What magnetic resonance imaging reveals – A systematic review of the relationship between type II diabetes and associated brain distortions of structure and cognitive functioning

Rosenberg, Jessica; Lechea, Nazim; Pentang, Gael; Shah, N. Jon

doi:10.1016/j.yfrne.2018.10.001

Cited by 32 publications

(35 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diabetes is characterized by multiple mutagenic events that affect the secretion and sensitivity of insulin. Moreover, diabetes is known to be associated with various diseases in different tissues and organs, including kidney, skeleton muscle, eyes, lung, heart, liver, and even brain [142,143,144,145,146,147,148]. The protein Cdc42 is a member of the Rho family of small GTPases.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases

Huang

Lai

Qian

et al. 2019

IJMS

View full text Add to dashboard Cite

Cdc42, a member of the Rho GTPases family, is involved in the regulation of several cellular functions including cell cycle progression, survival, transcription, actin cytoskeleton organization and membrane trafficking. Diabetes is a chronic and metabolic disease, characterized as glycometabolism disorder induced by insulin deficiency related to β cell dysfunction and peripheral insulin resistance (IR). Diabetes could cause many complications including diabetic nephropathy (DN), diabetic retinopathy and diabetic foot. Furthermore, hyperglycemia can promote tumor progression and increase the risk of malignant cancers. In this review, we summarized the regulation of Cdc42 in insulin secretion and diabetes-associated diseases. Organized researches indicate that Cdc42 is a crucial member during the progression of diabetes, and Cdc42 not only participates in the process of insulin synthesis but also regulates the insulin granule mobilization and cell membrane exocytosis via activating a series of downstream factors. Besides, several studies have demonstrated Cdc42 as participating in the pathogenesis of IR and DN and even contributing to promote cancer cell proliferation, survival, invasion, migration, and metastasis under hyperglycemia. Through the current review, we hope to cast light on the mechanism of Cdc42 in diabetes and associated diseases and provide new ideas for clinical diagnosis, treatment, and prevention.

show abstract

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases

Huang

Lai

Qian

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…The brain, as one of the most sophisticated organ in our body [11], plays an important role in glucose homeostasis by producing adaptive changes in energy intake, energy consumption, and hepatic glucose production [12]. Many cerebral-related injuries, disorders or dysfunctions can lead to irreparably serious consequences.…”

Section: Introductionmentioning

confidence: 99%

Potential Biochemical Mechanisms of Brain Injury in Diabetes Mellitus

Xing¹,

Tang²,

Lei³

et al. 2020

Aging and disease

View full text Add to dashboard Cite

The goal of this review was to summarize current biochemical mechanisms of and risk factors for diabetic brain injury. We mainly summarized mechanisms published in the past three years and focused on diabetes induced cognitive impairment, diabetes-linked Alzheimer's disease, and diabetic stroke. We think there is a need to conduct further studies with increased sample sizes and prolonged period of follow-ups to clarify the effect of DM on brain dysfunction. Additionally, we also think that enhancing experimental reproducibility using animal models in conjunction with application of advanced devices should be considered when new experiments are designed. It is expected that further investigation of the underlying mechanisms of diabetic cognitive impairment will provide novel insights into therapeutic approaches for ameliorating diabetes-associated injury in the brain.

show abstract

“…1.02;2.29 and 1.49, 1.02;2.18, respectively). People with pre-diabetes, undiagnosed and known diabetes had higher WMH volumes (4%, 30%, 3%, respectively), and lower HV (34.51 mm 3 , 11.73 mm 3 and 61.13 mm 3 respectively). People with low-normal HbA 1c (<35 mmol/mol) had 5% lower WMH volume and 13.6 mm 3 greater HV than normoglycaemic individuals.…”

mentioning

confidence: 98%

“…Type-2 diabetes and, more generally, hyperglycaemic states, have been associated with poorer cognitive function (such as learning and memory)(1), increased risk of dementia (2) and alterations in key brain structures, particularly the hippocampus (3). In contrast, recent evidence from a randomised crossover trial also suggests that, in people with diabetes, even modest hypoglycaemia has a detrimental effect on cognitive function (4).…”

mentioning

confidence: 99%

Is glycaemia associated with poorer brain health and risk of dementia? Cross sectional and follow-up analysis of the UK Biobank

Garfield

Farmaki

Eastwood

et al. 2020

Preprint

View full text Add to dashboard Cite

INTRODUCTION: To understand the relationship across the glycaemic spectrum, with brain health. METHODS: UK Biobank participants. HbA1c and diabetes diagnosis define baseline glycaemic categories. Outcomes: incident vascular dementia (VD), Alzheimer′s dementia (AD), hippocampal volume (HV), white matter hyperintensity (WMH) volume, cognitive function and decline. Reference group: normoglycaemic individuals (HbA1c 35-<42 mmol/mol). RESULTS: Pre- and known diabetes increased incident VD, (HR 1.54, 95%CI=1.04;2.28 and 2.97, 95%CI=2.26;3.90). Known diabetes increased AD risk (HR 1.84, 95%CI=1.44;2.36). Pre- and known diabetes elevated risks of cognitive decline (OR 1.42, 1.48;2.96 and 1.39, 1.04;1.75). Pre-diabetes, undiagnosed and known diabetes conferred higher WMH volumes (4%, 26%, 5%,) and lower HV (22.4mm3, 15.2mm3, 62.2mm3). Low-normal HbA1c had 2% lower WMH volume and 13.6mm3 greater HV. DISCUSSION: Pre and known diabetes increase VD risks; known diabetes increases AD risk. Low-normal HbA1c associates with favourable neuroimaging outcomes. Our findings may have implications for cardiovascular medication in hyperglycaemia for brain health.

show abstract

What magnetic resonance imaging reveals – A systematic review of the relationship between type II diabetes and associated brain distortions of structure and cognitive functioning

Cited by 32 publications

References 80 publications

Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases

Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases

Potential Biochemical Mechanisms of Brain Injury in Diabetes Mellitus

Is glycaemia associated with poorer brain health and risk of dementia? Cross sectional and follow-up analysis of the UK Biobank

Contact Info

Product

Resources

About