2020
DOI: 10.3390/jcm9092988
|View full text |Cite
|
Sign up to set email alerts
|

What Is the Ideal Blood Pressure Threshold for the Prevention of Atrial Fibrillation in Elderly General Population?

Abstract: Intensive blood pressure (BP) lowering in patients with hypertension at increased risk of cardiovascular disease has been associated with a lowered risk of incident atrial fibrillation (AF). It is uncertain whether maintaining the optimal BP levels can prevent AF in the general elderly population. We included 115,866 participants without AF in the Korea National Health Insurance Service-Senior (≥60 years) cohort from 2002 to 2013. We compared the influence of BP on the occurrence of new-onset AF between octoge… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
4
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
5

Relationship

1
4

Authors

Journals

citations
Cited by 5 publications
(4 citation statements)
references
References 28 publications
(38 reference statements)
0
4
0
Order By: Relevance
“…To date, BP is related to the risk of incident AF by a U-shaped relation, in which the lowest risk for new AF may be obtained through BP levels <130/80 mmHg in patients under 80 compared to less severe thresholds in those aged >80. 88 Being an end-product of the hypertensive state, left ventricular (LV) hypertrophy (LVH) has also been identified as a predictor of new AF in many registries. 89 Although the prevalence of LVH in the hypertensive population broadly varies among studies according to different diagnostic criteria adopted, AF prevalence seems to be higher in patients with more severe ventricular remodelling (especially in the case of concentric and eccentric hypertrophy).…”
Section: Af and Comorbidities: Clinical Implications And Translational Perspectivesmentioning
confidence: 99%
“…To date, BP is related to the risk of incident AF by a U-shaped relation, in which the lowest risk for new AF may be obtained through BP levels <130/80 mmHg in patients under 80 compared to less severe thresholds in those aged >80. 88 Being an end-product of the hypertensive state, left ventricular (LV) hypertrophy (LVH) has also been identified as a predictor of new AF in many registries. 89 Although the prevalence of LVH in the hypertensive population broadly varies among studies according to different diagnostic criteria adopted, AF prevalence seems to be higher in patients with more severe ventricular remodelling (especially in the case of concentric and eccentric hypertrophy).…”
Section: Af and Comorbidities: Clinical Implications And Translational Perspectivesmentioning
confidence: 99%
“…Hypertension is the most common risk factor of incident atrial fibrillation [ 8 , 19 ], and increased blood pressure is associated with a greater burden of atrial fibrillation [ 5 , 6 ]. Atrial fibrillation is not only related with impaired quality of life because of more hospitalizations and cognitive impairment but also is associated with a substantial risk of mortality and morbidity resulting from stroke and congestive heart failure [ 1 , 3 , 13 ].…”
Section: Discussionmentioning
confidence: 99%
“…Hypertension is highly prevalent in populations with atrial fibrillation and provides the highest attributable risk for the development of atrial fibrillation [ 4 ]. Patients with poorly controlled blood pressure (BP) have an associated increased risk of incident atrial fibrillation [ 5 , 6 ] and the development of adverse cardiovascular outcomes [ 7 ]. However, hypertension rarely occurs as an isolated disorder and is often accompanied by a number of comorbidities that are indicative of signs of target organ damage because of elevated BP [ 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, apart from the pulmonary vein triggers that have been extensively studied [4], the relationship between other triggers (inflammation as in acute AF [5][6][7], stable coronary artery disease [8], or post-operative AF [9]), the modulator (mainly autonomic nervous system dysregulation [10]) and substrate alterations (fibrosis but also changes in the conduction properties of the atrial cells even in the absence of a quantifiable "scar" [11]) have been recently brought to light by several papers [12,13]. The interplay between cardiovascular risk factors, mainly high blood pressure [14] and obesity [6], atrial epicardial fat, and atrial ganglionated plexi [15], is complex and critical for the understanding of AF, but also in the search for new treatments. In this regard, a particular focus should be placed on the new anti-diabetic therapies (SGLT-2 inhibitors [16] and GLP-1 receptor agonists [17]) that have not only proven a benefit for major cardiovascular events (MACE) occurrence but also a decrease in AF burden.…”
mentioning
confidence: 99%