What is the Best Treatment for a Cancer Patient with Thrombosis?

Barbosa, Miguel

doi:10.4137/cmo.s13386

Cited by 14 publications

(10 citation statements)

References 49 publications

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“…However, it is known that the disaccharide constituents and chain lengths of GAGs are critical to their property and biological functions [15, 17, 18]; for example, 4S6S CS-E is a potent antiviral agent [32], HA with high molecular weight demonstrates antiangiogenic activity effect [33] while low molecular weight HA fragments can stimulate angiogenesis [34], heparins are anticoagulants with low molecular weight heparins having higher anti-FXa activity and lower incidence of side effects [12]. Therefore, the properties and biological activities of GAGs in the egg components need further elucidation.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to being used as an emulsifying agent in condiments and mayonnaise [8], CS has nutraceutical and pharmaceutical applications in arthritis herpes virus infection, malaria, nervous tissue repair, liver regeneration, and for tumors [9]. Heparin, a highly sulfated HS, has potent functions in allergy, inflammation [10] and anticoagulation [11], and has a long history of being used as anticoagulants in advanced medical and surgical procedures [12]. Finally, KS plays a fundamental role in ocular inflammation, corneal injury, keratitis, and uveitis [13].…”

Section: Introductionmentioning

confidence: 99%

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Compositional analysis and structural elucidation of glycosaminoglycans in chicken eggs

Liu

Zhang

et al. 2014

Glycoconj J

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Glycosaminoglycans (GAGs) have numerous applications in the fields of pharmaceuticals, cosmetics, nutraceuticals, and foods. GAGs are also critically important in the developmental biology of all multicellular animals. GAGs were isolated from chicken egg components including yolk, thick egg white, thin egg white, membrane, calcified shell matrix supernatant, and shell matrix deposit. Disaccharide compositional analysis was performed using ultra high-performance liquid chromatography-mass spectrometry. The results of these analyses showed that all four families of GAGs were detected in all egg components. Keratan sulfate was found in egg whites (thick and thin) and shell matrix (calcified shell matrix supernatant and deposit) with high level. Chondroitin sulfates were much more plentiful in both shell matrix components and membrane. Hyaluronan was plentiful in both shell matrix components and membrane, but were only present in a trace of quantities in the yolk. Heparan sulfate was plentiful in the shell matrix deposit but was present in a trace of quantities in the egg content components (yolk, thick and thin egg whites). Most of the chondroitin and heparan sulfate disaccharides were present in the GAGs found in chicken eggs with the exception of chondroitin and heparan sulfate 2,6-disulfated disaccharides. Both CS and HS in the shell matrix deposit contained the most diverse chondroitin and heparan sulfate disaccharide compositions. Eggs might provide a potential new source of GAGs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Compositional analysis and structural elucidation of glycosaminoglycans in chicken eggs

Liu

Zhang

et al. 2014

Glycoconj J

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“… 87 Unlike LMWHs and warfarin, which inhibit multiple coagulation factors, NOACs target specific clotting cascade factors; NOACs are more attractive to patients and clinicians because they do not require laboratory monitoring to achieve therapeutic anticoagulation, they can be taken orally in fixed doses once or twice daily, and they have minimal food and drug–drug interactions. 41 , 54 , 88 The major limitation is the lack of specific antidotes to reverse the anticoagulant effect and the absence of readily available assays to measure the anticoagulant effect, which can be an issue when facing bleeding events or treatment failure. 55 , 87 To date, NOACs have not been rigorously evaluated in cancer patients.…”

Section: Novel Oral Anticoagulantsmentioning

confidence: 99%

Cancer-Associated Thrombosis: An Overview

Elyamany

AlZahrani

Bukhary

2014

Clin Med Insights Oncol

180

155

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Venous thromboembolism (VTE) is a common complication in patients with malignant disease. Emerging data have enhanced our understanding of cancer-associated thrombosis, a major cause of morbidity and mortality in patients with cancer. In addition to VTE, arterial occlusion with stroke and anginal symptoms is relatively common among cancer patients, and is possibly related to genetic predisposition. Several risk factors for developing venous thrombosis usually coexist in cancer patients including surgery, hospital admissions and immobilization, the presence of an indwelling central catheter, chemotherapy, use of erythropoiesis-stimulating agents (ESAs) and new molecular-targeted therapies such as antiangiogenic agents. Effective prophylaxis and treatment of VTE reduced morbidity and mortality, and improved quality of life. Low-molecular-weight heparin (LMWH) is preferred as an effective and safe means for prophylaxis and treatment of VTE. It has largely replaced unfractionated heparin (UFH) and vitamin K antagonists (VKAs). Recently, the development of novel oral anticoagulants (NOACs) that directly inhibit factor Xa or thrombin is a milestone achievement in the prevention and treatment of VTE. This review will focus on the epidemiology and pathophysiology of cancer-associated thrombosis, risk factors, and new predictive biomarkers for VTE as well as discuss novel prevention and management regimens of VTE in cancer according to published guidelines.

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“…A variety of diseases such as atherosclerosis, tumor, diabetes, and kidney syndrome are associated with the hypercoagulable state (Piatek et al, 2012;Geddings and Mackman, 2013;Youngwon et al, 2013;Barbosa, 2014;Elyamany et al, 2014;Ahluwalia and Sreedharanunni, 2016). It is generally believed that the occurrence of the hypercoagulable state is due to the coagulation dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Proteome Analysis of Urinary Biomarkers in Acute Hypercoagulable State Rat Model

Jing

Qin

2021

Front. Mol. Biosci.

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Thrombotic diseases are usually preceded by a hypercoagulable state in the body. This study aimed to screen potential urinary biomarkers for hypercoagulable state based on proteome analysis. Wistar rats were administered with the hemostatic agent etamsylate to establish hypercoagulable state. Urine samples were collected for proteome analysis. We found 20 proteins with levels more than 1.5-fold in difference between control rats and model rats. We searched human homologs of 20 rat proteins and identified 13 human proteins. Of the 13 human homologous proteins, nine were members of human core urinary proteome. Human homologous proteins of differential proteins were highly expressed in 31 human tissues, especially in the kidneys followed by digestive system and reproductive system. Surprisingly, we did not identify known coagulation factors as differential proteins in the urine of model rats. Hypercoagulable state of the body may not involve direct changes in coagulation factors but causes the changes upstream of the coagulation cascade system. Common differential urinary proteins between different hypercoagulable states suggest some common pathways in the formation of hypercoagulable states and may serve as potential biomarkers for the prevention and treatment of thrombotic diseases.

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What is the Best Treatment for a Cancer Patient with Thrombosis?

Cited by 14 publications

References 49 publications

Compositional analysis and structural elucidation of glycosaminoglycans in chicken eggs

Compositional analysis and structural elucidation of glycosaminoglycans in chicken eggs

Cancer-Associated Thrombosis: An Overview

Proteome Analysis of Urinary Biomarkers in Acute Hypercoagulable State Rat Model

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