What is the pathogenesis of proximal hypospadias?

Acimi, Smaïl

doi:10.5152/tud.2018.85530

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…However, most of the parents and families of those with hypospadias experience anxiety and uncertainty regarding the information about hypospadias [ 2 ]. Moreover, there remains some confusion in the diagnosis of hypospadias even among clinicians [ 3 ]. The confusion among both clinicians and parents delays the diagnosis and treatment of hypospadias, exacerbating the symptoms and lowering the quality of life of those affected [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Digital Pattern Recognition for the Identification of Various Hypospadias Parameters via an Artificial Neural Network: Protocol for the Development and Validation of a System and Mobile App

Wahyudi¹,

Utomo²,

Djauzi³

et al. 2022

JMIR Res Protoc

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Background Hypospadias remains the most prevalent congenital abnormality in boys worldwide. However, the limited infrastructure and number of pediatric urologists capable of diagnosing and managing the condition hinder the management of hypospadias in Indonesia. The use of artificial intelligence and image recognition is thought to be beneficial in improving the management of hypospadias cases in Indonesia. Objective We aim to develop and validate a digital pattern recognition system and a mobile app based on an artificial neural network to determine various parameters of hypospadias. Methods Hypospadias and normal penis images from an age-matched database will be used to train the artificial neural network. Images of 3 aspects of the penis (ventral, dorsal, and lateral aspects, which include the glans, shaft, and scrotum) will be taken from each participant. The images will be labeled with the following hypospadias parameters: hypospadias status, meatal location, meatal shape, the quality of the urethral plate, glans diameter, and glans shape. The data will be uploaded to train the image recognition model. Intrarater and interrater analyses will be performed, using the test images provided to the algorithm. Results Our study is at the protocol development stage. A preliminary study regarding the system’s development and feasibility will start in December 2022. The results of our study are expected to be available by the end of 2023. Conclusions A digital pattern recognition system using an artificial neural network will be developed and designed to improve the diagnosis and management of patients with hypospadias, especially those residing in regions with limited infrastructure and health personnel. International Registered Report Identifier (IRRID) PRR1-10.2196/42853

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Section: Introductionmentioning

confidence: 99%

Digital Pattern Recognition for the Identification of Various Hypospadias Parameters via an Artificial Neural Network: Protocol for the Development and Validation of a System and Mobile App

Wahyudi¹,

Utomo²,

Djauzi³

et al. 2022

JMIR Res Protoc

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“…T he term hypospadias is a Greek word composed of two words: hypo (νπο) which mean under and spathe (σπαδη) which mean sword. [ 1 ] It is due to the defect of distal corpus spongiosum and urethra. Thus, hypospadias is characterized by ectopia of the urethral meatus, a meatus located on the ventral side of the penis or on the scrotal area.…”

Section: Introductionmentioning

confidence: 99%

Anatomical explanations of the pathogenesis of proximal hypospadias

Acimi

2019

J Indian Assoc Pediatr Surg

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Aims:The aim of this study was to try to explain the pathogenesis of proximal hypospadias based on anatomical and histological findings.Methods:During 9 years, we performed systematic biopsies (in the lateral areas of the urethral plate, as well as under this plate) in 81 patients treated for proximal hypospadias. The histological study was performed by routine coloring, hematoxylin and eosin, and Masson's trichrome, which colors the collagen fibers in blue, and monoclonal antibody against alpha-smooth muscle actin.Results:There is a fibrosis tissue abnormally present on the ventral side of the penis. This tissue consists of a mixture of fibrous connective tissue, nerve nets, short vessels, and smooth muscle fibers. The penis' dartos does not contain smooth muscle fibers. These fibers can come from a blood vessel or spongy tissue which existed during the neonatal period in the distal part of the penis before disappearing.Conclusions:The proximal hypospadias is due presumably to avascular necrosis of the distal part poorly vascularized of the corpus spongiosum.

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Managing hypospadias in a tertiary hospital in northern Ghana: a retrospective study

Yenli,

Bimpong,

Cheyuo

et al. 2023

African Urology

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What is the pathogenesis of proximal hypospadias?

Abstract: These findings allow us to suggest that the proximal hypospadias is due to avascular necrosis of the distal part ie. poorly vascularized part of the corpus spongiosum.

Cited by 3 publications

References 16 publications

Digital Pattern Recognition for the Identification of Various Hypospadias Parameters via an Artificial Neural Network: Protocol for the Development and Validation of a System and Mobile App

Digital Pattern Recognition for the Identification of Various Hypospadias Parameters via an Artificial Neural Network: Protocol for the Development and Validation of a System and Mobile App

Anatomical explanations of the pathogenesis of proximal hypospadias

Managing hypospadias in a tertiary hospital in northern Ghana: a retrospective study

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