2022
DOI: 10.1212/wnl.0000000000201505
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What Is the Role of Dorsal Horn Astrocytes in Chronic Pain and Itch?

Abstract: Astrocytes include different subtypes and exert multiple functions critical for synaptic communication and network activity in the CNS.1 They may ensheath up to million synapses in the human brain2; maintain water, potassium (K+), and glutamate homeostasis after synaptic activity3,4; form a structural barrier around synapses preventing glutamate spillover5; provide lactate as an energy substrate for neurons6; release neurochemical signals that mediate paracrine interactions with neurons and other glial cells7;… Show more

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Cited by 2 publications
(1 citation statement)
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“…In a mouse model study by Liu et al, Toll-like receptor 4 (TLR4) was discovered to be involved in both astrocyte activation and chronic itch ( Liu et al, 2016 ). Other receptors include the IL-33 receptor, ST2, and the chemokine receptor, CXCR3, although further studies exploring the role of these receptors in the context of glial inflammation and chronic itch are needed ( Benarroch, 2022 ). Reactive astrocytes may play a role in central sensitization in the context of mechanical itch, although further studies are needed in this area.…”
Section: Central Neural Sensitization In Chronic Itchmentioning
confidence: 99%
“…In a mouse model study by Liu et al, Toll-like receptor 4 (TLR4) was discovered to be involved in both astrocyte activation and chronic itch ( Liu et al, 2016 ). Other receptors include the IL-33 receptor, ST2, and the chemokine receptor, CXCR3, although further studies exploring the role of these receptors in the context of glial inflammation and chronic itch are needed ( Benarroch, 2022 ). Reactive astrocytes may play a role in central sensitization in the context of mechanical itch, although further studies are needed in this area.…”
Section: Central Neural Sensitization In Chronic Itchmentioning
confidence: 99%