What is the preferred GnRH analogue for polycystic ovary syndrome patients undergoing controlled ovarian hyperstimulation for in vitro fertilization?

Orvieto, Raoul; Meltcer, Simion; Homburg, Roy; Nahum, Ravit; Rabinson, Jacob; Ashkenazi, Jacob

doi:10.1016/j.fertnstert.2008.07.1711

Cited by 23 publications

(23 citation statements)

References 14 publications

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“…This may be explained by better quality embryos in agonist group. This agrees with the work of Orvieto et al 30 On the contrary, a study done by Al-Inany et al (28 RCTs involving 5014 women) compared GnRH agonist and GnRH antagonist showed that there was no significant difference in pregnancy rate between the two regimens. 32 The difference between this study and the current study may be due to the different antagonist protocols used and different patient characteristics (PCOS and poor responders).…”

Section: Discussionsupporting

confidence: 91%

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Fixed gonadotropin-releasing hormone antagonist protocol versus gonadotropin-releasing hormone agonist long protocol in patients with polycystic ovary syndrome treated for intracytoplasmic sperm injection cycles

Khalifa

Orief

Said

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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Section: Discussionsupporting

confidence: 91%

“…30 In contrast, Singh et al demonstrated that there was no significant difference in the estrogen level in hCG day. 29 This difference may be due to small number of cases in antagonist group.…”

Section: Discussionmentioning

confidence: 94%

Fixed gonadotropin-releasing hormone antagonist protocol versus gonadotropin-releasing hormone agonist long protocol in patients with polycystic ovary syndrome treated for intracytoplasmic sperm injection cycles

Khalifa

Orief

Said

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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“…In addition, no difference in serum RBP4 levels was observed between ovulatory and anovulatory PCOS patients (Carmina et al 2009). In PCOS patients who underwent controlled ovarian hyperstimulation for an IVF-embryo transfer, serum RBP4 was found to be significantly decreased during the process (Orvieto et al 2010). But there is no correlation between serum RBP4 levels and IVF treatment variables or outcome.…”

Section: Retinol Binding Protein-4mentioning

confidence: 94%

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Chen¹,

Jia²,

Qiao³

et al. 2013

Journal of Molecular Endocrinology

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Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Dysfunction of adipose tissue has been implicated in the pathophysiology of PCOS. Increasing evidence shows that the dysregulated expression of adipokines, the secreted products of adipose tissue, plays an important role in the pathology of PCOS. Here, we review the role of several identified adipokines that may act as a link between obesity and PCOS. PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome.

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“…The chronic anovulation and infertility is often successfully treated in PCOS; however, resultant successful pregnancy rates are lower than expected (33,34). Recurrent miscarriage is also common in women with PCOS (18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

“…The population consisted of 42 women with normal ovarian function undergoing IVF-ET due to their husbands suffering from azoospermia. The mean age was 27.5±2.8 years (range, [25][26][27][28][29][30][31][32][33][34], and mean BMI was 19.11±1.12 kg/m 2 (range, 16.01-23.58). They had regular menstrual cycle lengths between 25-35 days.…”

Section: Methodsmentioning

confidence: 99%

HOXA10 expression is decreased by testosterone in luteinized granulosa cells in vitro

Tian

Yin

et al. 2012

Mol Med Report

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Abstract. Polycystic ovary syndrome (PCOS) is perhaps the most prevalent endocrine disorder in women of reproductive age, characterized by elevated levels of circulating androgens or clinical manifestations of androgen excess. The specific cytokine profile of PCOS patients is probably related to the lower implantation rate, since follicular fluid appears to function as an embryotrophic agent. For a better understanding of the local regulation of human follicles, the present study investigated the protein expression levels and cellular localization of HOXA10 in granulosa cells (GCs) from women with normal ovarian function undergoing IVF due to their husbands suffering from azoospermia. We demonstrated by immunohistochemical studies that the expression of HOXA10 was mainly localized in the cytoplasm of GCs. Our data indicate that these alterations were associated with changes in the expression of ovarian transcription factors of HOXA10. GC dose-responsive decreases in HOXA10 protein were observed in response to physiological or supraphysiological concentrations (10 -4 to 10 -7 M) of testosterone. These data reveal that testosterone may be involved in HOXA10 gene regulation in GCs. Decreased HOXA10 expression in GCs treated with testosterone suggest that this androgen is responsible for the decreased expression of HOXA10 in PCOS patients.

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What is the preferred GnRH analogue for polycystic ovary syndrome patients undergoing controlled ovarian hyperstimulation for in vitro fertilization?

Cited by 23 publications

References 14 publications

Fixed gonadotropin-releasing hormone antagonist protocol versus gonadotropin-releasing hormone agonist long protocol in patients with polycystic ovary syndrome treated for intracytoplasmic sperm injection cycles

Fixed gonadotropin-releasing hormone antagonist protocol versus gonadotropin-releasing hormone agonist long protocol in patients with polycystic ovary syndrome treated for intracytoplasmic sperm injection cycles

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

HOXA10 expression is decreased by testosterone in luteinized granulosa cells in vitro

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