What Is the Microbial Profile in Persistent Endodontic Infections? A Scoping Review

Pinto, Karem Paula; Barbosa, Ana Flávia Almeida; Silva, Emmanuel João Nogueira Leal; Santos, Ana Paula Pires dos; Sassone, Luciana Moura

doi:10.1016/j.joen.2023.05.010

Cited by 19 publications

(10 citation statements)

References 57 publications

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“…In this study, ProRoot MTA and MTA Angelus demonstrated superior antimicrobial action with lower colony-forming unit (CFU) values. Previous studies have also highlighted the antimicrobial potential of ProRoot MTA [ 37 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…Certain species can have a crucial impact on a microbial community, ensuring its stability and contributing to the virulence of persistent infections [ 47 ]. Different bacterial strains vary in susceptibility to antimicrobial materials, highlighting the need for testing against multiple strains [ 37 ]. Our study focused on evaluating antimicrobial activity using biofilm microcosm, which mimics natural dental plaque in a lab setting, maintaining its complexity and biodiversity [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Antimicrobial Properties, Cell Viability, and Metalloproteinase Activity of Bioceramic Endodontic Materials Used in Vital Pulp Therapy

Immich,

de Oliveira,

Ribeiro de Andrade

et al. 2024

JFB

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This study aimed to evaluate the antimicrobial properties, cell viability, and matrix metalloproteinase (MMP) inhibition capacity of several endodontic materials aimed at vital pulp therapy: Pro Root MTA®, EndoSequence®, Biodentine®, MTA Angelus®, TheraCal LC®, and BioC Repair®. The materials were prepared according to the manufacturer’s instructions. Antimicrobial tests were conducted using a microcosm biofilm model, cell viability was assessed using murine fibroblasts (L929), and MMP activity was analyzed through electrophoresis. The results showed that BioC Repair®, Biodentine®, and EndoSequence® exhibited similar antimicrobial properties, while MTA Angelus® and ProRoot MTA® had inferior results but were comparable to each other. In terms of cell viability, no significant differences were observed among the materials. EndoSequence® demonstrated the highest MMP inhibition capacity. In conclusion, BioC Repair®, Biodentine®, EndoSequence®, and TheraCal® showed better antimicrobial properties among the tested materials. The materials did not exhibit significant differences in terms of cytotoxicity. However, EndoSequence® displayed superior MMP inhibition capacity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of Antimicrobial Properties, Cell Viability, and Metalloproteinase Activity of Bioceramic Endodontic Materials Used in Vital Pulp Therapy

Immich,

de Oliveira,

Ribeiro de Andrade

et al. 2024

JFB

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“…Additionally, Porphyromonas gingivalis, Treponema denticola, Prevotella intermedia, Porphyromonas endodontalis and Dialister pneumosintes were identi ed as key pathogens in root canal infections [23,25,33]. Therefore, this study postulates that dental tissue infections, such as periodontitis and root canal infections, may act as triggering factors for the occurrence of MRONJ or play a facilitating role in the progression of this condition.…”

Section: Discussionmentioning

confidence: 89%

Analysis of oral microbiota diversity in Medication-Related Osteonecrosis of the Jaws based on 16S rDNA sequencing: A preliminary research

Cao,

Zhang

2024

Preprint

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Purpose: The aim of this study was to explore the diversity of oral flora in MRONJ patients and assess the differences between MRONJ patients and individuals with common oral infections. Methods: We investigated the oral microbial species and diversity of 33 subjects (10 in group R1, MRONJ patients; 6 in group R2, patients who have used antiresorptive drugs but without MRONJ; 9 in group R3, patients without history of antiresorptive drugs but have oral infection; 8 in group C, healthy controls without oral disease) , through the utilization of 16S rDNA amplicon sequencing technology. Results: MRONJ patients (group R1) exhibited a higher species diversity of oral flora. The oral microbiota composition of patients in the group R1 was significantly different from that of the group C. Dominant microbes in the R1 group included Porphyromonas gingivalis, Treponema denticola, Prevotella intermedia, Prevotella nigrescens, Campylobacter showae, Porphyromonas endodontalis and Dialister pneumosintes, which are closely associated with the pathogens of dental infections. There was a significant difference in the oral microbiota between group R1 and group R3, with some microbial communities having a significantly higher relative abundance in the R1 group. These differential communities at the genus level included Prevotella and Ligilactobacillus, and at the species level, Prevotella intermedia was notable. In this study, the oral microbiota composition of patients in the group R2 showed no significant differences compared to the group C. Conclusion: Although the sample size is small, the results of this study preliminarily demonstrate the oral microbial diversity in patients with MRONJ. The dominant oral microbiota in MRONJ patients, closely related to periodontitis and root canal infections, suggests that infections associated with dental tissue could be potential factors leading to the onset or exacerbation of MRONJ.

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“… 2 , 3 Most clinical reports have focused on the role of T. forsythia in periodontitis. 4 , 5 However, reports on its role in infection of the lower respiratory tract and other tissues is limited. This bacteria was determined as the pathogen for these reasons: (1) The patient had suffered from severe periodontitis; (2) Though only one BALF sample detected the bacteria by mNGS, the mNGS detection report usually can be considered reliable because of its high specificity; (3) The patient had no fever, cough, expectoration, that is, the symptoms that would be induced by infection of common pathogens for abscess such as staphylococcus aureus and anaerobic bacteria; (4) The therapy was effective.…”

Section: Discussionmentioning

confidence: 99%

Lung abscess caused by the anaerobic pathogen Tannerella forsythia

Miao,

Yang,

Wang

et al. 2024

Respirology Case Reports

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Odontogenic infections can spread to the respiratory tract. Despite the known role of Tannerella forsythia as the primary pathogen in periodontitis, the association between T. forsythia infection and risk of pneumonia or lung abscess remains unknown. In this report, we present a case of lung abscess caused by T. forsythia infection. The pathogen was detected by metagenomic next‐generation sequencing (mNGS) in the bronchoalveolar lavage fluid of the patient. The clinical characteristics and possible mechanisms of the infection are discussed. T. forsythia is a conditional pathogen that can cause lung abscess in the presence of helper bacteria and reduced host immune status. The course of treatment should be personalized and might be longer than 3 months.

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What Is the Microbial Profile in Persistent Endodontic Infections? A Scoping Review

Cited by 19 publications

References 57 publications

Evaluation of Antimicrobial Properties, Cell Viability, and Metalloproteinase Activity of Bioceramic Endodontic Materials Used in Vital Pulp Therapy

Evaluation of Antimicrobial Properties, Cell Viability, and Metalloproteinase Activity of Bioceramic Endodontic Materials Used in Vital Pulp Therapy

Analysis of oral microbiota diversity in Medication-Related Osteonecrosis of the Jaws based on 16S rDNA sequencing: A preliminary research

Lung abscess caused by the anaerobic pathogen Tannerella forsythia

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