What Is New in the Prophylaxis and Treatment of Venous Thromboembolism?

Abstract

Deep venous thrombosis continues to be a frequent complication of surgery and trauma. The topic is controversial with regard to diagnosis, indication for prophylaxis, and suitable methods for prophylaxis and therapy. We review some of the highlights of the extensive literature in this field during the last few years. Particular emphasis is given to new trends in diagnostic methods, newly discovered genetic factors for thrombophilia, and the use of heparins for prophylaxis and therapy of thromboembolic disease.

In vivo analysis of antithrombotic effectiveness of recombinant hirudin on microvascular thrombus formation and recanalization

“…Despite improvements in technique and experience gained in clinical microvascular surgery, small vessel thrombosis after operative procedures remains a considerable uncertainty in vascular and reconstructive surgery, even in the hands of the most technically experienced physicians. [1][2][3][4] To prevent the manifestation of thrombosis, a variety of anticoagulation and antiplatelet aggregation agents have been introduced into clinical practice, [5][6][7] but a definitive choice for the most effective prophylaxis has not yet been determined.…”