What is new about animal and human dirofilariosis?

Simón, F.; Morchón, Rodrigo; González‐Miguel, Javier; Marcos‐Atxutegi, C.; Siles-Lucas, Mar

doi:10.1016/j.pt.2009.06.003

Cited by 114 publications

(90 citation statements)

References 38 publications

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“…2,3 Heartworm disease is globally distributed, and is especially widespread in tropical and subtropical areas. 4 As a common amphixenosis, this disease is now receiving widespread attention, and increasing numbers of cases have been reported in recent years. [5][6][7][8][9] In some areas, disease is present in up to 30% of human serum samples.…”

Section: Introductionmentioning

confidence: 99%

Intraspecific Genetic Variation and Phylogenetic Analysis of Dirofilaria immitis Samples from Western China Using Complete ND1 and 16S rDNA Gene Sequences

Liang

Zhong

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Dirofilaria immitis (heartworm) is the causative agent of an important zoonotic disease that is spread by mosquitoes. In this study, molecular and phylogenetic characterization of D. immitis were performed based on complete ND1 and 16S rDNA gene sequences, which provided the foundation for more advanced molecular diagnosis, prevention, and control of heartworm diseases. The mutation rate and evolutionary divergence in adult heartworm samples from seven dogs in western China were analyzed to obtain information on genetic diversity and variability. Phylogenetic relationships were inferred using both maximum parsimony (MP) and Bayes methods based on the complete gene sequences. The results suggest that D. immitis formed an independent monophyletic group in which the 16S rDNA gene has mutated more rapidly than has ND1.

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Section: Introductionmentioning

confidence: 99%

Intraspecific Genetic Variation and Phylogenetic Analysis of Dirofilaria immitis Samples from Western China Using Complete ND1 and 16S rDNA Gene Sequences

Liang

Zhong

et al. 2014

The American Society of Tropical Medicine and Hygiene

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“…Human illnesses usually manifest as subcutaneous skin swelling (human subcutaneous dirofilariasis, HSD) or rarely, pulmonary dirofilariasis (human pulmonary dirofilariasis, HPD). The increase in the human dirofilarial infections are believed to be due to increase in mosquito density, warm climate that predisposes to extended mosquito breeding, increased human outdoor activities, close contact with dogs at home and abundance of microfilaraemia in stray dogs [1,2] .…”

Section: Discussionmentioning

confidence: 99%

Dirofilariasis: A Report on Emerging Zoonosis in South India

Augustine¹,

Narayanan²,

Tv³

et al. 2017

JCR

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Background: Dirofilaria is a filarial nematode worm transmitted by mosquitoes which rarely causes human infection. Case Report: A twelve year old girl who was otherwise asymptomatic, presented with a small swelling of around 1 cm diameter over the anterior chest wall. Ultrasonography showed a small cystic swelling with a linear echogenic structure in persistent twirling motion suggestive of a live worm. She underwent surgical removal of the swelling which showed two live Dirofilaria repens. Conclusion: Dirofilariasis should be considered as an emerging zoonosis of Kerala. Mosquito control is the best preventive strategy.

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“…Dirofilaria immitis is the causal agent of canine and feline cardiopulmonary dirofilariosis (heartworm disease) and of human pulmonary dirofilariosis, worldwide [1]. In animal reservoirs the disease, that afects pulmonary arteries, lungs and heart is serious and potentially fatal [2], while in humans which are accidental hosts, an iatrogenic damage can be produced after the fortuitous discovery of a benign pulmonary nodule that is frequently confused with lung cancer [3].…”

Section: Introductionmentioning

confidence: 99%

“…Cx. theileri has a wide distribution in the Old World [10], being present in many endemic areas of animal and human dirofilariosis, considering its current geographical distribution [1]. In Spain the presence of Cx.…”

Section: Introductionmentioning

confidence: 99%

Molecular Characterization of Culex Theileri from Canary Islands, Spain, a Potential Vector of Dirofilaria Immitis

Bargues¹

2013

J Clin Exp Pathol

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Dirofilaria immitis is the causal agent of heartworm diseases and of human pulmonary dirofilariosis. The infection is transmitted by several species of culicid mosquitoes that are frequently able to bite both animal reservoirs and humans. Canary Islands (Spain) constitute a well documented endemic area of canine dirofilariosis in which the mosquito species involved in the transmission of D. immitis are not known. The objectives of the present work were the identification of vectors of this parasite in Canary Islands and their molecular characterization. A total of 1219 female mosquitoes were captured. The most abundant species was Culex theileri (52.26%) followed by Cx. pipiens (35.44%), Anopheles cinereus hispaniola (6.23%), Culiseta longiareolata (5.74%), and Culex laticintus (0.33%). PCR was applied for the detection of larval D. immitis DNA in mosquitoes. D. immitis DNA was observed in the abdomen of one Cx. theileri female: 0.082% of the entire mosquito population and 0.17% in Cx. theileri. A molecular identification of Cx. theileri, the potential mosquito vector of dirofilariosis in this zoonotic focus in Canary Islands of Spain, has been made for first time based on sequences of the 18S rRNA gene, the second internal transcribed spacer (ITS2) of ribosomal DNA and the barcode region of the cytochrome c oxidase I (cox1) gene of mitochondrial DNA, allowing a broad mosquito molecular basis for future populations genetic analyses of this vector species. Parasitological and entomological molecular results suggest that Cx. theileri is a potential natural vector of D. immitis in Canary Islands.

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What is new about animal and human dirofilariosis?

Cited by 114 publications

References 38 publications

Intraspecific Genetic Variation and Phylogenetic Analysis of Dirofilaria immitis Samples from Western China Using Complete ND1 and 16S rDNA Gene Sequences

Intraspecific Genetic Variation and Phylogenetic Analysis of Dirofilaria immitis Samples from Western China Using Complete ND1 and 16S rDNA Gene Sequences

Dirofilariasis: A Report on Emerging Zoonosis in South India

Molecular Characterization of Culex Theileri from Canary Islands, Spain, a Potential Vector of Dirofilaria Immitis

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