What Is Your Diagnosis?

Lambert, Ruth J; Levin, Garrett; Wendelburg, Kirk L.; Huber, M.; Amann, J.A.; Bilbrey, Stephen A.

doi:10.2460/javma.229.6.931

Cited by 3 publications

(6 citation statements)

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“…The presumed pathogenesis of cryptococcal osteomyelitis is via hematogenous spread after pulmonary infection or, more rarely, via direct inoculation of the organism through the skin. 1,3 In the dog of the present report, no signs of systemic disease were evident; because the dog lived in the countryside, direct inoculation from an external wound was suspected. The radiologic appearance of cryptococcal osteomyelitis usually includes lytic lesions associated with soft tissue swelling, 2,4 as in this case.…”

Section: Commentsmentioning

confidence: 52%

“…Other organ systems such as the CNS are much more commonly affected in dogs. 1 However, to the author's knowledge, this is the first reported case of cryptococcal patellar osteomyelitis in a dog. The presumed pathogenesis of cryptococcal osteomyelitis is via hematogenous spread after pulmonary infection or, more rarely, via direct inoculation of the organism through the skin.…”

Section: Commentsmentioning

confidence: 75%

“…4 However, cytologic and serologic examination and histopathologic findings are required for a final diagnosis of cryptococ-cosis. 1 Cryptococcosis should be considered in the differential diagnosis of an osteolytic patellar lesion.…”

Section: Commentsmentioning

confidence: 99%

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What Is Your Diagnosis?

Agut

Boza²,

Murciano³

et al. 2013

javma

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HistoryA 5-year-old 36-kg (79.2-lb) sexually intact male German Shepherd Dog was evaluated because of mild lameness of the right hind limb of 15 days' duration, without previous history of trauma. On physical examination, the thigh muscles were atrophied, and swelling of the right stifle joint was evident. Signs of pain were elicited on palpation of this area. The rest of the examination findings were unremarkable.Results of hematologic and biochemical analyses were within reference ranges. Radiographs of the right stifle joint were obtained (Figure 1).Determine whether additional imaging studies are required, or make your diagnosis from Figure 1-then turn the page →

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Section: Commentsmentioning

confidence: 52%

Section: Commentsmentioning

confidence: 75%

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What Is Your Diagnosis?

Agut

Boza²,

Murciano³

et al. 2013

javma

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“…1,2,6,11,12 The most frequent clinical manifestation of feline cryptococcosis is associated with the nasal form, but the disease can occur in several other distinct clinical forms, with involvement of the central nervous system (CNS), ocular, cutaneous, lymph nodes, and even pulmonary, abdominal and periarticular connective tissues. 3,4 Ocular lesions are a common manifestation of systemic cryptococcosis (observed in about one-third of clinical cases), primarily manifesting as multifocal chorioretinitis. 1,13 A definitive diagnosis of cryptococcosis can be established using cytological examination, serology for the detection of antibodies (cryptococcal antigen latex agglutination test), fungal culture, histopathology and PCR.…”

Section: Blepharitis Due To Cryptococcus Neoformans In a Cat From Normentioning

confidence: 99%

“…Cryptococcosis is the most common systemic fungal disease in cats worldwide. 1–4 Infections with Cryptococcus species may also occur in several other mammalian species, including dogs and humans, and even in birds and reptiles. 1,5 Feline cryptococcosis is caused by basidiomycetous encapsulated yeasts of the genus Cryptococcus (Tremellomycetes: Tremellaceae) belonging to the Cryptococcus neoformans–Cryptococcus gattii complex.…”

Section: Introductionmentioning

confidence: 99%

Blepharitis due to Cryptococcus neoformans in a cat from northern Portugal

Pimenta

Alves‐Pimenta

Barros

et al. 2015

Journal of Feline Medicine and Surgery Open Reports

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Case summary We report a clinical case of blepharitis due to Cryptococcus neoformans yeasts in a 2-year-old stray cat from northern Portugal (Vila Real) without concurrent naso-ocular signs. Ophthalmological examination revealed mucopurulent discharge from an open wound in the right upper and lower lids. Slit-lamp biomicroscopy showed a normal anterior segment, and intraocular pressure was within the normal reference interval. No fundoscopic alterations were detected in either eye by direct and indirect ophthalmoscopic examination. Cytological examination of an appositional smear showed numerous polymorphic neutrophils and macrophages, together with spherical yeast cells compatible with Cryptococcus species. Molecular analysis by means of PCR and restriction fragment length polymorphism identified C neoformans genotype VNI. The cat was treated with itraconazole, and amoxicillin and clavulanic acid, combined with a commercial ear ointment and an imidacloprid/moxidectin spot-on application for bilateral parasitic otitis caused by Otodectes cynotis. One month after treatment, the clinical signs were completely resolved. Localised cutaneous lesions, as in the present case, probably result from contamination of cat-scratch injuries with viable encapsulated yeasts.Relevance and novel information This is, to the best of our knowledge, the first clinical report of feline blepharitis due to C neoformans without concurrent naso-ocular signs. The current findings, together with those from recent reports of the infection in domestic animals, should alert the veterinary community both in Portugal and in Europe to this underdiagnosed disease.

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