What Remains up to 7 Months after Severe and Moderate Pneumonia in Non-Vaccinated Patients with Long COVID? Results of a CT Study

Kurys-Denis, Ewa; Grzywa-Celińska, Anna; Podgórska, Katarzyna; Kawa, Miłosz Piotr

doi:10.3390/jcm12165388

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Actually, GGOs are described in 80% of the patients during the acute phase [ 44 ], and persist later among other radiological abnormalities [ 45 , 46 ]. Control CTs after a COVID-19 infection show GGOs in 49% at 3 months [ 47 ], a decrease of the prevalence at 5 to 7 months [ 47 – 50 ], reaching 24% at 1 year [ 49 , 51 , 52 ] and 11% at 18 months [ 48 , 51 – 54 ]. It is unclear how long the radiological clearance takes [ 55 ].…”

Section: The Ongoing Challenge Of Ground-glass Opacities In the Lungmentioning

confidence: 99%

ERS International Congress 2023: highlights from the Thoracic Oncology Assembly

Catarata,

Creamer,

Dias

et al. 2023

ERJ Open Res

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Lung cancer is the leading cause of cancer mortality in the world. It greatly affects the patients’ quality of life, being a challenge for the daily practice in Respiratory Medicine. Advances in the genetic knowledge of thoracic tumours mutational landscape, the development of targeted therapies and immune checkpoint inhibitors, led to a paradigm shift in the treatment of lung cancer and pleural mesothelioma. During the annual ERS Congress in Milan, Italy, experts from all over the world presented their high-quality research and reviewed best clinical practices. Lung cancer screening, management of early-stages of lung cancer, application of artificial intelligence and biomarkers were discussed and they will be summarised here.

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Section: The Ongoing Challenge Of Ground-glass Opacities In the Lungmentioning

confidence: 99%

ERS International Congress 2023: highlights from the Thoracic Oncology Assembly

Catarata,

Creamer,

Dias

et al. 2023

ERJ Open Res

View full text Add to dashboard Cite

show abstract

Comparative Transcriptomic Analyses of Peripheral Blood Mononuclear Cells of COVID-19 Patients without Pneumonia and with Severe Pneumonia in the First Year of Follow-Up

Kayalar,

Cetinkaya,

Eldem

et al. 2024

Viruses

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The multisystemic effects of COVID-19 may continue for a longer time period following the acute phase, depending on the severity of the disease. However, long-term systemic transcriptomic changes associated with COVID-19 disease and the impact of disease severity are not fully understood. We aimed to investigate the impact of COVID-19 and its severity on transcriptomic alterations in peripheral blood mononuclear cells (PBMCs) following 1 year of the disease. PBMCs were isolated from the peripheral blood of healthy control donors who did not have COVID-19 (C; n = 13), from COVID-19 patients without pneumonia (NP; n = 11), and from COVID-19 patients with severe pneumonia (SP; n = 10) after 1-year of follow-up. Following RNA isolation from PBMCs, high-quality RNAs were sequenced after creating a library. Differentially expressed genes (DEGs) and differentially expressed long non-coding RNAs (DElncRNAs) were identified using Benjamini–Hochberg correction and they were analysed for hierarchical clustering and principal component analysis (PCA). Intergroup comparisons (C vs. NP, C vs. SP, and NP vs. SP) of DEGs and DElncRNAs were performed and hub genes were determined. Functional enrichment analyses of DEGs and DElncRNAs were made using Metascape (v3.5.20240101) and the first version of NCPATH. The RNA sequencing analysis revealed 4843 DEGs and 1056 DElncRNAs in “C vs. NP”, 1651 DEGs and 577 DElncRNAs in “C vs. SP”, and 954 DEGs and 148 DElncRNAs in “NP vs. SP”, with 291 DEGs and 70 DElncRNAs shared across all groups, respectively. We identified 14 hub genes from 291 DEGs, with functional enrichment analysis showing upregulated DEGs mainly linked to inflammation and osteoclast differentiation and downregulated DEGs to viral infections and immune responses. The analysis showed that 291 common and 14 hub genes were associated with pneumonia and that these genes could be regulated by the transcription factors JUN and NFκB1 carrying the NFκB binding site. We also revealed unique immune cell signatures across DEG categories indicating that the upregulated DEGs were associated with neutrophils and monocytes, while downregulated DEGs were associated with CD4 memory effector T cells. The comparative transcriptomic analysis of NP and SP groups with 52 gene signatures suggestive of IPF risk showed a lower risk of IPF in the SP group than the NP patients. Our findings suggest that COVID-19 may cause long term pathologies by modulating the expression of various DEGs, DeLncRNAs, and hub genes at the cellular level.

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What Remains up to 7 Months after Severe and Moderate Pneumonia in Non-Vaccinated Patients with Long COVID? Results of a CT Study

Cited by 2 publications

References 23 publications

ERS International Congress 2023: highlights from the Thoracic Oncology Assembly

ERS International Congress 2023: highlights from the Thoracic Oncology Assembly

Comparative Transcriptomic Analyses of Peripheral Blood Mononuclear Cells of COVID-19 Patients without Pneumonia and with Severe Pneumonia in the First Year of Follow-Up

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