The climatic conditions on Mars are significantly different from those on Earth, which is the main factor affecting the potential architectural solutions on this planet. Above all, high levels of cosmic radiation of solar and extragalactic origin require specific architectural solutions, such as a safe location and sufficient protection, which are determined by a complex set of factors. These factors include the accessibility of building materials on site, the range and predictability of changes in climatic conditions, and human needs. In this article, the significant influence of radiation on architecture, which should be addressed when planning temporary or permanent resilient settlements on Mars, is examined in the case of manned missions to the planet. For this purpose, a comprehensive literature review is conducted, focused on the latest radiation-related discoveries. As the main outcome, two main schematic architectural solutions are proposed as a step toward more advanced projects. In addition, the gaps that need to be filled in the current approach to the design process, related to the insufficiently strong focus on multidisciplinary site analysis with radiation as its main factor (as is necessary for erecting an inhabitable base) are addressed.