What might cervical vestibular–evoked myogenic potential abnormalities mean in essential tremor?

Uyaroğlu, Feray Güleç; Ucar, Roza; Acarer, Ahmet; Çelebisoy, Neşe

doi:10.1007/s10072-021-05248-5

Cited by 5 publications

(5 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Essential tremor is known to affect balance function. Studies have revealed impairment in vestibulo-ocular reflex, vestibulo-colic reflex, and overall balance impairments in patients with essential tremor [13][14][15][16]. Consistent with previous literature our experiments found impairment in vestibular heading perception in isolated CD, CD with tremor, and isolated tremor.…”

Section: Discussionsupporting

confidence: 92%

“…Cervical vestibular-evoked myogenic potentials and ocular vestibularevoked myogenic potentials -examining the vestibulo-collic and vestibulo-ocular reflex have increased amplitude but shortened latency in essential tremor compared to healthy controls [13]. Abnormal vestibulo-colic reflex in essential tremor suggests putative dysfunction in regions that process central vestibular information, such as the cerebellum [14]. Balance dysfunction is commonly seen in cerebellar predominant form of essential tremor where action tremor is much more robust, and it is often associated with dysarthria in this subset of patients [15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exploring Heading Direction Perception in Cervical Dystonia, Tremor, and Their Coexistence

Guha,

Agharazi,

Gupta

et al. 2023

Preprint

View full text Add to dashboard Cite

Dystonias, characterized by excessive muscle contractions resulting in involuntary postures and movements, impact 3 million people globally, making them the third most common movement disorder. Often accompanied by tremors, dystonias have epidemiological links and non-motor features shared with isolated tremor, such as essential tremor. Both dystonia and tremor present with balance dysfunction and abnormal involuntary movements, potentially linked to abnormal cerebellar function. This study explores the perception of one’s own linear movement, heading, particularly discrimination of heading direction, in isolated cervical dystonia, isolated tremor, and their combination. The focus is on the perception of heading direction during isolated visual star-cloud movement (visual heading perception) and en bloc body movement (vestibular heading perception). Nineteen participants underwent a two-alternative forced-choice task in the vestibular and visual domains. Results reveal elevated vestibular heading perception thresholds in cervical dystonia with or without tremor, and isolated tremor compared to healthy controls. Vestibular heading perception threshold was comparable in cervical dystonia with tremor and isolated tremor, but it was even worse in isolated cervical dystonia. Visual heading perception, however, remained less affected all three conditions – isolated cervical dystonia, isolated tremor, and their combination. These findings indicate shared deficits and distinctions in the perception of linear translational heading across movement disorders, such as isolated cervical dystonia, tremor, or their combination, offering insights into their pathophysiology, particularly the involvement of cerebellum regions responsible for vestibular processing.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Exploring Heading Direction Perception in Cervical Dystonia, Tremor, and Their Coexistence

Guha,

Agharazi,

Gupta

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Essential tremor is known to affect balance function. Studies have revealed impairment in vestibulo-ocular reflex, vestibulo-collic reflex, and overall balance impairments in patients with essential tremor [ 13 , 14 , 15 , 16 ]. Consistent with previous literature our experiments found impairment in vestibular heading perception in isolated CD, CD with tremor, and isolated tremor.…”

Section: Discussionmentioning

confidence: 99%

“…Cervical vestibular-evoked myogenic potentials and ocular vestibular-evoked myogenic potentials—examining the vestibulo-collic and vestibulo-ocular reflex have increased amplitude but shortened latency in essential tremor compared to healthy controls [ 13 ]. Abnormal vestibulo-collic reflex in essential tremor suggests putative dysfunction in regions that process central vestibular information, such as the cerebellum [ 14 ]. Balance dysfunction is commonly seen in cerebellar predominant form of essential tremor where action tremor is much more robust, and it is often associated with dysarthria in this subset of patients [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring Heading Direction Perception in Cervical Dystonia, Tremor, and Their Coexistence

Guha,

Agharazi,

Gupta

et al. 2024

Brain Sciences

View full text Add to dashboard Cite

Objective: Dystonias, characterized by excessive muscle contractions resulting in involuntary postures and movements, impact 3 million people globally, making them the third most common movement disorder. Often accompanied by tremors, dystonias have epidemiological links and non-motor features shared with isolated tremor, such as essential tremor. Both dystonia and tremor present with balance dysfunction and abnormal involuntary movements, potentially linked to abnormal cerebellar function. This study explores the perception of one’s own linear movement, heading, particularly discrimination of heading direction, in isolated cervical dystonia, isolated tremor, and their combination. We compare such perception behavior in visual and vestibular domains, predicting that visual heading perception would be superior to vestibular heading perception. Methods: Following the focus on the perception of heading direction, we used psychophysics techniques, such as two-alternative-forced-choice task, to examine perception of direction of one’s own movements as they see isolated visual star-cloud movement (visual heading perception) and en bloc body movement (vestibular heading perception). We fitted a sigmoidal psychometric function curve to determine the threshold for visual or vestibular heading perception in our participants. Results: Nineteen participants underwent a two-alternative forced-choice task in the vestibular and visual domains. Results reveal elevated vestibular heading perception thresholds in cervical dystonia with or without tremor, and isolated tremor compared to healthy controls. Vestibular heading perception threshold was comparable in cervical dystonia with tremor and isolated tremor, but it was even worse in isolated cervical dystonia. Visual heading perception, however, remained less affected all three conditions—isolated cervical dystonia, isolated tremor, and their combination. Conclusion: These findings indicate shared deficits and distinctions in the perception of linear translational heading across movement disorders, such as isolated cervical dystonia, tremor, or their combination, offering insights into their pathophysiology, particularly the involvement of cerebellum regions responsible for vestibular processing.

show abstract

“…A more significant number of patients, more long-term follow-up, and more detailed vestibular evaluation are likely to be warranted to confirm our observations. Seventh, it can be argued that the posture in PD could affect VEMP findings [ 16 , 17 , 18 ] because PD patients usually have abnormal posture such as stooped or bent. Although we did not perform detailed objective measurements for posture, the item 28 score (i.e., posture) between PD without PI and with PI was similar.…”

Section: Discussionmentioning

confidence: 99%

Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease

Park

Kim

Kang

2022

JCM

View full text Add to dashboard Cite

Backgrounds: We aimed to understand the association between initial vestibular function examination and postural instability (PI) development in Parkinson’s disease (PD). Methods: After screening 51 PD patients, we divided 31 patients into 2 groups based on the presence of PI at the follow-up visit and compared the clinical features and vestibular-evoked myogenic potential (VEMP) variables. Results: The mean values of Hoehn and Yahr stage, Unified Parkinson’s Disease Rating Scale (UPDRS) part III, and item 30 (postural stability) of UPDRS were larger in patients with PI at a follow-up visit (p = 0.000, 0.006, 0.048, respectively). In VEMP analyses, the onset latencies of left and right cervical VEMPs were significantly reduced in patients with PI (p = 0.013, 0.040, respectively). Conclusion: We found that the initial VEMP test may be associated with later postural imbalance in PD, suggesting the baseline evaluation may help predict future PI occurrence. A more significant number of patients and more long-term follow-ups are likely to be required for confirmation.

show abstract

What might cervical vestibular–evoked myogenic potential abnormalities mean in essential tremor?

Cited by 5 publications

References 35 publications

Exploring Heading Direction Perception in Cervical Dystonia, Tremor, and Their Coexistence

Exploring Heading Direction Perception in Cervical Dystonia, Tremor, and Their Coexistence

Exploring Heading Direction Perception in Cervical Dystonia, Tremor, and Their Coexistence

Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease

Contact Info

Product

Resources

About