What’s New, What’s Hot in Solid Organ Transplantation? Summary of the American Transplant Congress 2011

Abstract

Breakthroughs in basic and clinical science in solid organ transplantation were presented at the American Transplant Congress 2011. Key areas of presentation included the pathogenesis of late allograft failure, immune regulation and tolerance, pathways in allograft injury, electing appropriate patients for transplantation, determining the best allocation schemes to maximize effective utilization, organ preservation, monitoring the alloimmune response and immunosuppressive management. In this review, we present highlights of the meeting. These presentations demonstrate the exciting promise in translating from the bench to affect patient care.

Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection

“…They found that although treatment with either IL-2C or G-CSF led to a significant delay of MHC-II disparate allogeneic donor skin rejection, the combinatorial treatment was superior to either alone, confirming that MDSCs and Treg prolonged skin allograft survival in mice. Karp and Mannon [51] summarized identified an HLA-Dq α -class-II-derived peptide that was a potent inducer of CD11b+CD115+Gr1+ MDSCs. Moreover, this peptide prolonged the survival of fully mismatched mouse cardiac allografts associated with the induction of Foxp3+ Treg.…”