What is the relationship between spermatozoa per milliliter at adulthood and the tubular fertility index at surgical age for patients with cryptorchidism?

Gracia, J.; Sánchez, Javier; Garcia, C.; Pueyo, Carmen Lahuerta; Ferrández, Ángel

doi:10.1016/s0022-3468(98)90323-2

Cited by 12 publications

(5 citation statements)

References 9 publications

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“…1; the relationship was not significant ( r = − 0.07 in unilateral and r = 0.20 in bilateral cases). There were significant correlations between the sperm count and the level of FSH ( r = − 0.41) and LH ( r = − 0.29), but there was no significant correlation between the sperm count in adulthood and the tubular fertility index in childhood [3]. There were no significant correlations between the sperm density and age at surgery either in unilateral or bilateral cases, and no significant differences either in the sperm count with different testicular location ( anova ) or between patients treated or untreated with βhCG in childhood.…”

Section: Resultsmentioning

confidence: 99%

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Clinical, physical, sperm and hormonal data in 251 adults operated on for cryptorchidism in childhood

Gracia¹,

Zalabardo

García³

et al. 2000

BJU International

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Objective To determine the clinical, physical, sperm and hormonal status during adulthood in cryptorchid patients operated on during childhood, and to assess these variables according to the age at surgery and preoperative testicular position. Patients and methods A letter was sent to all 890 patients > 18 years old who underwent surgery for cryptorchidism during childhood; 274 responded and were assessed using a sexual history, physical examination, pituitary axis study and sperm analysis. Data were complete for 251 patients (mean age 21 years, range 18±30); 196 had unilateral (25 anorchic) and 55 had bilateral cryptorchidism. Clinical, surgical and anatomopathological records at surgery during childhood were also reviewed. Results The mean (SD) age at orchidopexy was 6.4 (3.3) years and the mean age at assessment 21.1 (2.7) years. Semen samples generally showed abnormalities; 10 patients (4%) with bilateral and 57 (23%) with unilateral cryptorchidism had semen values within the normal range. There was no correlation between the sperm count and age at surgery for unilateral or bilateral cases (Spearman test). There was a signi®cant correlation (r = x 0.41) between the sperm count and level of folliclestimulating hormone (FSH). There were no signi®cant differences in the sperm count for patients with different testicular locations (ANOVA) or in those treated or untreated with human chorionic gonadotrophin (Student's t-test). The only signi®cant relationship (P < 0.001) was between the sperm count and unilateral or bilateral cryptorchidism. Conclusions The sperm quality of adults operated on for cryptorchidism during childhood is independent of the age at surgery or testicular location, but is in¯uenced by whether the cryptorchidism was unilateral or bilateral. FSH levels were negatively correlated with sperm density.

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Section: Resultsmentioning

confidence: 99%

“…Only those patients with complete data (hormonal and sperm) were analysed for the purposes of the present study. The classification of testicular position, the percentage of patients who received βhCG treatment, the surgical technique used for the orchidopexy and the anatomopathological protocol were described previously [2,3].…”

Section: Methodsmentioning

confidence: 99%

Clinical, physical, sperm and hormonal data in 251 adults operated on for cryptorchidism in childhood

Gracia¹,

Zalabardo

García³

et al. 2000

BJU International

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“…roughly if no germ cellsare present in the biopsy), there is a great risk of infertilitylater in life [21]. However, the prognostic relevance of tubular fertility index was questioned as a predictor of the potential fertility in cryptorchidism [22, 23]. With determination of Ad spermatogonia as a prognostic parameter, the pathologist has an additional tool that has an excellent predictive value for future fertility outcome and discovers those patients who may benefit from hormonal treatment.…”

Section: Discussionmentioning

confidence: 99%

Infertility in Cryptorchidism Is Linked to the Stage of Germ Cell Development at Orchidopexy

et al. 2007

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Background: Cryptorchidism represents the most common endocrine disease in boys, with infertility frequently observed in unilateral as well as bilateral forms. In this study, we examined the role of Ad (dark) spermatogonia for fertility in cryptorchid boys. The hypothesis to be proven was that boys lacking Ad spermatogonia will develop infertility despite a successful orchidopexy at an early age. Methods: To estimate total sperm count, one of the most predictive parameters of male fertility, we analyzed the ejaculatein 218 cryptorchid men and correlated it with the developmental stage of their germ cells at the time of successful surgery. Results: Abnormal sperm concentration (<40 × 10⁶/ejaculate) was found in half of the patients under the study. 47.5% of unilateral and 78% of bilateral cryptorchid males had their sperm concentration in the infertility range according to the WHO standards. If transformation into Ad spermatogonia had occured, age-related differences in the fertility outcome was observed. The younger the unilateral cryptorchid boys were at surgery, the higher their sperm count. Age-related difference was not found in the group of cryptorchid men having had no A dark spermatogonia at time of surgery, indicating that in this group a successful orchidopexy is insufficient to prevent infertility development and, in particular, the development of azoospermia. Conclusion: The presence of Ad spermatogonia at surgery is an excellent prognostic parameter for future fertility. Cryptorchid boys lacking these cells will develop infertility despite successful orchidopexy at an early age.

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“…Equivalently, others have reported that G/T at the time of surgery of unilateral and bilateral cryptorchid patients analyzed together correlated to later sperm concentration [19,200,201,202,203]. However, others did not find any correlation between prepubertal histological findings and adult semen parameters [187,204] but they only quantified the “tubular fertility index” defined as the number of tubules with spermatogonia/total number of counted tubules.…”

Section: Cryptorchidismmentioning

confidence: 99%

Clinical aspects of histological and hormonal parameters in boys with cryptorchidism

Hildorf

2022

APMIS

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What is the relationship between spermatozoa per milliliter at adulthood and the tubular fertility index at surgical age for patients with cryptorchidism?

Cited by 12 publications

References 9 publications

Clinical, physical, sperm and hormonal data in 251 adults operated on for cryptorchidism in childhood

Clinical, physical, sperm and hormonal data in 251 adults operated on for cryptorchidism in childhood

Infertility in Cryptorchidism Is Linked to the Stage of Germ Cell Development at Orchidopexy

Clinical aspects of histological and hormonal parameters in boys with cryptorchidism

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