What is the optimal management for the asymptomatic twin after diagnosis of late-onset group B streptococcal disease?

Feildel‐Fournial, Cécile; Launay, Élise; Caillon, Jocelyne; Thomas, E.; Boscher, Cécile; Guen, Christèle Gras‐Le

doi:10.1136/archdischild-2018-316170

Cited by 4 publications

(7 citation statements)

References 36 publications

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“…Two women were not breastfeeding when iGBS occurred in their infants. The median duration of antibiotic treatment for GBS bacteremia was 14 (10)(11)(12)(13)(14)(15)(16)(17)(18)(19) days and 20 (14-21) days for meningitis. 10/16 infants with detailed medical records received at least one course of antibiotics prior to onset of iGBS; four of them for more than seven days.…”

Section: German/swiss Cohort Demographic and Clinical Characteristicsmentioning

confidence: 99%

“…Three out of nine cases with a lumbar puncture had a concurrent meningitis. The first episode was treated with antibiotics for 14 (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21) days. Recurrence of iGBS occurred at a median age of 44 (24-64) days.…”

Section: German/swiss Case Series Demographic and Clinical Characteristicsmentioning

confidence: 99%

“…The median duration of antibiotic therapy for the second episode was 14 (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) days. GBS capsular serotyping was performed in one (8%) case (serotype III ST-17).…”

Section: German/swiss Case Series Demographic and Clinical Characteristicsmentioning

confidence: 99%

“…The management of twins of iGBS cases has been the subject of several papers and guidelines (15,18,21,36). Current NICE guidelines recommend antibiotic treatment of the other multiple(s) in case of confirmed or suspected EOS, however, no recommendations for LOS are provided (37).…”

Section: How To Prevent Infection Of the Asymptomatic Sibling And Recurrence In Gbs Diseasementioning

confidence: 99%

“…The increased risk of multiple pregnancies for preterm delivery and adverse outcomes in general is well established ( 17 ), yet uncertainty exists about the specific association with iGBS. In part due to the lack in understanding of disease pathogenesis, there is no consensus about the management of the asymptomatic sibling of an iGBS case from a multiple birth ( 18 )⁠. Additionally, the mechanisms underlying recurrent disease are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

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Invasive Group B Streptococcus Disease With Recurrence and in Multiples: Towards a Better Understanding of GBS Late-Onset Sepsis

et al. 2021

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Group B Streptococcus (GBS) is a common intestinal colonizer during the neonatal period, but also may cause late-onset sepsis or meningitis in up to 0.5% of otherwise healthy colonized infants after day 3 of life. Transmission routes and risk factors of this late-onset form of invasive GBS disease (iGBS) are not fully understood. Cases of iGBS with recurrence (n=25) and those occurring in parallel in twins/triplets (n=32) from the UK and Ireland (national surveillance study 2014/15) and from Germany and Switzerland (retrospective case collection) were analyzed to unravel shared (in affected multiples) or fixed (in recurrent disease) risk factors for GBS disease. The risk of iGBS among infants from multiple births was high (17%), if one infant had already developed GBS disease. The interval of onset of iGBS between siblings was 4.5 days and in recurrent cases 12.5 days. Disturbances of the individual microbiome, including persistence of infectious foci are suggested e.g. by high usage of perinatal antibiotics in mothers of affected multiples, and by the association of an increased risk of recurrence with a short term of antibiotics [aOR 4.2 (1.3-14.2), P=0.02]. Identical GBS serotypes in both recurrent infections and concurrently infected multiples might indicate a failed microbiome integration of GBS strains that are generally regarded as commensals in healthy infants. The dynamics of recurrent GBS infections or concurrent infections in multiples suggest individual patterns of exposure and fluctuations in host immunity, causing failure of natural niche occupation.

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Section: German/swiss Cohort Demographic and Clinical Characteristicsmentioning

confidence: 99%

Section: German/swiss Case Series Demographic and Clinical Characteristicsmentioning

confidence: 99%

Section: German/swiss Case Series Demographic and Clinical Characteristicsmentioning

confidence: 99%

Section: How To Prevent Infection Of the Asymptomatic Sibling And Recurrence In Gbs Diseasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Invasive Group B Streptococcus Disease With Recurrence and in Multiples: Towards a Better Understanding of GBS Late-Onset Sepsis

et al. 2021

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Infecciones por estreptococo del grupo B

Launay

Guen

2022

EMC - Pediatría

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Late‐onset group B Streptococcus infection in twins due to capsular polysaccharides type IV

Takahashi,

Murase,

Noguchi

et al. 2024

Pediatrics International

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What is the optimal management for the asymptomatic twin after diagnosis of late-onset group B streptococcal disease?

Cited by 4 publications

References 36 publications

Invasive Group B Streptococcus Disease With Recurrence and in Multiples: Towards a Better Understanding of GBS Late-Onset Sepsis

Invasive Group B Streptococcus Disease With Recurrence and in Multiples: Towards a Better Understanding of GBS Late-Onset Sepsis

Infecciones por estreptococo del grupo B

Late‐onset group B Streptococcus infection in twins due to capsular polysaccharides type IV

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