What is the value of electromagnetic navigation in lung cancer and to what extent does it require improvement?

Shaller, Brian D.; Gildea, Thomas R.

doi:10.1080/17476348.2020.1748012

Cited by 8 publications

(5 citation statements)

References 72 publications

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“…However, both VBN and ENB heavily rely on the CT images transferred to the navigation system. Discrepancy between the inspiratory and expiratory phase‐CT scans, CT measurement algorithm errors, airway structural variation, and sputum blocking could commonly give rise to the deviation of planned path in navigation system, and at this point, manual segmentation is needed 10,16,17 . A sophisticated bronchoscopist can recognize the bronchi and draw the MN map by repeatedly reading three‐dimensional multiplanar reconstruction CT images.…”

Section: Discussionmentioning

confidence: 99%

“…Discrepancy between the inspiratory and expiratory phase‐CT scans, CT measurement algorithm errors, airway structural variation, and sputum blocking could commonly give rise to the deviation of planned path in navigation system, and at this point, manual segmentation is needed. 10 , 16 , 17 A sophisticated bronchoscopist can recognize the bronchi and draw the MN map by repeatedly reading three‐dimensional multiplanar reconstruction CT images. More importantly, truly knowing and understanding the bronchial pathway will absolutely be helpful for the bronchoscopist to find the target lesion faster.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic outcomes of radial endobronchial ultrasound bronchoscopy guided by manual navigation in the evaluation of peripheral pulmonary lesions: An observational study

Yuan,

Hu,

Wang

et al. 2024

Clinical Respiratory J

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Background and AimsManual navigation (MN), drawing a bronchoscopic road map simply by looking at the consecutive computed tomography (CT), is feasible and economical. However, scant data about the use of MN in radial endobronchial ultrasound (r‐EBUS) bronchoscopy have been documented till now. We aimed to evaluate the diagnostic performance of r‐EBUS bronchoscopy guided by MN for diagnosing peripheral pulmonary lesions (PPLs) and to determine clinical factors affecting the diagnostic yield.MethodsWe performed a retrospective, cohort study of consecutive patients with PPLs who underwent r‐EBUS bronchoscopic biopsy via guidance of MN from May 2020 to June 2021 in our Respiratory Endoscopic Division. The overall diagnostic yield of MN‐guided r‐EBUS, the factors affecting the yield, and the diagnostic performance for malignancy were evaluated.ResultsA total of 102 patients (103 lesions) were evaluated. The overall diagnostic yield of MN‐guided r‐EBUS was 82.0%, and it ranged from 79.6% to 82.5%, assuming the undermined cases were all positive cases (79.6%) or negatives (82.5%). The sensitivity of MN‐guided r‐EBUS for malignancy was 71.4%, ranging from 68.2% to 71.4%, the specificity was 100%, the positive predictive value was 100%, and the negative predictive value was 67.3%, ranging from 63.8% to 69.0%. The multivariate logistic regression showed that “bronchus sign on CT” was the only predictor of the overall diagnostic yield (odds ratio = 11.5, 95% confidence interval: 1.9–70.9, P = 0.009).ConclusionsMN‐guided r‐EBUS is feasible in diagnosing PPLs, especially for lesions with bronchus sign on CT.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diagnostic outcomes of radial endobronchial ultrasound bronchoscopy guided by manual navigation in the evaluation of peripheral pulmonary lesions: An observational study

Yuan,

Hu,

Wang

et al. 2024

Clinical Respiratory J

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“…In clinical scenarios with both peripheral tumors and enlarged mediastinal lymph nodes, using ENB for navigation to both sites during the same session is justifiable. Nonetheless, ENB competes with alternative techniques, like tomosynthesis and robotics [28], and its future role, especially in the lung periphery, remains to be determined [29].…”

Section: Discussionmentioning

confidence: 99%

Navigated ultrasound bronchoscopy with integrated positron emission tomography - A human feasibility study

Kildahl-Andersen,

Hofstad,

Solberg

et al. 2024

Preprint

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Background and objectivePatients suspected to have lung cancer, undergo endobronchial ultrasound bronchoscopy (EBUS) for the purpose of diagnosis and staging. For presumptive curable patients, the EBUS bronchoscopy is planned based on images and data from computed tomography (CT) images and positron emission tomography (PET). Our study aimed to evaluate the feasibility of a multimodal electromagnetic navigation platform for EBUS bronchoscopy, integrating ultrasound and segmented CT, and PET scan imaging data.MethodsThe proof-of-concept study included patients with suspected lung cancer and pathological mediastinal/hilar lymph nodes identified on both CT and PET scans. Images obtained from these two modalities were segmented to delineate target lymph nodes and then incorporated into the CustusX navigation platform. The EBUS bronchoscope was equipped with a sensor, calibrated, and affixed to a 3D printed click-on device positioned at the bronchoscope’s tip. Navigation accuracy was measured postoperatively using ultrasound recordings.ResultsThe study enrolled three patients, all presenting with suspected mediastinal lymph node metastasis (N1-3). All PET-positive lymph nodes were displayed in the navigation platform during the EBUS procedures. In total, five distinct lymph nodes were sampled, yielding malignant cells from three nodes and lymphocytes from the remaining two. The median accuracy of the navigation system was 7.7 mm.ConclusionOur study introduces a feasible multimodal electromagnetic navigation platform that combines intraoperative ultrasound with preoperative segmented CT and PET imaging data for EBUS lymph node staging examinations. This innovative approach holds promise for enhancing the accuracy and effectiveness of EBUS procedures.

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“…In the past five years all efforts are directed to early disease diagnosis by performing low-dose computed tomography scans with intravenous contrast administration in high risk patients for lung cancer [1]. We can use the radial endobronchial ultrasound or an electromagnetic navigation system for diagnosis of pulmonary nodules or lung cancer lesions [2,3]. We can also use the rapid on site technique (ROSE) in order to assess Ivyspring International Publisher our sample as a method of fast diagnosis and evaluation of our sample [4].…”

Section: Introductionmentioning

confidence: 99%

Cryo-Biopsy versus 19G needle versus 22G needle with EBUS-TBNA endoscopy

Oikonomidou¹,

Petridis²,

Kosmıdis³

et al. 2022

J. Cancer

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Introduction:We have been using cryo-biopsy for endobronchial lesions for lung cancer diagnosis and debulking. Cryo-biopsy is also known to be an excellent tool for diagnosis of lung interstitial disease. Recently cryo-biopsy with the 1.1mm probe was used for lymphnode biopsy. Patients and Methods: 311 patients participated with lymphadenopathy and at least one lung lesion. The following tools were used for diagnosis; 22G Mediglobe Sonotip, 22G Medigolbe, 21G Olympus, 19G Olympus and 1.1mm cryo probe ERBE CRYO 2 system (3 seconds froze). A PENTAX Convex-probe EBUS was used for biopsy guidance. Results: Cell-blocks slices had a higher number in the 19G needle group (19G> Cryo Probe>22G Mediglobe Sonotip >21G Olympus >22G Mediglobe). Conclusion: Cryo biopsy of the lymphnodes is safe with the 1.1mm cryo probe. Further studies are needed in order to evaluate new probes and the technique specifications.

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What is the value of electromagnetic navigation in lung cancer and to what extent does it require improvement?

Cited by 8 publications

References 72 publications

Diagnostic outcomes of radial endobronchial ultrasound bronchoscopy guided by manual navigation in the evaluation of peripheral pulmonary lesions: An observational study

Diagnostic outcomes of radial endobronchial ultrasound bronchoscopy guided by manual navigation in the evaluation of peripheral pulmonary lesions: An observational study

Navigated ultrasound bronchoscopy with integrated positron emission tomography - A human feasibility study

Cryo-Biopsy versus 19G needle versus 22G needle with EBUS-TBNA endoscopy

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