What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group – EWING1

Becker, Ricardo Gehrke; Gregianin, Lauro José; Gália, Carlos Roberto; Filho, Reynaldo Jesus Garcia; Toller, Eduardo Areas; Badell, Gerardo; Nakagawa, Suely Akiko; David, Alexandre; Baptista, André Mathias; Yonamime, Eduardo S.; Serafini, Osvaldo André; Penna, Valter; Santos, Julie Francine Cerutti; Brunetto, Algemir Lunardi

doi:10.1186/s12885-017-3391-5

Cited by 23 publications

(19 citation statements)

References 33 publications

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“…The effect of radiation therapy on the prognosis for metastatic ES is unclear. Previous studies have shown that patients with ES who received only radiation therapy as the local treatment, had significantly reduced OS and CSS compared with patients who underwent surgery alone [24,29,30], which is consistent with the findings of the present study. However, some studies have reported that radiation therapy alone improved local control and survival that was comparable to surgery [31–33].…”

Section: Discussionsupporting

confidence: 93%

Surgical Resection of Primary Ewing’s Sarcoma of Bone Improves Overall Survival in Patients Presenting with Metastasis

et al. 2019

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Background Metastatic Ewing’s sarcoma (ES) of bone has a poor prognosis. Because there have been few previous studies on the prognostic factors and clinical outcome in patients with ES who have metastases at presentation, the aim of this study was to use the Surveillance, Epidemiology, and End Results (SEER) database to compare the clinical outcome following single and combined radiation treatment and surgery. Material/Methods The SEER database was used to identify patients with ES who presented with bone involvement and metastasis between 1973 to 2015. Prognostic analysis was performed using the Kaplan-Meier method and the Cox proportional hazards regression model. Results There were 643 patients identified from the SEER database. The 5-year overall survival (OS) and cancer-specific survival (CSS) rates were 33.1% and 34.3%, respectively and the median OS and CSS were 29.0±1.9 and 29.0±2.1 months, respectively. Multivariate analysis identified age <20 years and surgical resection of the primary tumor to be significantly associated with improved OS. Radiation therapy was not an independent predictor of OS or CSS. Radiation therapy alone resulted in a significantly reduced the OS and CSS compared with surgical resection alone. Combined surgery and radiation therapy of the primary tumor did not significantly improve the OS or CSS of patients with ES and metastatic disease when compared with surgery alone. Conclusions Age <20 years and surgical resection of the primary tumor were significantly associated with improved OS in patients with primary ES of bone who presented with metastasis.

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Section: Discussionsupporting

confidence: 93%

Surgical Resection of Primary Ewing’s Sarcoma of Bone Improves Overall Survival in Patients Presenting with Metastasis

et al. 2019

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“…In this study; site of the tumor had no significant effect and this was contrary to Karski EE et al also no significant impact of surgery on LRFS which wasn't comparable to Ricardo G et al [11] that detected a 5-year event free survival of 30.8% for patients received definitive RT, 64.1% for surgery plus RT and 71.7% for surgery alone. 3-year LC in our study was 35% which was comparable to DuBois SG [1] that denoted high incidence of local relapses in those received definitive RT and in ours; the local control was low as no complete surgical excision was done.…”

Section: Discussioncontrasting

confidence: 95%

Accelerated Hyper Fractionated Radiotherapy in Localized Ewing’s Sarcoma with or without Surgery: What’s New? A Phase II Study

Rayan¹,

Soliman²,

Riad³

et al. 2018

JCT

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Background and aim of work: We aimed from this study to determine the response and local relapse free survival (RFS) of pediatric patients with localized Ewing's sarcoma treated with accelerated hyper-fractionated RT. Patient and methods: This study was a nonrandomized uncontrolled phase II study and was conducted at clinical oncology department and south Egypt cancer institute; it involved 28 patients with histologically confirmed Ewing's sarcoma; all of them were subjected to PET/CT whenever possible or MRI with contrast of the primary site, MSCT chest, bone scan, and LDH to ensure absence of metastasis followed by the protocol of accelerated hyper fractionated RT. Results: The overall response rate (ORR) was 92.9% by MRI with significant effect of the type of response on local RFS (P < 0.002). The median local RFS of 28 patients with localized Ewing's sarcoma was 30 ± 8.599 months with 95% CI = 13.147-46.853; the 3-year local control was 35%. Conclusion: Accelerated hyper fractionated RT didn't achieve better results than standard fractionation RT, but it is recommended to be done on a large sample size, and multiple centers, and continued follow up is also recommended to evaluate 5-year LRFS, 5-year OS.

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“…Small round cell tumors such as Ewing's sarcoma family usually respond well to radiation 24 . Therefore, radiotherapy is frequently indicated for primary and adjuvant treatment of PNET.…”

Section: Discussionmentioning

confidence: 99%

“…Until now, there have been no randomized studies comparing surgery and radiotherapy in Ewing tumors. Some studies reported that radical radiotherapy as the only local treatment for Ewing's sarcoma predicted adverse survival or local control 24,27,28 . However, in these studies, the choice of local treatment was influenced by multiple factors and thus non-randomized.…”

Section: Discussionmentioning

confidence: 99%

Outcome of multidisciplinary treatment of peripheral primitive neuroectodermal tumor

Liu

Yuan

Zhang

et al. 2020

Sci Rep

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Peripheral primitive neuroectodermal tumors (PNETs) constitute very rare and aggressive malignancies. To date, there are no standard guidelines for management of peripheral PNETs due to the paucity of cases arising in various body sites. Therapeutic approach is derived from Ewing sarcoma family, which currently remains multimodal. Our study retrospectively analyzed 86 PNET patients from February 1, 1998 to February 1, 2018 at Peking Union Medical College Hospital with an additional 75 patients from review of literature. The clinicopathologic and treatment plans associated with survival was investigated. Surgery, chemotherapy, female sex, small tumor size, no lymph node metastasis, R0 surgical resection, (vincristine + doxorubicin + cyclophosphamide)/(isophosphamide + etoposide) regimen, and more than 10 cycles of chemotherapy were associated with improved overall survival in univariate analysis. Surgery, more than 10 cycles of chemotherapy, and small tumor size were independent prognostic factors for higher overall survival. Our data indicates that multimodal therapy is the mainstay therapeutic approach for peripheral PNET.

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What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group – EWING1

Cited by 23 publications

References 33 publications

Surgical Resection of Primary Ewing’s Sarcoma of Bone Improves Overall Survival in Patients Presenting with Metastasis

Surgical Resection of Primary Ewing’s Sarcoma of Bone Improves Overall Survival in Patients Presenting with Metastasis

Accelerated Hyper Fractionated Radiotherapy in Localized Ewing’s Sarcoma with or without Surgery: What’s New? A Phase II Study

Outcome of multidisciplinary treatment of peripheral primitive neuroectodermal tumor

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