What is the difference between the tall cell variant and the classic type of papillary thyroid carcinoma on ultrasonography?

Kim, Hae Jung; Oh, Young Lyun; Chung, Jae Hoon; Hahn, Soo Yeon; Park, Ko Woon; Kim, Tae Hyuk; Shin, Jung Hee

doi:10.14366/usg.21200

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…To the best of our knowledge, few studies evaluated the ability of preoperative FNAC to identify PTC subtypes [ 19 – 22 ]. Similarly, only emerging studies describing the US image characteristics of PTC subtypes have been published to date [ 16 , 23 – 27 ].…”

Section: Introductionmentioning

confidence: 99%

Prediction of classical versus non classical papillary thyroid carcinoma subtypes from cytology of nodules classified according to TIRADS

Scappaticcio,

Trimboli,

Bellastella

et al. 2023

Endocrine

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Purpose Our purposes were: 1) to estimate the prediction performance (PP) of cytology in identifying papillary thyroid carcinoma (PTC) subtypes; 2) to explore how the PTC subtypes distribute among the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) categories. Methods Nodules were included if both the histology with the PTC subtype report and the cytology report with the possible PTC subtype were available. The PP was calculated by making the proportion of True positives/False positives+false negatives. Results 309 cytologically “suspicious for malignancy” and “malignant” thyroid nodules with PTC histology were evaluated. ACR TI-RADS categorization for classical PTC was significantly different from non-classical PTC (p-value 0.02). For the whole cohort the PP of cytologically classical cases was 0.74, while that of cytologically non classical cases was 0.41. ACR TI-RADS categorization was not significantly different for aggressive vs non-aggressive PTC subtypes (p-value 0.1). When considering only aggressive or non-aggressive PTC subtypes, the PP of cytologically classical cases was respectively 0.86 and 0.87, while that of cytologically non classical cases was respectively 0.27 and 0.22. The PP of cytologically classical cases was 0.73 and 0.79, respectively for macroPTCs and microPTCs, while that of cytologically non classical cases was 0.55 and 0.33, respectively for macroPTCs and microPTCs. Conclusion Cytology examination reliably performed in predicting classical PTC versus non classical PTC subtypes. ACR TI-RADS categorization was significantly different among classical PTC versus non classical PTC subtypes.

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Section: Introductionmentioning

confidence: 99%

Prediction of classical versus non classical papillary thyroid carcinoma subtypes from cytology of nodules classified according to TIRADS

Scappaticcio,

Trimboli,

Bellastella

et al. 2023

Endocrine

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Tall Cell Subtype of Papillary Thyroid Carcinoma

Chen

2023

Thyroid FNA Cytology

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Predicting tall-cell subtype of papillary thyroid carcinomas independently with preoperative multimodal ultrasound

Ye,

Liu,

Zhang

et al. 2024

British Journal of Radiology

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Objectives This study aimed to explore the differences between tall-cell subtype of papillary thyroid carcinoma (TCPTC) and classical papillary thyroid carcinoma (cPTC) using multimodal ultrasound, and identify independent risk factors for TCPTC to compensate the deficiency of preoperative cytological and molecular diagnosis on PTC subtypes. Methods 46 TCPTC patients and 92 cPTC patients were included. Each patient received grey-scale ultrasound, color Dopplor flow imaging (CDFI) and shear-wave elastography (SWE) preoperatively. Clinicopathologic information, grey-scale ultrasound features, CDFI features and SWE features of 98 lesion were compared using univariate analysis to find out predictors of TCPTC, based on which, a predictive model was built to differentiate TCPTC from cPTC and validated with 40 patients. Results Univariate and multivariate analysis identified that extrathyroidal extension (OR, 15.12; 95% CI, 2.26-115.44), aspect ratio (≥0.91) (OR, 29.34; 95% CI, 1.29-26.23), and maximum diameter ≥ 14.6 mm (OR, 20.79; 95% CI, 3.87-111.47) were the independent risk factors for TCPTC. Logistic regression equation: p = 1/1+ExpΣ[-5.099 + 3.004 × (if size ≥14.6 mm)+2.957 × (if aspect ratio≥0.91)+2.819 × (if extra-thyroidal extension)]. The prediction model had a good discrimination performance for TCPTC: the AUC, sensitivity and specificity were 0.928, 0.848 and 0.954 in cohort 1, and the corresponding values in cohort 2 were 0.943, 0.923 and 0.926. Conclusion Ultrasound has potential for differential diagnosis of TCPTC from cPTC. A prediction model based on ultrasound characteristics (extrathyroidal extension, aspect ratio ≥0.91, and maximum diameter ≥14.6 mm) was useful to predict TCPTC. Advances in knowledge Multimodal ultrasound prediction of TCPTC were supplements to preoperative cytological diagnosis and molecular diagnosis on PTC subtypes.

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What is the difference between the tall cell variant and the classic type of papillary thyroid carcinoma on ultrasonography?

Cited by 4 publications

References 31 publications

Prediction of classical versus non classical papillary thyroid carcinoma subtypes from cytology of nodules classified according to TIRADS

Prediction of classical versus non classical papillary thyroid carcinoma subtypes from cytology of nodules classified according to TIRADS

Tall Cell Subtype of Papillary Thyroid Carcinoma

Predicting tall-cell subtype of papillary thyroid carcinomas independently with preoperative multimodal ultrasound

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