What is the impact of gestational diabetes mellitus on frequency of structural chromosome aberrations in pregnant women and their offspring?

Witczak, Monika; Wilczyński, J; Gulczyńska, Ewa; Talar, Tomasz; Mordalska, Anna; Łopaczyńska, Dobrosława; Ferenc, Tomasz

doi:10.1016/j.mrgentox.2017.04.003

Cited by 10 publications

(6 citation statements)

References 29 publications

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“…It is associated with increased levels of oxidative stress due to overproduction of reactive oxygen species (ROS). The overproduction of ROS induces protein oxidation, lipid peroxidation and various types of DNA damage” [ 54 ]. However, it can be assumed that the currently established follow-up and treatments for GDM reduce the consequences on DNA.…”

Section: Discussionmentioning

confidence: 99%

Is Gestational Diabetes Mellitus a Risk Factor of Maternal Breast Cancer? A Systematic Review of the Literature

et al. 2021

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The association between gestational diabetes mellitus (GDM) and breast cancer (BC) risk is complex. We aimed to examine this association in a systematic review of the literature. This review was done using the PubMed/Medline and Web of Science databases, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Newcastle–Ottawa Scale was used for the assessment of bias and quality of studies. Only English-language articles published before 1 June 2021, were included. Fourteen studies were included in this systematic review. Among them, eight did not find statistically significant results. Three studies showed a statistically significant increased risk of BC after GDM, and they explained this potential increased risk by hyperinsulinemia, hyperglycemia, and low-grade inflammation. However, three studies showed a statistically significant decreased risk of BC after GDM, suggesting a possible protective effect of hormonal changes induced by GDM during pregnancy. These controversial results should be interpreted with caution due to both quantitative and qualitative methodological shortcomings. Further investigations are thus needed in order to gain a better understanding of the associations between GDM and BC, and their underlying mechanisms.

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Section: Discussionmentioning

confidence: 99%

Is Gestational Diabetes Mellitus a Risk Factor of Maternal Breast Cancer? A Systematic Review of the Literature

et al. 2021

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“…Hyperglycemia can cause increased generation of Reactive Oxygen Species (ROS). Overproduction of ROS induces protein oxidation, lipid peroxidation and different types of DNA damage [ 19 ].…”

Section: Clinical Presentationmentioning

confidence: 99%

Infant of a diabetic mother: clinical presentation, diagnosis and treatment

Suda-Całus,

Dąbrowska,

Gulczyńska

2024

pedm

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An infant of a diabetic mother is defined as a newborn born to a mother who has diabetes during pregnancy. The term diabetic mother refers to pregnant women with diabetes diagnosed either before (type 1 or 2 diabetes) or during pregnancy (gestational diabetes). Rising incidence of type 1 and type 2 diabetes in young women and increasing maternal age at conception account for the higher risk of birth complications and adverse maternal and infant outcomes. Infants of diabetic mothers (IDMs) because of mother's diabetes are prone to developing complications and the most common include: large birth weight and complications resulting from it (i.e. birth injuries, perinatal asphyxia), cardiovascular and respiratory insufficiency (poor tolerance of labor stress), neonatal hypoglycemia and it's complications, delayed lung maturity (fetal hyperinsulinism and the opposite function of insulin to cortisol), cardiomegaly and hypertrophy of the intraventricular septum (functional narrowing of the outflow of the left ventricle and cardiac failure), congenital malformations (most often of the central nervous system and heart). Less common complications in IDMs are: persistent pulmonary hypertension, hyperbilirubinemia, renal vein thrombosis, small left colon syndrome, intrauterine death, polycythemia, and a predisposition to obesity, insulin resistance and diabetes later in life. This article presents current knowledge about pathological conditions and the recommended management for IDMs.

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“…The relation between the incidence of GDM and elevated oxidative stress due to overproduction of reactive oxygen species (ROS) was emphasized by Witczak et al [7] The aim of the study was to determine the prevalence of structural aberrations (CA) in peripheral blood of pregnant women with GDM and umbilical cord blood in neonates.…”

Section: Gestational Diabetes Mellitusmentioning

confidence: 99%

Maternal Diabetes Mellitus – Risk Factor for Fetus and Infant

Lorenc¹,

Otto-Buczkowska²

2018

JED

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Diabetes during pregnancy may occur as pregestational or gestational diabetes mellitus. Throughout gestation there is a close relationship between maternal and fetal blood glucose concentrations. Maternal hyperglycemia leads to hyperglycemia of the fetus, stimulating the fetal pancreas to synthesize excessive amounts of insulin. At the time of delivery, after separation of the placenta, the flow of glucose to the newborn that is appropriate for hyperglycemia is suddenly interrupted. Excessive insulin production in the fetus in response to maternal hyperglycemia can cause severe hypoglycaemia during the neonatal period. It is a very common complication of maternal diabetes. In healthy children during the first 4-6 postnatal hours there is a physiological decrease in glucose levelfrom the mother's blood level to about 2.5 mmol / l (45 mg / dl). This is related to still not fully developed adaptive mechanisms. There is strong evidence that good glycemic control is essential for an optimal outcome of pregnancy in diabetic women. Despite advances in perinatal care, infants of diabetic mothers remain at risk for a multitude of physiologic, metabolic, and congenital complications such as preterm birth, macrosomia, respiratory distress, hypoglycemia, hypocalcemia, hyperbilirubinemia, hypertrophic cardiomyopathy, and congenital anomalies, particularly of the central nervous system.

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What is the impact of gestational diabetes mellitus on frequency of structural chromosome aberrations in pregnant women and their offspring?

Cited by 10 publications

References 29 publications

Is Gestational Diabetes Mellitus a Risk Factor of Maternal Breast Cancer? A Systematic Review of the Literature

Is Gestational Diabetes Mellitus a Risk Factor of Maternal Breast Cancer? A Systematic Review of the Literature

Infant of a diabetic mother: clinical presentation, diagnosis and treatment

Maternal Diabetes Mellitus – Risk Factor for Fetus and Infant

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