What is the Significance of the In Transit or Interval Sentinel Node in Melanoma?

Zager, Jonathan S.; Puleo, Christopher A.; Sondak, Vernon K.

doi:10.1245/s10434-011-1996-5

Cited by 23 publications

(11 citation statements)

References 10 publications

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“…The pathologist obtains multiple sections from the SLN and uses sensitive and specific staining techniques to identify even single-cell metastases. SLNs are found to contain metastases in about 20 % of patients [20][21][22][23][24].…”

Section: Background and Definitionsmentioning

confidence: 99%

EANM practice guidelines for lymphoscintigraphy and sentinel lymph node biopsy in melanoma

Bluemel

Herrmann

Giammarile

et al. 2015

Eur J Nucl Med Mol Imaging

118

131

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Section: Background and Definitionsmentioning

confidence: 99%

EANM practice guidelines for lymphoscintigraphy and sentinel lymph node biopsy in melanoma

Bluemel

Herrmann

Giammarile

et al. 2015

Eur J Nucl Med Mol Imaging

118

131

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“…Controversies exist in the nomenclature of these nodes found between the primary tumor and a major basin, which can be named as interval nodes, in transit nodes (ITN), aberrant, or atypical nodes. As the management and the impact of these situations have been reported in a similar way, in this article, sentinel nodes not found in major basins will be referred to as ITN, as previously proposed by other authors …”

Section: Introductionmentioning

confidence: 78%

“…There are few studies that have evaluated clinical impact of ITN, and some of them have used methods different than ours . None of them have found worse outcomes in patients with sentinel nodes in atypical location.…”

Section: Discussionmentioning

confidence: 94%

In transit sentinel node drainage as a prognostic factor for patients with cutaneous melanoma

Brandão

Bertolli

Doria-Filho

et al. 2018

Journal of Surgical Oncology

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“…18 Another advantage of SPECT/CT is the ability to identify and localize unusual lymphatic drainage to interval and minor nodal basin nodes. This was clearly depicted in one of our patients with a left shoulder melanoma primary (Fig.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Single-Photon Emission Computed Tomography–Computed Tomography (SPECT/CT) and Conventional Planar Lymphoscintigraphy for Sentinel Node Localization in Patients with Cutaneous Malignancies

et al. 2016

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Background Accurate preoperative lymphoscintigraphy is vital to performing sentinel lymph node biopsy (SLNB) for cutaneous malignancies. Potential advantages of single-photon emission computed tomography with integrated computed tomography (SPECT/CT) include the ability to readily identify aberrant drainage patterns as well as provide the surgeon with three-dimensional anatomic landmarks not seen on conventional planar lymphoscintigraphy (PLS). Methods Patients with cutaneous malignancies who underwent SLNB with preoperative imaging using both SPECT/CT and PLS from 2011 to 2014 were identified. Results Both SPECT/CT and PLS were obtained in 351 patients (median age, 69 years; range, 5–94 years) with cutaneous malignancies (melanoma = 300, Merkel cell carcinoma = 33, squamous cell carcinoma = 8, other = 10) after intradermal injection of 99mtechnetium sulfur colloid (median dose 300 μCi). A mean of 4.3 hot spots were identified on SPECT/CT compared to 3.0 on PLS (p < 0.001). One hundred fifty-three patients (43.6 %) had identical findings between SPECT/CT and PLS, while 172 (49 %) had additional hot spots identified on SPECT/CT compared to only 24 (6.8 %) additional on PLS. SPECT/CT demonstrated additional nodal basins in 103 patients (29.4 %), compared to only 11 patients (3.1 %) with additional basins on PLS. Conclusions SPECT/CT is a useful adjunct that can help with sentinel node localization in challenging cases. It identified additional hot spots not seen on PLS in almost 50 % of patients. Because PLS identified hot spots not seen on SPECT/CT in 6.8 % of patients, we recommend using both modalities jointly. Long-term follow-up will be required to validate the clinical significance of the additional hot spots identified by SPECT/CT.

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What is the Significance of the In Transit or Interval Sentinel Node in Melanoma?

Cited by 23 publications

References 10 publications

EANM practice guidelines for lymphoscintigraphy and sentinel lymph node biopsy in melanoma

EANM practice guidelines for lymphoscintigraphy and sentinel lymph node biopsy in melanoma

In transit sentinel node drainage as a prognostic factor for patients with cutaneous melanoma

Comparison of Single-Photon Emission Computed Tomography–Computed Tomography (SPECT/CT) and Conventional Planar Lymphoscintigraphy for Sentinel Node Localization in Patients with Cutaneous Malignancies

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