

Storr²,

Schicho³

2015

Pharmacology

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Background: Irritable bowel syndrome (IBS) is currently one of the most common disorders of the digestive system in the Western society. Almost 2 out of 10 people suffer from IBS with women being more affected than men. IBS is associated with abdominal pain, bloating and altered stool consistency and imposes a heavy burden for the affected patients. Summary: The pathophysiology of IBS remains elusive although potential causes have been suggested, such as a deranged brain-gut signaling, hypersensitivity of visceral sensory afferent fibers, bacterial gastroenteritis, small intestinal bacterial overgrowth (SIBO), genetic alterations and food sensitivity. Targets for the pharmacotherapy of IBS include the serotonergic and opioidergic system, and the microbial population of the gut. Alternative therapies like traditional Chinese medicine have shown some success in the combat against IBS. Key Messages: Many therapeutics for the treatment of IBS have emerged in the past; however, only a few have met up with the expectations in larger clinical trials. Additionally, the multifactorial etiology of IBS and its variety of cardinal symptoms requires an individual set of therapeutics. This review provides a short overview of potential causes and current pharmacological therapeutics and of additional and alternative therapies for IBS.

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What is irritable bowel syndrome?

Cited by 2 publications

References 15 publications

Irritable bowel syndrome: A comparison of subtypes

Irritable bowel syndrome: A comparison of subtypes

Potential Causes and Present Pharmacotherapy of Irritable Bowel Syndrome: An Overview

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