What is the impact of intravitreal injection of conbercept on neovascular glaucoma patients: a prospective, interventional case series study

Abstract

Background: The aim of the present study was to evaluate the efficacy and safety of intravitreal conbercept combined with trabeculectomy and panretinal photocoagulation for neovascular glaucoma (NVG). Methods: Fifty patients (54 eyes) with NVG were included in this prospective study. Fifty-two eyes initially underwent intravitreal conbercept, and then trabeculectomy and panretinal photocoagulation were performed. Preoperative and postoperative best-corrected visual acuity (BCVA), intraocular pressure (IOP), number of antiglaucoma medications, and surgical complications were recorded. The levels of VEGF-A, TGF-β1 and PLGF in aqueous humour that were collected during surgery were measured by enzyme-linked immunoabsorbent assay (ELISA). Light microscopy and transmission electron microscopy were used to observe the surgically excised trabecular tissue; enucleation was performed for 2 eyes, and light microscopy was used as the histopathological control. Results: At the last follow-up visit, mean IOP was reduced from 48.1±14.2 mmHg to 23.2±8.7 mmHg, and the mean number of antiglaucoma medications used decreased from 3.0 (3.0, 4.0) to 1.0 (0.0, 1.0) (both P < 0.05). After patients underwent intravitreal injection, the concentrations of VEGF-A and TGF-β1 in aqueous humour in NVG patients decreased from 168.8±13.4 pg/ml and 159.6±15.4 pg/ml to 160.2±7.6 pg/ml and 151.9±2.3 pg/ml, respectively (both P < 0.05). Light microscopy revealed neovascularization regression in the iris in specimens with intravitreal conbercept. Electron microscopy revealed endothelial cell degeneration in the conbercept-treated specimens. Conclusions: Our initial findings suggest that intravitreal conbercept is an effective treatment for managing neovascular glaucoma, with fewer postoperative complications in the short-term. Trial registration: Current Controlled Trials ChiCTR1800019918, 8 December 2018, Retrospectively registered. Keywords: Neovascular glaucoma; conbercept; anti-vascular endothelial growth factor; trabeculectomy

Effect of taspine hydrochloride on KGF signal pathway in skin wound healing in rats

“…Some studies have demonstrated that TGF-β1 and VEGF are key regulators of wound angiogenesis. For instance, GF-β1 binds to VEGF receptor and finally regulates neovascularization [22]. Decreased expressions and functions of TGF-β1 and VEGF may hinder wound healing [23].…”