What psychological process is reflected in the FN400 event-related potential component?

Leynes, P. Andrew; Bruett, Heather; Krizan, Jenna; Veloso, Ana

doi:10.1016/j.bandc.2017.02.004

Cited by 45 publications

(32 citation statements)

References 33 publications

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“…Interestingly, we identified a reduced amplitude for all pairs in the ASD group relative to TD group. Given that the FN400 potential reflects both conceptual priming and familiarity during episodic recognition [see review and recent account in Leynes et al, 2017], this amplitude decrement in the ASD group may correspond to reduced semantic processing and familiarity signal elicited by pictures within a pair. Consistent with this account, Solomon et al [2016] identified during the recognition of picture pairs after relational encoding a reduced level of familiarity awareness in their adolescent participants with ASD relative to those without ASD.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, the FN400 old/new effect can be elicited by the recognition of single items, as well as items unitized into a single‐item representation [e.g., Rhodes & Donaldson, 2007]. This FN400 potential may reflect semantic processing during recognition testing [e.g., Voss & Federmeier, 2011], or be a specific marker of familiarity‐based recognition [e.g., Bridger, Bader, Kriukova, Unger, & Mecklinger, 2012; Stróżak, Abedzadeh, & Curran, 2016], more recent paradigms leading to a mixed model [Leynes, Bruett, Krizan, & Veloso, 2017]. Consistently, the recollective nature of the LPC old/new effect has been confirmed during recollection awareness [e.g., Wynn, Daselaar, Kessels, & Schutter, 2019], source memory [e.g., Addante, Ranganath, & Yonelinas, 2012], associative recognition [e.g., Borst, Ghuman, & Anderson, 2016; Opitz & Cornell, 2006], and simultaneous EEG–fMRI recordings identified posterior hippocampal and parahippocampal generators—areas being related to the episodic memory system [Hoppstädter, Baeuchl, Diener, Flor, & Meyer, 2015].…”

Section: Introductionmentioning

confidence: 99%

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Exploring the Event‐Related Potentials' Time Course of Associative Recognition in Autism

et al. 2020

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Behavioral data on episodic recollection in autism spectrum disorders (ASD) point limited relational memory functioning. However, the involvement of successive memory processes in the profile of episodic memory in ASD needs more study. Here, we used event-related potentials (ERP) to investigate the time course of episodic recollection with an associative recognition paradigm with picture pairs. Twenty-two participants with ASD and 32 with typical development (TD), all right-handed, were included. Behavioral results confirmed difficulties in correctly recognizing identical pairs in the ASD relative to TD group. We found an unexpected amplitude decrement on the P2 (220-270 msec) and FN400 (350-470 msec) potentials, suggesting diminished priming and familiarity effects in the ASD relative to TD group. However, ERP data revealed that the recognition of associative information relies on the same electrophysiological process (old/new effect in the 600-700-msec late positive component) in ASD participants as in TD ones, with a parietal extension in the ASD group. These results suggest that the electrophysiological processes of associative recognition are qualitatively similar in individuals with and without ASD but may differ quantitatively. This difference may be driven by the reduced early processing of picture pairs that may in turn lead to their diminished integration into the semantic memory system, being partially compensated by a greater involvement of associative memory during the recollection process. Other studies would be useful to go further in identifying these cognitive processes involved in atypical recognition in ASD and their neural substrates.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring the Event‐Related Potentials' Time Course of Associative Recognition in Autism

et al. 2020

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“…The change in the N400 amplitude related to incongruent information at study could then lead to a greater ERP old/new effect at test. Thus, incongruity at encoding may lead to a fluency‐based response at test, and this “pop‐out” effect could be reflected at recognition time (see also Leynes, Bruett, Krizan, & Veloso, ). This encoding integration effect during recognition has been attributed to automatic object‐context binding (Hayes, Nadel, & Ryan, ).…”

Section: Discussionmentioning

confidence: 99%

An ERP investigation of item‐scene incongruity at encoding on subsequent recognition

2020

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The aim of the present study was to investigate how item‐scene incongruity at encoding influences subsequent item recognition and the associated event‐related potential (ERP) old/new effects. Participants (N = 26) studied pictures showing an item in a scene, either in a congruent condition (e.g., a tent in a field) or an incongruent condition (e.g., a shower cabin in a field). Items were presented alone at test. Behavioral data revealed a benefit of incongruent information, with greater source memory performance but no significant effect on old/new recognition judgments. Longer response times for old compared to new items showed that participants not only evaluated the old‐new status of objects during recognition, but also worked already on the scene context decision relative to the source memory judgment. An ERP incongruity effect was found at study, with greater N400 amplitude in the incongruent condition than the congruent condition. During recognition, the results provide evidence that item‐scene incongruity at study increases the amplitude of ERP old/new effects. A mid‐frontal N400 old/new effect was found in the early time window (300–500 ms), and a right frontal sub‐component was modulated by item‐scene incongruity at encoding. The modulation observed in the later time window (500–800 ms) confirmed previous studies showing that the parietal old/new effect reflects the retrieval of episodic contextual details. The present study shows that the magnitude of ERP old/new effects is sensitive to item‐scene incongruity at encoding from the early time window in the right frontal region to the later retrieval processes.

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“…For example, N400 amplitude has an inverse relationship with semantic priming, in which novel stimuli tend to elicit larger amplitudes than primed stimuli [i.e., priming effect; [48]. All three of these studies specifically assessed N400 amplitude at frontal electrodes (i.e., frontal N400, FN400), which has been suggested to index familiarity and conceptual implicit memory [32,80], with others suggesting [71,126], while the other used picture-name congruity [42]. Although there is some inconsistency in this small literature, particularly with different tasks and methods of calculating N400 metrics, N400 amplitude nevertheless appears to differentiate between AD and HC more consistently (76%) than N200 (18%) and P300 (60%) amplitudes.…”

Section: N400mentioning

confidence: 99%

A systematic review of cognitive event-related potentials in mild cognitive impairment and Alzheimer’s disease

Paitel

Samii

Nielson

2021

Behavioural Brain Research

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This systematic review examined whether event-related potentials (ERPs) during higher cognitive processing can detect subtle, early signs of neurodegenerative disease. Original, empirical studies retrieved from PsycINFO and PubMed were reviewed if they analyzed patterns in cognitive ERPs (³150ms post-stimulus) differentiating mild cognitive impairment (MCI), Alzheimer's disease (AD), or cognitively intact elders who carry AD risk through the Apolipoprotein-E ε4 allele (ε4+) from healthy older adult controls (HC). The 100 studies meeting inclusion criteria (MCI=47; AD=47; ε4+=6) analyzed N200, P300, N400, and occasionally, later components. While there was variability across studies, patterns of reduced amplitude and delayed latency were apparent in pathological aging, consistent with AD-related brain atrophy and cognitive impairment. These effects were particularly evident in advanced disease progression (i.e., AD > MCI) and in later ERP components measured during complex tasks. Although ERP studies in intact ε4+ elders are thus far scarce, a similar pattern of delayed latency was notable, along with a contrasting pattern of increased amplitude, consistent with compensatory neural activation. This limited work suggests ERPs might be able to index early neural changes indicative of future cognitive decline in otherwise healthy elders. As ERPs are also accessible and affordable relative to other neuroimaging methods, their addition to cognitive assessment might substantively enhance early identification and characterization of neural dysfunction, allowing opportunity for earlier differential diagnosis and targeting of intervention. To evaluate this possibility there is urgent need for well-powered studies assessing late cognitive ERPs during complex tasks, particularly in healthy elders at risk for cognitive decline.

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What psychological process is reflected in the FN400 event-related potential component?

Cited by 45 publications

References 33 publications

Exploring the Event‐Related Potentials' Time Course of Associative Recognition in Autism

Exploring the Event‐Related Potentials' Time Course of Associative Recognition in Autism

An ERP investigation of item‐scene incongruity at encoding on subsequent recognition

A systematic review of cognitive event-related potentials in mild cognitive impairment and Alzheimer’s disease

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