What's new in wound treatment: a critical appraisal

Garwood, Caitlin S.; Steinberg, John S.

doi:10.1002/dmrr.2747

Cited by 32 publications

(22 citation statements)

References 53 publications

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“…1 Cellular and tissue-based treatments that can simultaneously modulate inflammation in the wound microenvironment and promote regenerative responses have recently become a focus of wound care therapy development. 2 In healthy skin, wound healing is divided into four integrated and tightly regulated phases: hemostasis, inflammation, proliferation, and tissue remodeling. 3 Immune cells infiltrate the wound in a specific and predictable order, with neutrophils and macrophages associated with the inflammation phase, and lymphocytes associated with the proliferation and remodeling phases.…”

mentioning

confidence: 99%

Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions

Sîrbulescu

Boehm

Soon

et al. 2017

Wound Repair Regeneration

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Chronic wounds affect 12–15% of patients with diabetes and are associated with a drastic decrease in their quality of life. Here we demonstrate that purified mature naïve B220+/CD19+/IgM+/IgD+ B cells improve healing of acute and diabetic murine wounds after a single topical application. B cell treatment significantly accelerated acute wound closure by 2–3 days in wild-type mice and 5–6 days in obese diabetic mice. The treatment led to full closure in 43% of chronic diabetic wounds, as compared to only 5% in saline-treated controls. Applying equivalent numbers of T cells or disrupted B cells failed to reproduce these effects, indicating that live B cells mediated pro-healing responses. Topically-applied B cell treatment was associated with significantly reduced scar size, increased collagen deposition and maturation, enhanced angiogenesis and increased nerve growth into and under the healing wound. β-III tubulin+ nerve endings in scars of wounds treated acutely with B cells showed increased relative expression of growth-associated protein 43. The improved healing associated with B cell treatment was supported by significantly increased fibroblast proliferation and decreased apoptosis in the wound bed and edges, altered kinetics of neutrophil infiltration, as well as an increase in TGF-β and a significant reduction in MMP2 expression in wound granulation tissue. Our findings indicate that the timeline and efficacy of wound healing can be experimentally manipulated through the direct application of mature, naive B cells, which effectively modify the balance of mature immune cell populations within the wound microenvironment and accelerate the healing process.

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mentioning

confidence: 99%

Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions

Sîrbulescu

Boehm

Soon

et al. 2017

Wound Repair Regeneration

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“…Many molecules that emerge during inflammation have adhesive properties. e amount of adhesion formation is related to the severity and duration of the inflammation [17,18]. In the second stage of wound healing, fibrinogen proteins turn into thin fibrin fibers.…”

Section: Discussionmentioning

confidence: 99%

Effects of Glycerol and Sodium Pentaborate Formulation on Prevention of Postoperative Peritoneal Adhesion Formation

Ayşan

Şahın

Catal

et al. 2020

Obstetrics and Gynecology International

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Background. Postoperative peritoneal adhesions (PPA) are a serious problem for abdominal surgery. An effective remedy has not been found yet. New formulation of glycerol and sodium pentaborate may be able to solve the problem. Method. Female Wistar albino rats were randomly assigned into four equal groups. The adhesion model was created on the caecum anterior wall and covered with 2 ml 0.9% NaCl, 3% glycerol, 3% sodium pentaborate, and 3% glycerol plus 3% sodium pentaborate solutions in the groups, respectively. Two weeks later, the rats were sacrificed. PPA were graded macroscopically and microscopically. Results. Total adhesion scores of the 3% glycerol + 3% sodium pentaborate group were statistically different from the other groups for macroscopic and also microscopic evaluations (p<0.001). Conclusion. 3% glycerol plus 3% sodium pentaborate as a new formulation has preventive effects on PPA with a synergistic mechanism.

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“…Benefiting from the pioneering work of KCI, other companies started to develop their own devices, and commercialized these at a lower cost compared to the V.A.C. device (Otterbourg, 2012;Garwood and Steinberg, 2016). Currently, fourteen different manufacturers have commercialized NPWT devices, each providing different types of devices (Glass and Nanchahal, 2012;Dumville et al, 2015).…”

Section: Human Medicinementioning

confidence: 99%

Negatieve druktherapie: het verleden en de toekomst

Go¹,

Or²,

Goethem³

et al. 2017

Vlaams Diergeneeskundig Tijdschrift

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Negative pressure wound therapy (NPWT) involves the application of negative pressure on a wound bed for its positive effects on wound healing. Indications for NPWT concern various types of wounds, skin grafts and flaps, partial-thickness burns, open abdomen management and closed incisions. Negative pressure wound therapy has been used for centuries in human medicine. Its first use dates back to the Roman era (around 27 BCE) when human generated pressures were used. Later, European and Russian physicians developed various advanced methods and systems to apply negative pressure on wounds or other injuries. The on-going positive findings in human medicine triggered researchers in veterinary medicine to apply this technique on animal patients. However, much still has to be investigated regarding NPWT, especially in veterinary medicine, as there are many factors playing a role in the mechanisms of this treatment. New methods and techniques are continuously being developed and the existing studies show great potential for NPWT.

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What's new in wound treatment: a critical appraisal

Cited by 32 publications

References 53 publications

Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions

Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions

Effects of Glycerol and Sodium Pentaborate Formulation on Prevention of Postoperative Peritoneal Adhesion Formation

Negatieve druktherapie: het verleden en de toekomst

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