2013
DOI: 10.4161/derm.23773
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What is the relationship between ultraviolet B and global incidence rates of colorectal cancer?

Abstract: The purpose of this study is to examine the relationship between ultraviolet B and global incidence of colorectal cancer, while controlling for relevant covariates. Linear regression was used to assess the relationship between latitude and incidence rates of colon cancer in 173 countries. Multiple linear regression was employed to investigate the relationship between ultraviolet B dose and colorectal cancer rates while controlling for per capita intake of energy from animal sources, per capita health expenditu… Show more

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Cited by 18 publications
(36 citation statements)
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“…[15] We found breast, prostate and colon cancers decrease with increasing UVB dose (or increasing latitude), which agrees with others who found breast, [70] prostate [71] and colon [72] cancers decrease with increasing UVB dose, [73] decreasing latitude [74] or increasing vitamin D 3 . [75] We expanded on those findings by analyzing the different skin types in five age groups to find only the whites, but not the blacks, oldest age group (70-85+) have significant negative slopes.…”
Section: Discussionsupporting
confidence: 91%
“…[15] We found breast, prostate and colon cancers decrease with increasing UVB dose (or increasing latitude), which agrees with others who found breast, [70] prostate [71] and colon [72] cancers decrease with increasing UVB dose, [73] decreasing latitude [74] or increasing vitamin D 3 . [75] We expanded on those findings by analyzing the different skin types in five age groups to find only the whites, but not the blacks, oldest age group (70-85+) have significant negative slopes.…”
Section: Discussionsupporting
confidence: 91%
“…On the other hand, the incidence of colorectal cancers was significantly decreased in patients with NMSC in our study. This might be explained by the relationship between UVB‐induced vitamin D production and a decreased risk of colorectal cancer . A study of the global incidence of colorectal cancer in 173 countries revealed that UVB was inversely associated with colorectal cancer, and modelled serum 25‐hydroxyvitamin D also showed an inverse association in a dose‐response analysis .…”
Section: Discussionmentioning
confidence: 99%
“…8,16 A study of the global incidence of colorectal cancer in 173 countries revealed that UVB was inversely associated with colorectal cancer, and modelled serum 25-hydroxyvitamin D also showed an inverse association in a dose-response analysis. 16 UVB irradiation produces vitamin D in the skin, which significantly reduces risk of many cancers. 8 Further study is needed to verify the association with NMSC and decreased risk of colorectal cancer.…”
Section: Discussionmentioning
confidence: 99%
“…This pattern has held true for cancers of the colon [8], breast [9], pancreas [10], ovary [11], brain [12], bladder [13], kidney [14], and multiple myeloma [15].…”
Section: Impact Of Sunlight And/or Vitamin D On Specific Health Condimentioning
confidence: 93%
“…Moreover, they neglect that we have evolved with physiological adaptations to help protect the skin from the sun [5] when we are mindful of our exposure and do not burn. They neglect the fact that increased sun exposure, based on latitude, has been associated with protection from several different types of cancer [6][7][8][9][10][11][12][13][14][15], type 1 diabetes [16], multiple sclerosis [17,18], and other diseases [19][20][21][22][23]. They also neglect the fact that exposure to the sun induces beneficial physiological changes beyond the production of vitamin D. Though adherence to the current sun-protective recommendations would likely result in the reduction of nonmelanoma skin cancer, that reduction would likely be overshadowed by the potential reduction in deaths from other cancers and from cardiovascular disease, which could be achieved by doubling average blood concentrations of 25-hydroxyvitamin D (25 (OH)D) to 40 ng/mL through a combination of sun exposure and supplements [24].…”
Section: Introductionmentioning
confidence: 99%