Continuous technological development, digitalization, Industry 4.0, robotization, virtualization, and related investments in new types of physical assets are imposing increasing financial and intellectual demands on micro, small, and medium-sized enterprises (MSMEs). While fast technological development and rapid societal change make maintenance of a successful competitive edge ever more challenging, they also offer considerable potential for differentiation. In the area of networking and outside resources, MSMEs can utilize external resources and cooperate and collaborate with higher educational institutions (HEI) to boost their innovations pipeline and develop new technologies and processes to generate commercial products/services and improve their service offering. This research explores existing highly effective university–industry collaboration (UIC) models and seeks explanations for their success by examining the literature from the point of view of establishing successful relationships, emphasizing the importance of critical drivers for success. Our work synthesizes current knowledge of best practices based on a comparative analysis of practical collaboration. In the work, we identify eight popular and successful collaboration models: research and development partnerships, internships and co-op programs, knowledge transfer programs, entrepreneurship, and incubation programs, sponsored projects and grants, joint ventures and licensing agreements, executive education, professional and student career development. Based on analysis of globally reviewed successful models, a concept for robust, productive, and extended collaboration between companies and universities is produced suitable for the Finnish context. Several practical experiences are given for robust collaboration in the current post-COVID transition and energy crisis.