What is the clinical usefulness of the metabolic syndrome? The Casale Monferrato study

Bruno, Graziella; Fornengo, Paolo; Segre, Olivia; Novelli, Giulia; Panero, Francesco; Perotto, Massimo; Zucco, Chiara; Bargero, G; Cavallo‐Perin, P.

doi:10.1097/hjh.0b013e3283310ee5

Cited by 10 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whether the cardiometabolic risk factors that constitute the metabolic syndrome occur alone or in clusters, evidence indicates that all such risk factors should be addressed individually, and managed effectively (27). To our knowledge, no evidence has been put forward to date for nonadditivity of these metabolic factors on the risk of type 2 diabetes, incident cardiovascular disease, or mortality (i.e., that the risk associated with the metabolic syndrome exceeds the risk conferred by the sum of the individual cardiometabolic risk factors that contributes to the syndrome) (27–29). …”

Section: Discussionmentioning

confidence: 99%

Prevalence of Metabolic Syndrome Among Hispanics/Latinos of Diverse Background: The Hispanic Community Health Study/Study of Latinos

et al. 2014

View full text Add to dashboard Cite

OBJECTIVEApproximately one-third of the adult U.S. population has the metabolic syndrome. Its prevalence is the highest among Hispanic adults, but variation by Hispanic/Latino background is unknown. Our objective was to quantify the prevalence of the metabolic syndrome among men and women 18–74 years of age of diverse Hispanic/Latino background.RESEARCH DESIGN AND METHODSTwo-stage area probability sample of households in four U.S. locales, yielding 16,319 adults (52% women) who self-identified as Cuban, Dominican, Mexican, Puerto Rican, Central American, or South American. The metabolic syndrome was defined according to the American Heart Association/National Heart, Lung, and Blood Institute 2009 Joint Scientific Statement. The main outcome measures were age-standardized prevalence of the metabolic syndrome per the harmonized American Heart Association/National Heart, Lung, and Blood Institute definition and its component abnormalities.RESULTSThe metabolic syndrome was present in 36% of women and 34% of men. Differences in the age-standardized prevalence were seen by age, sex, and Hispanic/Latino background. The prevalence of the metabolic syndrome among those 18–44, 45–64, and 65–74 years of age was 23%, 50%, and 62%, respectively, among women; and 25%, 43%, and 55%, respectively, among men. Among women, the metabolic syndrome prevalence ranged from 27% in South Americans to 41% in Puerto Ricans. Among men, prevalences ranged from 27% in South Americans to 35% in Cubans. In those with the metabolic syndrome, abdominal obesity was present in 96% of the women compared with 73% of the men; more men (73%) than women (62%) had hyperglycemia.CONCLUSIONSThe burden of cardiometabolic abnormalities is high in Hispanic/Latinos but varies by age, sex, and Hispanic/Latino background. Hispanics/Latinos are thus at increased, but modifiable, predicted lifetime risk of diabetes and its cardiovascular sequelae.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of Metabolic Syndrome Among Hispanics/Latinos of Diverse Background: The Hispanic Community Health Study/Study of Latinos

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Of the publications found, only one publication was about the incidence of MVS [11], 50 articles were about the prevalence , 13 examined the co-ocurrence with type 2 diabetes (T2DM), and 29 the coexistence of the MVS with cardiovascular diseases (CVD) [14,19,20,23,24,29,30,33,34,38,39,42,43,45,57,63,64,[66][67][68][69][70][71][72][73][74][75][76][77]. There was no study about the natural history of the MVS.…”

Section: Selection Processmentioning

confidence: 99%

Systematic Review of the Epidemiology and Natural History of the Metabolic Vascular Syndrome and its Coincidence with Type 2 Diabetes Mellitus and Cardiovascular Diseases in Different European Countries

et al. 2017

View full text Add to dashboard Cite

The objectives of this systematic review were to estimate the incidence, prevalence and natural history of the metabolic (vascular) syndrome (MVS) among adults in different European countries. Furthermore, we assessed its co-incidence with type 2 diabetes (T2DM) and cardiovascular diseases (CVD). PubMed, MedLine, and EMBASE (via Ovid) were searched for relevant studies. After reading 116 full-text articles to find eligible ones, 66 publications met our inclusion criteria. Data for the incidence are based on a study from Portugal, in which the incidence rate for the MVS was 47.2/1000 person-years. Prevalence varied strongly depending on country and definition. The lowest was found in the United Kingdom (3%), the highest in Finland (71.7%). No article that deals with the natural history of the MVS was found. Considering the co-existence of MVS and T2DM, it ranged between 2% (United Kingdom) and 74.4% (Spain). The co-occurrence of MVS and CVD ranged from 2.8% (Italy) up to 52% (Netherlands). Coronary heart disease (CHD) varied between 1.2% and 44.2%. With regard to peripheral artery disease (PAD), values between 3.3% and 59.8% were found. Due to the many different definitions of the MVS, a comparison is very difficult. Overall prevalence ranged between 3% and 71.7% depending on definition, age, and country. An association between MVS and T2DM as well as several CVD can be assumed.

show abstract

“…[32] Higher OR (4.37, CI: 3.25–5.87) of CVD in individuals with both MetS and DM was shown from another Mediterranean cohort. [33] Nevertheless, this study failed to show an independent association of MetS with CVD in patients with or without DM, after further adjustment for its individual components, arguing against of an additional information provided by diagnosing MetS. [33] In both Mediterranean men and women a significant association of MetS with stroke (OR = 1.67, 95% CI: 1.02–2.75 in men and OR = 1.72, CI: 1.01–2.93 in women) and DM (OR = 4.58, CI, 3.12–6.74 in men and OR = 5.15, CI: 3.23–8.20 in women) has been reported.…”

Section: Clinical Significancementioning

confidence: 99%

Metabolic syndrome in the Mediterranean region: Current status

Anagnostis¹

2012

Indian J Endocr Metab

View full text Add to dashboard Cite

Metabolic syndrome (MetS) is a cluster of metabolic abnormalities including abdominal obesity, impaired fasting glucose, hypertension and dyslipidemia. It seems to affect about one-fourth to one-fifth of the Mediterranean population, and its prevalence increases with age, being similar for both sexes and depending on the region and the definition used, with the National Cholesterol Education Program-Adult Treatment Panel-III (NCEP-ATPIII) definition being the most effective in the identification of glucose intolerance and cardiovascular risk. Except for these, MetS is associated with fatty liver disease, some forms of cancer, hypogonadism, and vascular dementia. The Mediterranean diet seems to be an ideal diet in patients with MetS, being rich in fibre, monounsaturated and polyunsaturated fats, and low in animal protein; and decreases the prevalence of MetS and cardiovascular disease risk. Except for weight loss, multifactorial intervention including insulin resistance reduction and normoglycemia, management of dyslipidemia, optimizing blood pressure and administration of low-dose aspirin for patients at high or moderately high cardiovascular disease (CVD) risk are additional targets. The present review provides current understanding about MetS in the Mediterranean region, focusing on its prevalence, clinical significance, and therapeutic strategy.

show abstract

What is the clinical usefulness of the metabolic syndrome? The Casale Monferrato study

Abstract: The additional information provided by the metabolic syndrome is limited, in both diabetic and nondiabetic people, whereas the HOMA index is a useful indicator of CVD, independently of individual components of the metabolic syndrome, classical and novel risk factors.

Cited by 10 publications

References 24 publications

Prevalence of Metabolic Syndrome Among Hispanics/Latinos of Diverse Background: The Hispanic Community Health Study/Study of Latinos

Prevalence of Metabolic Syndrome Among Hispanics/Latinos of Diverse Background: The Hispanic Community Health Study/Study of Latinos

Systematic Review of the Epidemiology and Natural History of the Metabolic Vascular Syndrome and its Coincidence with Type 2 Diabetes Mellitus and Cardiovascular Diseases in Different European Countries

Metabolic syndrome in the Mediterranean region: Current status

Contact Info

Product

Resources

About