What’s New in the Molecular Diagnosis of Childhood Tuberculosis?

Shaikh, Ambreen; Rodrigues, Camilla

doi:10.1097/inf.0000000000004044

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…In recent years there have been several important advances in TB diagnostics with implications for the approach to microbiologic confirmation and detection of resistance in children [17] . The current recommendation from the WHO is to use Xpert MTB/RIF or Xpert MTB/RIF Ultra as the initial diagnostic test for TB detection and identification of rifampin resistance in sputum specimens, in place of conventional approaches such as microscopy and culture-based DST [18] .…”

Section: Diagnostic Considerations For Pediatric Drug-resistant Tuber...mentioning

confidence: 99%

Multidrug-resistant tuberculosis in children: A practical update on epidemiology, diagnosis, treatment and prevention

Gaensbauer,

Dash,

Verma

et al. 2024

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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Section: Diagnostic Considerations For Pediatric Drug-resistant Tuber...mentioning

confidence: 99%

Multidrug-resistant tuberculosis in children: A practical update on epidemiology, diagnosis, treatment and prevention

Gaensbauer,

Dash,

Verma

et al. 2024

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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Diagnosis of acute Q fever using targeted next‑generation sequencing: A case report

Jiang,

Yan,

Yang

et al. 2024

Exp Ther Med

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Acute Q fever, caused by Coxiella burnetii , is a zoonotic infection presenting with non-specific symptoms such as high fever, severe headache and myalgia, making it challenging to diagnose. Traditional diagnostic methods often fall short due to their time-consuming nature and limited sensitivity. A 26-year-old male presented with severe headache, persistent high fever and nausea following a hiking trip. Initial tests, including serology and PCR, were inconclusive. Targeted next-generation sequencing (tNGS) identified C. burnetii within 24 h, leading to a prompt diagnosis of acute Q fever. This rapid identification facilitated the initiation of appropriate antibiotic therapy, resulting in significant clinical improvement. This case underscores the diagnostic utility of tNGS in rapidly identifying rare pathogens and highlights its potential to influence clinical decision-making and improve patient outcomes. This case highlights the effectiveness of tNGS in diagnosing acute Q fever, particularly in regions where the disease is uncommon. The use of tNGS facilitated rapid identification and treatment, underscoring its potential as a valuable diagnostic tool in clinical practice.

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Diagnostics for Tuberculosis

Kambli,

Rodrigues

2023

Journal of Clinical Infectious Disease Society

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Accurate diagnosis and treatment of Tuberculosis (TB) continues to elude us. To overcome this, detection of Mycobacterium tuberculosis (MTB) and testing for drug resistance is of paramount importance. Globally, only one in three patients are bacteriologically confirmed and just one in five is diagnosed with a WHO endorsed molecular test, emphasising that diagnostic gaps continue to preclude patients from accessing care. Therefore, it is essential that newer and affordable technologies for the detection of MTB in low and middle income countries (LMICs) reach that last mile. In this review we discuss various recent technologies for detection of active TB disease, that have the possibility of being considered, or are already WHO endorsed.

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What’s New in the Molecular Diagnosis of Childhood Tuberculosis?

Abstract: The ESPID Reports and Reviews of Pediatric Infectious Diseases series topics, authors and contents are chosen and approved independently by the Editorial Board of ESPID. CONTENTSWhat's New in the Molecular Diagnosis of Childhood Tuberculosis?

Cited by 3 publications

References 34 publications

Multidrug-resistant tuberculosis in children: A practical update on epidemiology, diagnosis, treatment and prevention

Multidrug-resistant tuberculosis in children: A practical update on epidemiology, diagnosis, treatment and prevention

Diagnosis of acute Q fever using targeted next‑generation sequencing: A case report

Diagnostics for Tuberculosis

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