What Is New in the Clinical Management of Low Back Pain: A Narrative Review

Orrillo, Enrique; Neira, Luis Vidal; Piedimonte, Fabián; Sánchez, Ricardo Plancarte; Mihovilovic, Smiljan Astudilllo; Tamayo, Marco Antonio Narvaez; Rekatsina, Martina; Varrassi, Giustino

doi:10.7759/cureus.22992

Cited by 6 publications

(5 citation statements)

References 78 publications

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“…Es ist wichtig, bei andauernden Schmerzen differentialdiagnostisch auch an eine osteoporotische Fraktur zu denken. Viel zu häufig erfolgt die Einleitung einer alleinigen Schmerztherapie ohne Abklärung einer Osteoporose [27]. Günstig ist zudem, dass viele Osteoporosetherapeutika auch einen zusätzlichen analgetischen Effekt haben, der genutzt werden sollte [29].…”

Section: Andauernder Schmerz Multimorbidität Und Sturzrisikounclassified

Einfluss von andauerndem Schmerz und Medikamenten auf das Sturz- und Frakturrisiko

Frohnhofen,

Stenmanns

2024

Osteologie

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ZusammenfassungDie Prävalenz von Schmerzen steigt mit dem Alter, ebenso wie die Anzahl der gleichzeitig vorliegenden Erkrankungen. Diese Multimorbidität triggert zudem die Verordnung zahlreicher Medikamente. Diese sog. Polypharmazie oder die Verordnung bestimmter Medikamentengruppen wie Analgetika, Hypnotika oder Antidepressiva sind mit der Häufigkeit von Sturzereignissen und Frakturen assoziiert. Diese Assoziation verleitet dazu, durch eine Reduktion der Anzahl der verordneten Medikamente ungünstige Ereignisse zu verhindern. Die Evidenz für diesen Ansatz konnte in randomisierten Studien jedoch nicht erbracht werden. Das Management der Medikation im Alter erfordert eine klare Indikation für ein Präparat, die regelmäßige Überprüfung dieser Indikation und die Auswahl des am besten verträglichen Präparates.

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Section: Andauernder Schmerz Multimorbidität Und Sturzrisikounclassified

Einfluss von andauerndem Schmerz und Medikamenten auf das Sturz- und Frakturrisiko

Frohnhofen,

Stenmanns

2024

Osteologie

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“…In terms of pain treatment, we can choose between over-thecounter nonsteroidal anti-inflammatory drugs (NSAIDs) and prescribed drugs. Back spasms can be treated with other medications that relax the muscles in the back (Major-Helsloot et al, 2014;Orrillo et al, 2022).…”

Section: Lbp Managementmentioning

confidence: 99%

An Overview on Low Back Pain and Functional Disability: Associated Risk Factors and Management

Abdelbasset

Sulieman

2022

Journal of Disability Research

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Recently, low back pain (LBP) has been a major contributor to disability worldwide. Chronic LBP affects 80% of the population at some point. The incidence of LBP is on the rise, especially among the elderly, and it is more common in men than in women. The different aspects of one’s life, such as a history of mental illness, being overweight, smoking, not getting enough exercise, getting older, and leading a sedentary lifestyle, all increase the likelihood of developing LBP. According to research, there are a number of causes and contributing factors that add up to a hefty price tag for disabled people. Functional disability in chronic LBP can be caused in part by causes other than the disease itself, such as psychological and professional variables, and can put restrictions on one’s personal life, work life, and family life. According to a recent study, more than 80% of those with a functional disability were classified as having a moderate-to-severe impairment. Therefore, we have proposed this review to clarify the appropriate assessment and interventional modalities for LBP and reduce disability. The diagnosis of LBP may need physical examination as well as imaging procedures to rule out the possibility of other ailments, such as broken bones. There is more than one technique to treat the underlying causes of LBP. Interventions include several modalities, including medication, physical therapy, manual therapy, injections, and surgery. In terms of pain treatment, we could choose between over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) and prescribed drugs. Back spasms can be treated with other medications that relax the muscles in the back. Physiotherapy can help an individual build up the core muscles that protect the spine. Physical therapy can help individuals to stay injury-free by doing more than just increasing the range of motion. Tense muscles can be relaxed, pain can be lessened, and posture and alignment can be enhanced through a series of sessions.

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“…In addition, low back pain can be associated with some diseases such as tumors and infections. Epidemiological studies show that low back pain affects about 80% of people in Western countries during their lifetime ( 2 ). In Europe, the prevalence of low back pain has ranged between 6 and 11% in the general population ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Dried fruit intake causally protects against low back pain: A Mendelian randomization study

Huang

Xie

2023

Front. Nutr.

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BackgroundLow back pain is the leading cause of years lived with disability worldwide. The aim of this study was to evaluate whether dried fruit intake causally protects against low back pain using two-sample Mendelian randomization (MR).MethodsWe obtained summary-level data for dried fruit intake (N = 421,764) from the IEU Open GWAS Project. Forty-one independent genetic variants proxied dried fruit intake. The corresponding data for low back pain were derived from the FinnGen project (13,178 cases and 164,682 controls; discovery data) and the Neale lab (5,423 cases and 355,771 controls; replication data). We conducted univariable and multivariable MR analyses.ResultsIn the univariable MR analysis, the inverse variance weighted estimate showed that greater dried fruit intake was associated with decreased risk of low back pain [odds ratio (OR) = 0.435, 95% confidence interval (CI): 0.287–0.659, P = 8.657 × 10−5]. Sensitivity analyses using the MR-Egger (OR = 0.078, 95% CI: 0.013–0.479, P = 0.009), maximum likelihood (OR = 0.433, 95% CI: 0.295–0.635, P = 1.801 × 10−5), weighted median (OR = 0.561, 95% CI: 0.325–0.967, P = 0.038) and Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) (OR = 0.454, 95% CI: 0.302–0.683, P = 4.535 × 10−4) methods showed consistent results. No evidence of directional pleiotropy was identified according to the Egger intercept (intercept P-value = 0.065) or applying the MR-PRESSO method (global test P-value = 0.164). The replication analysis yielded similar results. The multivariable MR revealed that the inverse association between dried fruit intake and low back pain was consistent after adjustment for fresh fruit intake, body mass index, current tobacco smoking, alcohol intake frequency, total body bone mineral density, serum 25-hydroxyvitamin D levels, and vigorous physical activity.ConclusionThis MR study provides evidence to support that dried fruit intake causally protects against low back pain.

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What Is New in the Clinical Management of Low Back Pain: A Narrative Review

Cited by 6 publications

References 78 publications

Einfluss von andauerndem Schmerz und Medikamenten auf das Sturz- und Frakturrisiko

Einfluss von andauerndem Schmerz und Medikamenten auf das Sturz- und Frakturrisiko

An Overview on Low Back Pain and Functional Disability: Associated Risk Factors and Management

Dried fruit intake causally protects against low back pain: A Mendelian randomization study

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